公开(公告)号：US12102648B2

公开(公告)日：2024-10-01

申请号：US18159327

申请日：2023-01-25

Applicant: Venatorx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Glen Coburn ,  Guo-Hua Chu ,  Stephen M. Condon ,  Steven A. Boyd ,  Daniel C. Pevear

IPC: A61K31/7076 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K31/53 ,  A61K31/675 ,  A61K31/685 ,  A61K31/7072 ,  C07D487/04 ,  C07F9/6561 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16

CPC classification number: A61K31/7076 ,  A61K9/0053 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K31/53 ,  A61K31/675 ,  A61K31/685 ,  A61K31/7072 ,  C07D487/04 ,  C07F9/6561 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16

Abstract: Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.

公开(公告)号：US11638715B2

公开(公告)日：2023-05-02

申请号：US17842402

申请日：2022-06-16

Applicant: Venatorx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Glen Coburn ,  Guo-Hua Chu ,  Stephen M. Condon ,  Steven A. Boyd ,  Daniel C. Pevear

IPC: A61K31/7076 ,  A61K9/48 ,  C07H19/16 ,  C07H19/06 ,  C07F9/6561 ,  C07H19/10 ,  A61K31/53 ,  A61K31/7072 ,  A61K31/685 ,  A61K31/675 ,  A61K9/00 ,  A61K9/20 ,  C07D487/04

Abstract: Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.

公开(公告)号：US12084445B2

公开(公告)日：2024-09-10

申请号：US17057594

申请日：2019-05-29

Applicant: VenatoRx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Guo-Hua Chu ,  Jodie Hamrick ,  Steven A. Boyd ,  Stephen M. Condon

IPC: A61K31/403 ,  A61K45/06 ,  A61P31/04 ,  C07D477/20 ,  A61K31/407

CPC classification number: C07D477/20 ,  A61K31/403 ,  A61K45/06 ,  A61P31/04 ,  A61K31/407

Abstract: The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.

公开(公告)号：US11566001B2

公开(公告)日：2023-01-31

申请号：US17514578

申请日：2021-10-29

Applicant: Venatorx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Glen Coburn ,  Bin Liu ,  Jiangchao Yao ,  Christopher Benetatos ,  Steven A. Boyd ,  Stephen M. Condon ,  Thomas Haimowitz

IPC: C07D487/04 ,  C07D207/34 ,  A61P31/20 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D403/06 ,  C07D498/04 ,  C07D401/06 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D513/04 ,  C07D207/337 ,  C07D401/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F5/02

Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

公开(公告)号：US11046716B2

公开(公告)日：2021-06-29

申请号：US16514904

申请日：2019-07-17

Applicant: VenatoRx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Bin Liu ,  Jiangchao Yao ,  Denis Daigle ,  Steven A. Boyd

IPC: A61K31/395 ,  C07F5/02 ,  A61K31/69 ,  A61K45/06 ,  A61K31/407 ,  A61K31/546

Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US10590076B2

公开(公告)日：2020-03-17

申请号：US16438361

申请日：2019-06-11

Applicant: VenatoRx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Glen Coburn ,  Bin Liu ,  Jiangchao Yao ,  Christopher Benetatos ,  Steven A. Boyd ,  Stephen M. Condon ,  Thomas Haimowitz

IPC: C07D207/337 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  C07D513/04 ,  C07D207/34 ,  A61P31/20 ,  C07D403/06 ,  C07D498/04 ,  C07D471/04 ,  C07D401/14 ,  C07F5/02

Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

公开(公告)号：US10399996B2

公开(公告)日：2019-09-03

申请号：US15261359

申请日：2016-09-09

Applicant: VenatoRx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Bin Liu ,  Jiangchao Yao ,  Denis Daigle ,  Steven A. Boyd

IPC: C07F5/02 ,  A61K31/69 ,  A61K45/06 ,  A61K31/407 ,  A61K31/546

Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US12173018B2

公开(公告)日：2024-12-24

申请号：US17057593

申请日：2019-05-23

Applicant: VenatoRx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Denis Daigle ,  Guo-Hua Chu ,  Jodie Hamrick ,  Steven A. Boyd ,  Allison L Zulli ,  Eugen F. Mesaros ,  Stephen M. Condon ,  Robert E. Lee Trout ,  Cullen L. Myers ,  Zhenrong Xu

IPC: A61P31/04 ,  C07F5/02

Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US11267826B2

公开(公告)日：2022-03-08

申请号：US16616382

申请日：2018-05-25

Applicant: VenatoRx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Denis Daigle ,  Guo-Hua Chu ,  Randy W. Jackson ,  Jodie Hamrick ,  Matthew Lucas ,  Steven A. Boyd ,  Jiangchao Yao ,  Eugen F. Mesaros

IPC: C07F5/02 ,  A61K45/06

Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US11247965B2

公开(公告)日：2022-02-15

申请号：US16771387

申请日：2018-12-10

Applicant: VenatoRx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Glen Coburn ,  Bin Liu ,  Jiangchao Yao ,  Christopher Benetatos ,  Steven A. Boyd ,  Stephen M. Condon

IPC: C07C233/64 ,  C07D211/46 ,  C07D307/66 ,  C07D265/30 ,  C07D309/14 ,  A61K45/06

Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.