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公开(公告)号：US20170343477A1
公开(公告)日：2017-11-30
申请号：US15607457
申请日：2017-05-27
发明人： Charles Santori , Supriyo Sinha , Cheng-Hsun Wu , James Higbie , Seung Ah Lee
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0075 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/18 , G01J3/2823 , G01J3/32 , G01J3/433 , G01J3/4406 , G01J2003/1243 , G01N21/6408 , G01N21/6445 , G01N21/6458 , G01N2021/6471 , G01N2201/0675 , G02B21/004 , G02B21/0076 , G02B21/16
摘要： Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths, and a first set of optical elements that include a first spatial light modulator (SLM), at least one lens, and at least one dispersive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction.
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公开(公告)号：US20240065548A1
公开(公告)日：2024-02-29
申请号：US18504961
申请日：2023-11-08
发明人： Ryan Kramer , Sam Kavusi , Eliezer Glik , Seung Ah Lee , Chinmay Belthangady
CPC分类号： A61B3/152 , A61B3/0041 , A61B3/0091 , A61B3/032 , A61B3/112 , A61B3/113 , A61B3/1225 , A61B3/145 , A61B3/0008
摘要： The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.
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公开(公告)号：US10591417B2
公开(公告)日：2020-03-17
申请号：US16448670
申请日：2019-06-21
发明人： Charles Santori , Supriyo Sinha , Cheng-Hsun Wu , James Higbie , Seung Ah Lee
IPC分类号： G01J3/18 , G01N21/64 , G01J3/44 , G02B21/00 , G02B21/16 , G01J3/10 , G01J3/28 , G01J3/433 , G01J3/02 , A61B5/00 , G01J3/32 , G01J3/12
摘要： Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths and a diffractive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction.
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公开(公告)号：US11844573B2
公开(公告)日：2023-12-19
申请号：US17321672
申请日：2021-05-17
发明人： Ryan Kramer , Sam Kavusi , Eliezer Glik , Seung Ah Lee , Chinmay Belthangady
CPC分类号： A61B3/152 , A61B3/0041 , A61B3/0091 , A61B3/032 , A61B3/112 , A61B3/113 , A61B3/1225 , A61B3/145 , A61B3/0008
摘要： The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.
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公开(公告)号：US11737673B1
公开(公告)日：2023-08-29
申请号：US17376612
申请日：2021-07-15
发明人： Chinmay Belthangady , Tamara Troy , Supriyo Sinha , Daniele Piponi , Eden Rephaeli , Seung Ah Lee , Maximilian Kapczynski
IPC分类号： A61B5/00
CPC分类号： A61B5/0088 , A61B5/0086 , A61B2562/146 , A61B2576/02
摘要： Systems, apparatuses, and methods for detecting carious lesions are described herein. In an example, the systems in an optical interrogator including a single-pixel photodetector responsive to short-wave infrared light and operatively coupled to a controller. In an example the optical interrogator includes a light engine for emitting light, a scanning mirror assembly and a single-pixel photodetector. In an example, the methods include causing the light engine to emit light having wavelengths in a range of about 900 nm to about 1,700 nm; selectively directing the light over different portions of a tooth with a scanning mirror assembly to provide scattered light; and correlating scattered light signals generated by the single-pixel photodetector in response to the scattered light with the portion of the tooth.
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公开(公告)号：US11514270B2
公开(公告)日：2022-11-29
申请号：US16939301
申请日：2020-07-27
摘要： Embodiments may include a method to estimate motion data based on test image data sets. The method may include receiving a training data set comprising a plurality of training data elements. Each element may include an image data set and a motion data set. The method may include training a machine learning model using the training data set, resulting in identifying one or more parameters of a function in the machine learning model based on correspondences between the image data sets and the motion data sets. The method may further include receiving a test image data set. The test image data set may include intensities of pixels in a deep-tissue image. The method may include using the trained machine learning model and the test image data set to generate output data for the test image data set. The output data may characterize motion represented in the test image data set.
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公开(公告)号：US20210338079A1
公开(公告)日：2021-11-04
申请号：US17321672
申请日：2021-05-17
发明人： Ryan Kramer , Sam Kavusi , Eliezer Glik , Seung Ah Lee , Chinmay Belthangady
摘要： The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.
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公开(公告)号：US10776667B2
公开(公告)日：2020-09-15
申请号：US16101653
申请日：2018-08-13
摘要： Embodiments may include a method to estimate motion data based on test image data sets. The method may include receiving a training data set comprising a plurality of training data elements. Each element may include an image data set and a motion data set. The method may include training a machine learning model using the training data set, resulting in identifying one or more parameters of a function in the machine learning model based on correspondences between the image data sets and the motion data sets. The method may further include receiving a test image data set. The test image data set may include intensities of pixels in a deep-tissue image. The method may include using the trained machine learning model and the test image data set to generate output data for the test image data set. The output data may characterize motion represented in the test image data set.
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公开(公告)号：US20200182793A1
公开(公告)日：2020-06-11
申请号：US16788730
申请日：2020-02-12
发明人： Cheng-Hsun Wu , Brian M. Rabkin , Supriyo Sinha , John D. Perreault , Chinmay Belthangady , James Higbie , Seung Ah Lee
摘要： The present disclosure relates to systems and methods for cellular imaging and identification through the use of a light sheet flow cytometer. In one implementation, a light sheet flow cytometer may include a light source configured to emit light having one or more wavelengths, at least one optical element configured to form a light sheet from the emitted light, a microfluidic channel configured to hold a sample, and an imaging device. The imaging device may be adapted to forming 3-D images of the sample such that identification tags attached to the sample are visible.
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公开(公告)号：US10605733B1
公开(公告)日：2020-03-31
申请号：US15833677
申请日：2017-12-06
发明人： Cheng-Hsun Wu , Brian M. Rabkin , Supriyo Sinha , John D. Perreault , Chinmay Belthangady , James Higbie , Seung Ah Lee
摘要： The present disclosure relates to systems and methods for cellular imaging and identification through the use of a light sheet flow cytometer. In one implementation, a light sheet flow cytometer may include a light source configured to emit light having one or more wavelengths, at least one optical element configured to form a light sheet from the emitted light, a microfluidic channel configured to hold a sample, and an imaging device. The imaging device may be adapted to forming 3-D images of the sample such that identification tags attached to the sample are visible.
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