专利检索 ap:("Vertex Pharmaceuticals Incorporated") AND inv:"Ales MEDEK" 第 1 页

1.

发明申请
SOLID FORMS OF APOL1 INHIBITORS AND METHODS OF USING SAME 有权

公开(公告)号：US20230119114A1

公开(公告)日：2023-04-20

申请号：US17895582

申请日：2022-08-25

申请人： Vertex Pharmaceuticals Incorporated

发明人： Kevin Brett DANIEL , Lori Ann FERRIS , Kevin James GAGNON , Michael David JUDELSON , Mei-Hsiu LAI , Courtney K. MAGUIRE , Ales MEDEK , Andrey PERESYPKIN , Peter Jamison ROSE , Yi SHI , Charlene TSAY

IPC分类号： C07D495/20 , B01J23/46

摘要： The disclosure provides novel solid state forms of Compound I chosen from Compound I Phosphate Salt Hydrate Form A, Compound I free form Monohydrate, Compound I Phosphate Salt Methanol Solvate, and Compound I Phosphate Salt MEK Solvate, compositions comprising the same, and methods of making and using the same, including uses in treating APOL1 mediated disease (such as, e.g., APOL1 mediated kidney disease). Also provided herein are novel solid state forms of Compound II chosen from Compound II Phosphate Salt Hemihydrate Form A, Compound II free form Hemihydrate Form A, and Compound II free form Form C, compositions comprising the same, and methods of making and using the same, including uses in treating APOL1 mediated disease (such as, e.g., APOL1 mediated kidney disease).

2.

发明公开
MODULATORS OF ALPHA-1 ANTITRYPSIN 审中-公开

公开(公告)号：US20240336614A1

公开(公告)日：2024-10-10

申请号：US18487690

申请日：2023-10-16

申请人： Vertex Pharmaceuticals Incorporated

发明人： Upul Keerthi BANDARAGE , Cavan McKeon BLIGH , Diane BOUCHER , Michael John BOYD , Michael Aaron BRODNEY , Michael Philip CLARK , Veronique DAMAGNEZ , Lev Tyler Dewey FANNING , Robert Francis FIMOGNARI , Gabrielle Simone FLEMING , Kevin James GAGNON , Pedro Manuel GARCIA BARRANTES , Robert Daniel GIACOMETTI , Simon GIROUX , Ronald Lee GREY, JR. , Samantha GUIDO , Amy Beth HALL , Sarah Carol HOOD , Dennis James HURLEY , Mac Arthur JOHNSON, JR. , Peter Jones , Sarathy KESAVAN , Mei-Hsiu LAI , Siying LIU , Adam LOOKER , Brad MAXWELL , John Patrick MAXWELL , Ales MEDEK , Philippe Marcel NUHANT , Kirk Alan OVERHOFF , Setu RODAY , Stefanie ROEPER , Steven M. RONKIN , Rupa SAWANT , Yi SHI , Muna SHRESTHA , Marisa SPOSATO , Kathy STAVROPOULOS , Rebecca Jane SWETT , Timothy Lewis TAPLEY , Qing TANG , Stephen THOMSON , Jinwang XU , Mariam ZAKY , Kevin Michael COTTRELL

IPC分类号： C07D487/04 , A61K9/16 , A61K31/4162 , C07D491/18 , C07D513/04 , C07D519/00 , C07F9/6561 , C07H15/26

CPC分类号： C07D487/04 , A61K9/1635 , A61K9/1652 , A61K31/4162 , C07D491/18 , C07D513/04 , C07D519/00 , C07F9/6561 , C07H15/26 , C07B2200/13

摘要： The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I):

tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

3.

发明公开
SOLID FORMS OF APOL1 INHIBITOR AND METHODS OF USING SAME 审中-公开

公开(公告)号：US20230250087A1

公开(公告)日：2023-08-10

申请号：US18001371

申请日：2021-06-11

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Kevin James GAGNON , Jicong LI , Ales MEDEK , Jack Raphael MINCHOM , Yi SHI , Muna SHRESTHA , Faith WITKOS

IPC分类号： C07D403/12

CPC分类号： C07D403/12 , C07B2200/13

摘要： The disclosure provides novel solid state forms of Compound I selected from ethanol solvate Form A, ethanol solvate Form B, citric acid cocrystal Form A, and Form B, compositions comprising the same, and methods of making and using the same, including use in treating APOL1 mediated kidney disease. (I).

4.

发明申请
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 有权

公开(公告)号：US20210032255A1

公开(公告)日：2021-02-04

申请号：US16994968

申请日：2020-08-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jean-Damien CHARRIER , Christopher John DAVIS , Damien FRAYSSE , Gorka ETXEBARRIA I JARDI , Simon PEGG , Francoise PIERARD , Joanne PINDER , John STUDLEY , Carl ZWICKER , Tapan SANGHVI , Michael WALDO , Ales MEDEK , David Matthew SHAW , Maninder PANESAR , Yuegang ZHANG , Naziha ALEM

IPC分类号： C07D487/04 , C07B59/00 , A61K31/519 , C07C45/00 , C07C45/63

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.
The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

5.

