公开(公告)号：US20230114728A1

公开(公告)日：2023-04-13

申请号：US17779804

申请日：2020-09-24

Applicant: Venatorx Pharmaceuticals, Inc.

Inventor： Christopher J. BURNS ,  Denis DAIGLE ,  Guo-Hua CHU ,  Jodie HAMRICK ,  Steven A. BOYD ,  Allison L. ZULLI ,  Stephen M. CONDON ,  Cullen L. MYERS ,  Zhenrong XU ,  Tsuyoshi Uehara ,  Nathan LINE

IPC: C07F5/02 ,  A61P31/04 ,  A61K47/20

Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.