公开(公告)号：US20190047995A1

公开(公告)日：2019-02-14

申请号：US15967110

申请日：2018-04-30

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jean-Damien CHARRIER ,  Steven John DURRANT ,  David KAY ,  Ronald Marcellus Alphonsus KNEGTEL ,  Somhairle MACCORMICK ,  Michael Paul MORTIMORE ,  Michael Edward O'DONNELL ,  Joanne PINDER ,  Alistair RUTHERFORD ,  Anisa Nizarali VIRANI ,  Stephen Clinton YOUNG ,  Philip Michael REAPER

IPC分类号： C07D413/14 ,  A61P35/00 ,  C07D401/04 ,  C07D417/14 ,  C07D471/04 ,  C07D417/12 ,  C07D417/04 ,  C07D413/12 ,  C07D413/04 ,  C07D409/14 ,  C07D403/12 ,  C07D401/14 ,  C07D409/04 ,  C07D405/12 ,  C07D405/04 ,  C07D403/10 ,  C07D241/28 ,  C07D401/10 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14

摘要： The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

公开(公告)号：US20210047333A1

公开(公告)日：2021-02-18

申请号：US17007412

申请日：2020-08-31

申请人： Vertex Pharmaceuticals Incorporated

发明人： Nadia AHMAD ,  Dean BOYALL ,  Jean-Damien CHARRIER ,  Chris DAVIS ,  Rebecca DAVIS ,  Steven DURRANT ,  Gorka ETXEBARRIA I JARDI ,  Damien FRAYSSE ,  Juan-Miguel JIMENEZ ,  David KAY ,  Ronald KNEGTEL ,  Donald MIDDLETON ,  Michael O'DONNELL ,  Maninder PANESAR ,  Francoise PIERARD, Marie ,  Joanne PINDER ,  David SHAW ,  Pierre-Henri STORCK ,  John STUDLEY ,  Heather TWIN

IPC分类号： C07D487/04 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/10

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein.
Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

公开(公告)号：US20230271963A1

公开(公告)日：2023-08-31

申请号：US17847938

申请日：2022-06-23

申请人： Vertex Pharmaceuticals Incorporated

发明人： Nadia AHMAD ,  Dean BOYALL ,  Jean-Damien CHARRIER ,  Chris DAVIS ,  Rebecca DAVIS ,  Steven DURRANT ,  Gorka ETXEBARRIA I JARDI ,  Damien FRAYSSE ,  Juan-Miguel JIMENEZ ,  David KAY ,  Ronald KNEGTEL ,  Donald MIDDLETON ,  Michael O'DONNELL ,  Maninder PANESAR ,  Francoise PIERARD ,  Joanne PINDER ,  David SHAW ,  Pierre-Henri STORCK ,  John STUDLEY ,  Heather TWIN

IPC分类号： C07D487/04 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/10

CPC分类号： C07D487/04 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/10

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I:




or a pharmaceutically acceptable salt, wherein the variables are as devined herein.
Moreover, The compounds of this invention have formula I-A:




or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

公开(公告)号：US20210032255A1

公开(公告)日：2021-02-04

申请号：US16994968

申请日：2020-08-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jean-Damien CHARRIER ,  Christopher John DAVIS ,  Damien FRAYSSE ,  Gorka ETXEBARRIA I JARDI ,  Simon PEGG ,  Francoise PIERARD ,  Joanne PINDER ,  John STUDLEY ,  Carl ZWICKER ,  Tapan SANGHVI ,  Michael WALDO ,  Ales MEDEK ,  David Matthew SHAW ,  Maninder PANESAR ,  Yuegang ZHANG ,  Naziha ALEM

IPC分类号： C07D487/04 ,  C07B59/00 ,  A61K31/519 ,  C07C45/00 ,  C07C45/63

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.
The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.