发明公开
SOLID FORMS OF 4-(5-(4-FLUOROPHENYL)-6-(TETRAHYDRO-2H-PYRAN-4-YL)-1,5-DIHYDROPYRROLO[2,3-F]INDAZOL-7-YL)BENZOIC ACID 审中-公开

公开(公告)号：US20240002386A1

公开(公告)日：2024-01-04

申请号：US18037121

申请日：2021-11-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： Yi SHI , Mei-Hsiu LAI , Ales MEDEK , Kan-Nian HU , Zhengtian SONG , Elisa A. TORRICO GUZMAN , Kathleen Paige SOKOLOWSKY , Simon GIROUX , Siying LIU , Kirk Alan OVERHOFF , Setu RODAY , Rupa SAWANT , Marisa SPOSATO

IPC分类号： C07D487/04 , C07D471/14

CPC分类号： C07D487/04 , C07D471/14 , C07B2200/13

摘要： Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and methods of using and preparing the same for treatment of alpha-1 antitrypsin deficiency (AATD).

6.

发明公开
INHIBITORS OF APOL1 AND METHODS OF USING SAME 审中-公开

公开(公告)号：US20230203000A1

公开(公告)日：2023-06-29

申请号：US18071153

申请日：2022-11-29

申请人： Vertex Pharmaceuticals Incorporated

发明人： Leslie A. DAKIN , Michael A. BRODNEY , Kevin B. DANIEL , Elena DOLGIKH , Pedro M. GARCIA BARRANTES , Ales MEDEK , Jessica H. OLSEN , Timothy J. SENTER , Akira J. SHIMIZU , Steven D. STONE , Charlene TSAY

IPC分类号： C07D401/04 , C07D401/14 , C07D405/14

CPC分类号： C07D401/04 , C07D401/14 , C07D405/14

摘要： The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

7.

发明公开
INHIBITORS OF APOL1 AND METHODS OF USING SAME 审中-公开

公开(公告)号：US20230271945A1

公开(公告)日：2023-08-31

申请号：US18106569

申请日：2023-02-07

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jingrong CAO , Jon H. COME , Leslie A. DAKIN , Francois DENIS , Warren A. DORSCH , Anne FORTIER , Martine HAMEL , Elaine B. KRUEGER , Brian LEDFORD , Suganthini S. NANTHAKUMAR , Olivier NICOLAS , Camil SAYEGH , Timothy J. SENTER , Tiansheng WANG , Michael BRODNEY , Kan-Nian HU , Peter ROSE , Kevin GAGNON , Yi SHI , Muna SHRESTHA , Ales MEDEK , Faith WITKOS

IPC分类号： C07D403/12 , C07D405/14

CPC分类号： C07D403/12 , C07D405/14 , C07B2200/05 , C07B2200/13

摘要： The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).

8.

发明公开
MODULATORS OF ALPHA-1 ANTITRYPSIN 审中-公开

公开(公告)号：US20230265080A1

公开(公告)日：2023-08-24

申请号：US18107786

申请日：2023-02-09

申请人： Vertex Pharmaceuticals Incorporated

发明人： Upul Keerthi BANDARAGE , Cavan McKeon BLIGH , Michael John BOYD , Diane M. BOUCHER , Michael Aaron BRODNEY , Veronique DAMAGNEZ , Lev Tyler DEWEY FANNING , Mary Elizabeth ECCLES , Robert Francis FIMOGNARI, JR. , Kevin James GAGNON , Pedro M. GARCIA BARRANTES , Simon GIROUX , Ronald Lee GREY, JR. , Amy Beth HALL , Sarah Carol HOOD , Dennis James HURLEY , Joshua Kennedy HUSSEY , Mac Arthur JOHNSON, JR. , Peter JONES , Sarathy KESAVAN , Adam LOOKER , Brad D. MAXWELL , John Patrick MAXWELL , Ales MEDEK , Mettachit NAVAMAL , Philippe Marcel NUHANT , Setu RODAY , Stefanie ROEPER , Rupa SAWANT , Yi SHI , Rebecca Jane SWETT , Qing TANG , Timothy Lewis TAPLEY , Stephen A. THOMSON , Michael WALDO , Jinwang XU , Kevin Michael COTTRELL

IPC分类号： C07D403/04 , C07D519/00

CPC分类号： C07D403/04 , C07D519/00 , C07B2200/05 , C07B2200/13

摘要： Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

9.

发明申请
SOLID FORMS OF APOL1 INHIBITOR AND METHODS OF USING SAME 有权

公开(公告)号：US20210246121A1

公开(公告)日：2021-08-12

申请号：US17166927

申请日：2021-02-03

申请人： Vertex Pharmaceuticals Incorporated

发明人： Mei-Hsiu LAI , Jicong LI , Muna SHRESTHA , Ales MEDEK , Yi SHI , Andrey PERESYPKIN , Michael JUDELSON , Jack MINCHOM , Courtney MAGUIRE , Kevin GAGNON , Faith WITKOS , Satish Kumar IYEMPERUMAL , Kanika SARPAL

IPC分类号： C07D403/12

摘要： The disclosure provides novel solid state forms of Compound I selected from Form B, citric acid cocrystal Form A, piperazine cocrystal Form A, urea cocrystal Form A, nicotinamide cocrystal Form A, nicotinamide cocrystal Form B, aspartame cocrystal Form A, glutaric acid cocrystal Form A, L-proline cocrystal Form A, L-proline cocrystal Form B, vanillin cocrystal Form A, and 2-pyridone cocrystal Form A, compositions comprising the same, and methods of using the same, including use in treating APOL1 mediated kidney disease.