公开(公告)号：US20210032255A1

公开(公告)日：2021-02-04

申请号：US16994968

申请日：2020-08-17

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Jean-Damien CHARRIER ,  Christopher John DAVIS ,  Damien FRAYSSE ,  Gorka ETXEBARRIA I JARDI ,  Simon PEGG ,  Francoise PIERARD ,  Joanne PINDER ,  John STUDLEY ,  Carl ZWICKER ,  Tapan SANGHVI ,  Michael WALDO ,  Ales MEDEK ,  David Matthew SHAW ,  Maninder PANESAR ,  Yuegang ZHANG ,  Naziha ALEM

IPC: C07D487/04 ,  C07B59/00 ,  A61K31/519 ,  C07C45/00 ,  C07C45/63

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.
The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

公开(公告)号：US20230265080A1

公开(公告)日：2023-08-24

申请号：US18107786

申请日：2023-02-09

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Upul Keerthi BANDARAGE ,  Cavan McKeon BLIGH ,  Michael John BOYD ,  Diane M. BOUCHER ,  Michael Aaron BRODNEY ,  Veronique DAMAGNEZ ,  Lev Tyler DEWEY FANNING ,  Mary Elizabeth ECCLES ,  Robert Francis FIMOGNARI, JR. ,  Kevin James GAGNON ,  Pedro M. GARCIA BARRANTES ,  Simon GIROUX ,  Ronald Lee GREY, JR. ,  Amy Beth HALL ,  Sarah Carol HOOD ,  Dennis James HURLEY ,  Joshua Kennedy HUSSEY ,  Mac Arthur JOHNSON, JR. ,  Peter JONES ,  Sarathy KESAVAN ,  Adam LOOKER ,  Brad D. MAXWELL ,  John Patrick MAXWELL ,  Ales MEDEK ,  Mettachit NAVAMAL ,  Philippe Marcel NUHANT ,  Setu RODAY ,  Stefanie ROEPER ,  Rupa SAWANT ,  Yi SHI ,  Rebecca Jane SWETT ,  Qing TANG ,  Timothy Lewis TAPLEY ,  Stephen A. THOMSON ,  Michael WALDO ,  Jinwang XU ,  Kevin Michael COTTRELL

IPC: C07D403/04 ,  C07D519/00

CPC classification number: C07D403/04 ,  C07D519/00 ,  C07B2200/05 ,  C07B2200/13

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

公开(公告)号：US20210179587A1

公开(公告)日：2021-06-17

申请号：US16593118

申请日：2019-10-04

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Upul Keerthi BANDARAGE ,  Cavan McKeon BLIGH ,  Michael John BOYD ,  Diane M. BOUCHER ,  Michael Aaron BRODNEY ,  Veronique DAMAGNEZ ,  Lev Tyler DEWEY FANNING ,  Mary Elizabeth ECCLES ,  Robert Francis FIMOGNARI, JR. ,  Kevin James GAGNON ,  Pedro M. GARCIA BARRANTES ,  Simon GIROUX ,  Ronald Lee GREY, JR. ,  Amy Beth HALL ,  Sarah Carol HOOD ,  Dennis James HURLEY ,  Joshua Kennedy HUSSEY ,  Mac Arthur JOHNSON, JR. ,  Peter JONES ,  Sarathy KESAVAN ,  Adam LOOKER ,  Brad D. MAXWELL ,  John Patrick MAXWELL ,  Ales MEDEK ,  Mettachit NAVAMAL ,  Philippe Marcel NUHANT ,  Setu RODAY ,  Stefanie ROEPER ,  Rupa SAWANT ,  Yi SHI ,  Rebecca Jane SWETT ,  Qing TANG ,  Timothy Lewis TAPLEY ,  Stephen A. THOMSON ,  Michael WALDO ,  Jinwang XU

IPC: C07D403/04 ,  C07D519/00

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).