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公开(公告)号：US20160264598A1
公开(公告)日：2016-09-15
申请号：US15162395
申请日：2016-05-23
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Randy W. JACKSON , Jodie HAMRICK , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K31/198 , A61K31/69 , A61K45/06 , A61K2300/00
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20150361108A1
公开(公告)日：2015-12-17
申请号：US14737156
申请日：2015-06-11
发明人： Christopher J. BURNS , Denis DAIGLE , Jodie HAMRICK , Bin LIU , Randy W. JACKSON , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K31/427 , A61K31/43 , A61K31/69 , A61K45/06 , Y02A50/473 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases and methods thereof. In some embodiments, the compounds described herein are biologically hydrolyzed to a beta-lactamase inhibitor. In certain embodiments, the compounds described herein are useful for the treatment of bacterial infections.
摘要翻译： 本文描述了调节β-内酰胺酶活性的化合物和组合物及其方法。 在一些实施方案中，本文所述的化合物生物水解成β-内酰胺酶抑制剂。 在某些实施方案中，本文所述的化合物可用于治疗细菌感染。
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公开(公告)号：US20220125812A1
公开(公告)日：2022-04-28
申请号：US17296371
申请日：2019-11-22
发明人： Christopher J. BURNS , Denis DAIGLE , Jodie HAMRICK , Daniel C. PEVEAR , Robert E. Lee TROUT , Luigi XERRI , Timothy HENKEL , Cullen L. MYERS , Stephen M. CONDON , Anthony DRAGER , Lawrence ROSEN
IPC分类号： A61K31/69 , A61K31/545
摘要： The present invention relates to pharmaceutical compositions containing boron-containing compounds and their use as inhibitors of beta-lactamase enzymes and as antibacterial agents in combination with a beta-lactam antibiotic.
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公开(公告)号：US20180291039A1
公开(公告)日：2018-10-11
申请号：US16002363
申请日：2018-06-07
发明人： Christopher J. BURNS , Daniel C. PEVEAR , Robert E. Lee TROUT , Randy W. Jackson , Jodie HAMRICK , Allison L. ZULLI , Eugen F. MESAROS , Steven A. BOYD
CPC分类号： C07F5/025 , A61K31/427 , A61K31/43 , A61K31/545 , A61K31/546 , A61K31/69 , A61K45/06 , A61K2300/00 , A61P31/04
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20170145037A1
公开(公告)日：2017-05-25
申请号：US15366769
申请日：2016-12-01
发明人： Christopher J. BURNS , Denis DAIGLE , Jodie HAMRICK , Bin LIU , Randy W. JACKSON , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K31/427 , A61K31/43 , A61K31/69 , A61K45/06 , Y02A50/473 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases and methods thereof. In some embodiments, the compounds described herein are biologically hydrolyzed to a beta-lactamase inhibitor. In certain embodiments, the compounds described herein are useful for the treatment of bacterial infections.
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公开(公告)号：US20210198288A1
公开(公告)日：2021-07-01
申请号：US17057593
申请日：2019-05-23
发明人： Christopher J. BURNS , Denis DAIGLE , Guo-Hua CHU , Jodie HAMRICK , Steven A. BOYD , Allison L. ZULLI , Eugen F. MESAROS , Stephen M. CONDON , Robert E. Lee TROUT , Cullen L. MYERS , Zhenrong XU
摘要： Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20170226135A1
公开(公告)日：2017-08-10
申请号：US15435097
申请日：2017-02-16
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Randy W. JACKSON , Jodie HAMRICK , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K31/198 , A61K31/69 , A61K45/06 , A61K2300/00
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20230114728A1
公开(公告)日：2023-04-13
申请号：US17779804
申请日：2020-09-24
发明人： Christopher J. BURNS , Denis DAIGLE , Guo-Hua CHU , Jodie HAMRICK , Steven A. BOYD , Allison L. ZULLI , Stephen M. CONDON , Cullen L. MYERS , Zhenrong XU , Tsuyoshi Uehara , Nathan LINE
摘要： Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20210188851A1
公开(公告)日：2021-06-24
申请号：US17057594
申请日：2019-05-29
IPC分类号： C07D477/20 , A61K45/06 , A61K31/407 , A61P31/04
摘要： The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.
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公开(公告)号：US20170342092A1
公开(公告)日：2017-11-30
申请号：US15675253
申请日：2017-08-11
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Randy W. JACKSON , Jodie HAMRICK , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K31/198 , A61K31/69 , A61K45/06 , A61K2300/00
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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