公开(公告)号：US20230203000A1

公开(公告)日：2023-06-29

申请号：US18071153

申请日：2022-11-29

申请人： Vertex Pharmaceuticals Incorporated

发明人： Leslie A. DAKIN ,  Michael A. BRODNEY ,  Kevin B. DANIEL ,  Elena DOLGIKH ,  Pedro M. GARCIA BARRANTES ,  Ales MEDEK ,  Jessica H. OLSEN ,  Timothy J. SENTER ,  Akira J. SHIMIZU ,  Steven D. STONE ,  Charlene TSAY

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14

摘要： The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).