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公开(公告)号：US20240018166A1
公开(公告)日：2024-01-18
申请号：US18254031
申请日：2021-11-23
发明人： Bin LIU , Jiangchao YAO , Thomas HAIMOWITZ , Christopher BENETATOS , Stephen M. CONDON , Steven A. BOYD
摘要： Disclosed herein are NLRP3 inflammasome inhibitors and compositions thereof. Also disclosed herein are methods including administering a therapeutically effective amount of a composition comprising at least one NLRP3 inflammasome inhibitor to a subject in need thereof.
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公开(公告)号：US11560392B2
公开(公告)日：2023-01-24
申请号：US17115514
申请日：2020-12-08
发明人： Franz Amann , Matthew M. Bio , Jonas Bürgler , Yuanqing Fang , David Ford , Daniel McGarry
IPC分类号： C07F5/02
摘要： Described herein are boron-containing compounds, compositions, and methods for their preparation.
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公开(公告)号：US20220125812A1
公开(公告)日：2022-04-28
申请号：US17296371
申请日：2019-11-22
发明人： Christopher J. BURNS , Denis DAIGLE , Jodie HAMRICK , Daniel C. PEVEAR , Robert E. Lee TROUT , Luigi XERRI , Timothy HENKEL , Cullen L. MYERS , Stephen M. CONDON , Anthony DRAGER , Lawrence ROSEN
IPC分类号： A61K31/69 , A61K31/545
摘要： The present invention relates to pharmaceutical compositions containing boron-containing compounds and their use as inhibitors of beta-lactamase enzymes and as antibacterial agents in combination with a beta-lactam antibiotic.
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公开(公告)号：US20190225628A1
公开(公告)日：2019-07-25
申请号：US16238363
申请日：2019-01-02
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20180291039A1
公开(公告)日：2018-10-11
申请号：US16002363
申请日：2018-06-07
发明人： Christopher J. BURNS , Daniel C. PEVEAR , Robert E. Lee TROUT , Randy W. Jackson , Jodie HAMRICK , Allison L. ZULLI , Eugen F. MESAROS , Steven A. BOYD
CPC分类号： C07F5/025 , A61K31/427 , A61K31/43 , A61K31/545 , A61K31/546 , A61K31/69 , A61K45/06 , A61K2300/00 , A61P31/04
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20170342093A1
公开(公告)日：2017-11-30
申请号：US15675262
申请日：2017-08-11
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT , Randy W. JACKSON
IPC分类号： C07F5/02 , A61K31/546 , A61K31/407 , A61K31/496 , A61K45/06 , A61K31/69
CPC分类号： C07F5/025 , A61K31/407 , A61K31/496 , A61K31/546 , A61K31/69 , A61K45/06 , Y02A50/47 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US09828391B2
公开(公告)日：2017-11-28
申请号：US15212959
申请日：2016-07-18
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout
CPC分类号： C07F5/025 , A61K9/0019 , A61K9/0053 , A61K31/69 , A61K45/06 , C07F5/027 , C07F5/04
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US20170145037A1
公开(公告)日：2017-05-25
申请号：US15366769
申请日：2016-12-01
发明人： Christopher J. BURNS , Denis DAIGLE , Jodie HAMRICK , Bin LIU , Randy W. JACKSON , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT
CPC分类号： C07F5/025 , A61K31/427 , A61K31/43 , A61K31/69 , A61K45/06 , Y02A50/473 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases and methods thereof. In some embodiments, the compounds described herein are biologically hydrolyzed to a beta-lactamase inhibitor. In certain embodiments, the compounds described herein are useful for the treatment of bacterial infections.
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公开(公告)号：US20140194386A1
公开(公告)日：2014-07-10
申请号：US14152916
申请日：2014-01-10
发明人： Christopher J. BURNS , Denis DAIGLE , Bin LIU , Daniel McGARRY , Daniel C. PEVEAR , Robert E. Lee TROUT , Randy W. JACKSON
IPC分类号： C07F5/02
CPC分类号： C07F5/025 , A61K31/407 , A61K31/496 , A61K31/546 , A61K31/69 , A61K45/06 , Y02A50/47 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
摘要翻译： 本文描述了调节β-内酰胺酶活性的化合物和组合物。 在一些实施方案中，本文所述的化合物抑制β-内酰胺酶。 在某些实施方案中，本文所述的化合物可用于治疗细菌感染。
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