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公开(公告)号：US12214083B2
公开(公告)日：2025-02-04
申请号：US18355475
申请日：2023-07-20
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Eleni Dokou , Shahla Jamzad , John P. Caesar, Jr. , Majed Fawaz , Laura Das , Chong-Hui Gu , Patricia Nell Hurter , Meghna Jai Israni , Meghan M. Johnston , Dragutin Knezic , Andrew G. Kuzmission , HongRen Wang
IPC: A61K9/20 , A61K9/14 , A61K9/16 , A61K9/48 , A61K31/47 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , A61P1/10 , A61P1/16 , A61P1/18 , A61P3/00 , C07D215/56
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
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公开(公告)号：US10272046B2
公开(公告)日：2019-04-30
申请号：US15181114
申请日：2016-06-13
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Eleni Dokou , Shahla Jamzad , John P. Caesar, Jr. , Majed Fawaz , Laura Das , Chong-Hui Gu , Patricia Nell Hurter , Meghna Jai Israni , Meghan M. Johnston , Dragutin Knezic , Andrew G. Kuzmission , HongRen Wang
IPC: A61K9/48 , A61K9/20 , A61K38/00 , A61K31/47 , A61K9/16 , C07D215/56 , A61K9/14 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
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公开(公告)号：US20150024047A1
公开(公告)日：2015-01-22
申请号：US14510507
申请日：2014-10-09
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Eleni Dokou , Shahla Jamzad , John P. Caesar, JR. , Majed Fawaz , Laura Das , Chong-Hui Gu , Patricia Nell Hurter , Meghna Jai Israni , Meghan M. Johnston , Dragutin Knezic , Andrew G. Kuzmission , HongRen Wang
IPC: A61K31/47 , A61K47/12 , A61K47/38 , A61K9/16 , A61K47/26 , A61K9/20 , A61K9/14 , A61K47/02 , A61K47/20
CPC classification number: A61K9/205 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/47 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , C07D215/56
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
Abstract translation: 本发明涉及含有N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，其包括 粉末，颗粒和微型片剂的固体分散体，粉末的制造和加工方法，颗粒和微型片剂，以及使用该药物组合物治疗囊性纤维化的方法。
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4.发明授权公开(公告)号：US10231932B2
公开(公告)日：2019-03-19
申请号：US15035969
申请日：2014-10-31
Applicant: VERTEX PHARMACEUTICALS INCORPORATED
Inventor： Kelly Ann Swinney , Patricia Nell Hurter , David E. Nadig , David Smith , Vance Hayden Thomas , Martin Paul Warman
Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.
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Patent Agency Ranking
公开(公告)号：US20150246031A1
公开(公告)日：2015-09-03
申请号：US14715682
申请日：2015-05-19
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Eleni Dokou , Shahla Jamzad , John P. Caesar, JR. , Majed Fawaz , Laura Das , Chong-Hui Gu , Patricia Nell Hurter , Meghna Jai lsrani , Meghan M. Johnston , Dragutin Knezic , Andrew G. Kuzmission , HongRen Wang
CPC classification number: A61K9/205 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/47 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , C07D215/56
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
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公开(公告)号：US20140255483A1
公开(公告)日：2014-09-11
申请号：US14286856
申请日：2014-05-23
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Eleni Dokou , Shahla Jamzad , John P. Caesar, JR. , Majed Fawaz , Laura Das , Chong-Hui Gu , Patricia Nell Hurter , Meghna Jai Israni , Meghan M. Johnston , Dragutin Knezic , Andrew G. Kuzmission , HongRen Wang
IPC: C07D215/56 , A61K9/20 , A61K9/16
CPC classification number: A61K9/205 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/47 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , C07D215/56
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
Abstract translation: 本发明涉及含有N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，其包括 粉末，颗粒和微型片剂的固体分散体，粉末的制造和加工方法，颗粒和微型片剂，以及使用该药物组合物治疗囊性纤维化的方法。
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公开(公告)号：US11752106B2
公开(公告)日：2023-09-12
申请号：US17475622
申请日：2021-09-15
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Eleni Dokou , Shahla Jamzad , John P. Caesar, Jr. , Majed Fawaz , Laura Das , Chong-Hui Gu , Patricia Nell Hurter , Meghna Jai Israni , Meghan M. Johnston , Dragutin Knezic , Andrew G. Kuzmission , HongRen Wang
IPC: A61K9/20 , A61K9/14 , A61K9/16 , A61K9/48 , A61K31/47 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , C07D215/56 , A61P1/10 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/06 , A61P3/10 , A61P3/12 , A61P5/00 , A61P5/14 , A61P5/16 , A61P5/18 , A61P7/00 , A61P7/04 , A61P7/10 , A61P7/12 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/02 , A61P13/12 , A61P15/08 , A61P15/10 , A61P17/00 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/28 , A61P27/02 , A61P27/04 , A61P29/00 , A61P31/10 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , A61K47/00
CPC classification number: A61K9/205 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/485 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K31/47 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , C07D215/56
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
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公开(公告)号：US11147770B2
公开(公告)日：2021-10-19
申请号：US16299675
申请日：2019-03-12
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Eleni Dokou , Shahla Jamzad , John P. Caesar, Jr. , Majed Fawaz , Laura Das , Chong-Hui Gu , Patricia Nell Hurter , Meghna Jai Israni , Meghan M. Johnston , Dragutin Knezic , Andrew G. Kuzmission , Hongren Wang
IPC: A61K9/20 , A61K9/14 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , A61K9/16 , C07D215/56 , A61K9/48 , A61K31/47 , A61P3/10 , A61P9/00 , A61P7/12 , A61P7/10 , A61P7/04 , A61P7/00 , A61P5/16 , A61P5/18 , A61P5/14 , A61P5/00 , A61P43/00 , A61P37/08 , A61P37/06 , A61P3/06 , A61P35/00 , A61P31/10 , A61P31/12 , A61P3/00 , A61P29/00 , A61P27/04 , A61P27/02 , A61P25/28 , A61P25/22 , A61P25/20 , A61P25/16 , A61P25/14 , A61P25/08 , A61P25/00 , A61P21/04 , A61P21/02 , A61P21/00 , A61P19/10 , A61P19/08 , A61P17/00 , A61P15/10 , A61P15/08 , A61P13/12 , A61P13/02 , A61P11/06 , A61P11/02 , A61P11/00 , A61P1/18 , A61P1/16 , A61P1/10
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
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公开(公告)号：US08883206B2
公开(公告)日：2014-11-11
申请号：US14286856
申请日：2014-05-23
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Eleni Dokou , Shahla Jamzad , John P. Caesar, Jr. , Majed Fawaz , Laura Das , Chong-Hui Gu , Patricia Nell Hurter , Meghna Jai Israni , Meghan M. Johnston , Dragutin Knezic , Andrew G. Kuzmission , HongRen Wang
CPC classification number: A61K9/205 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/47 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , C07D215/56
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
Abstract translation: 本发明涉及含有N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，其包括 粉末，颗粒和微型片剂的固体分散体，粉末的制造和加工方法，颗粒和微型片剂，以及使用该药物组合物治疗囊性纤维化的方法。
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