公开(公告)号：US10231932B2

公开(公告)日：2019-03-19

申请号：US15035969

申请日：2014-10-31

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： Kelly Ann Swinney ,  Patricia Nell Hurter ,  David E. Nadig ,  David Smith ,  Vance Hayden Thomas ,  Martin Paul Warman

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K31/47 ,  A61K45/06 ,  A61K31/443

Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.