公开(公告)号：US12173018B2

公开(公告)日：2024-12-24

申请号：US17057593

申请日：2019-05-23

Applicant: VenatoRx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Denis Daigle ,  Guo-Hua Chu ,  Jodie Hamrick ,  Steven A. Boyd ,  Allison L Zulli ,  Eugen F. Mesaros ,  Stephen M. Condon ,  Robert E. Lee Trout ,  Cullen L. Myers ,  Zhenrong Xu

IPC: A61P31/04 ,  C07F5/02

Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US11332485B2

公开(公告)日：2022-05-17

申请号：US16616294

申请日：2018-05-25

Applicant: VenatoRx Pharmaceuticals, Inc.

Inventor： Christopher J. Burns ,  Denis Daigle ,  Guo-Hua Chu ,  Jodie Hamrick ,  Matthew Lucas ,  Steven A. Boyd ,  Allison L. Zulli ,  Eugen F. Mesaros ,  Stephen M. Condon ,  Robert E. Lee Trout ,  Cullen L. Myers

IPC: C07F5/02 ,  A61P31/04 ,  A61K9/20 ,  A61K9/48

Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.