公开(公告)号：US20210198288A1

公开(公告)日：2021-07-01

申请号：US17057593

申请日：2019-05-23

申请人： VenatoRx Pharmaceuticals, Inc.

发明人： Christopher J. BURNS ,  Denis DAIGLE ,  Guo-Hua CHU ,  Jodie HAMRICK ,  Steven A. BOYD ,  Allison L. ZULLI ,  Eugen F. MESAROS ,  Stephen M. CONDON ,  Robert E. Lee TROUT ,  Cullen L. MYERS ,  Zhenrong XU

IPC分类号： C07F5/02 ,  A61P31/04

摘要： Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US20180291039A1

公开(公告)日：2018-10-11

申请号：US16002363

申请日：2018-06-07

申请人： VenatoRx Pharmaceuticals, Inc.

发明人： Christopher J. BURNS ,  Daniel C. PEVEAR ,  Robert E. Lee TROUT ,  Randy W. Jackson ,  Jodie HAMRICK ,  Allison L. ZULLI ,  Eugen F. MESAROS ,  Steven A. BOYD

IPC分类号： C07F5/02 ,  A61K31/69 ,  A61P31/04

CPC分类号： C07F5/025 ,  A61K31/427 ,  A61K31/43 ,  A61K31/545 ,  A61K31/546 ,  A61K31/69 ,  A61K45/06 ,  A61K2300/00 ,  A61P31/04

摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US20240270762A1

公开(公告)日：2024-08-15

申请号：US18563292

申请日：2022-03-25

申请人： Venatorx Pharmaceuticals, Inc.

发明人： Christopher J. BURNS ,  Denis DAIGLE ,  Guo-Hua CHU ,  Jodie HAMRICK ,  Steven A. BOYD ,  Allison L. ZULLI ,  Stephen M. CONDON ,  Cullen L. MYERS ,  Zhenrong XU ,  Tsuyoshi UEHARA ,  Nathan LINE

IPC分类号： C07F5/02 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K31/69 ,  A61P31/04 ,  C07F9/6596

CPC分类号： C07F5/025 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4825 ,  A61K9/4858 ,  A61K31/69 ,  A61P31/04 ,  C07F9/6596

摘要： Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US20200157123A1

公开(公告)日：2020-05-21

申请号：US16616294

申请日：2018-05-25

申请人： VenatoRx Pharmaceuticals, Inc.

发明人： Christopher J. BURNS ,  Denis DAIGLE ,  Guo-Hua CHU ,  Jodie HAMRICK ,  Matthew LUCAS ,  Steven A. Boyd ,  Allison L. ZULLI ,  Eugen F. MESAROS ,  Stephen M. CONDON ,  Robert E. Lee TROUT ,  Cullen L. MYERS

IPC分类号： C07F5/02 ,  A61K9/20 ,  A61P31/04 ,  A61K9/48

摘要： Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US20230114728A1

公开(公告)日：2023-04-13

申请号：US17779804

申请日：2020-09-24

申请人： Venatorx Pharmaceuticals, Inc.

发明人： Christopher J. BURNS ,  Denis DAIGLE ,  Guo-Hua CHU ,  Jodie HAMRICK ,  Steven A. BOYD ,  Allison L. ZULLI ,  Stephen M. CONDON ,  Cullen L. MYERS ,  Zhenrong XU ,  Tsuyoshi Uehara ,  Nathan LINE

IPC分类号： C07F5/02 ,  A61P31/04 ,  A61K47/20

摘要： Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US20220194964A1

公开(公告)日：2022-06-23

申请号：US17599913

申请日：2020-04-01

申请人： Venatorx Pharmaceuticals, Inc.

发明人： Christopher J. BURNS ,  Lawrence ROSEN ,  Stephen M. CONDON ,  Eugen F. MESAROS ,  Allison L. ZULLI ,  Robert E. Lee TROUT ,  Yijun DENG ,  Steven A. BOYD ,  Robert SIMPSON

IPC分类号： C07F5/02 ,  A61K31/545 ,  A61K45/06

摘要： Disclosed herein are crystalline forms of ((2-Ethylbutanoyl)oxy)methyl (R)-2-hydroxy-3-propionamido-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylate. Also disclosed herein are methods of treating a bacterial with a crystalline form of ((2-Ethylbutanoyl)oxy)methyl (R)-2-hydroxy-3-propionamido-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylate.