公开(公告)号：US11512160B2

公开(公告)日：2022-11-29

申请号：US15578633

申请日：2016-06-02

申请人： University of Washington

发明人： Shaoyi Jiang ,  Tao Bai ,  Jean-René Ella-Menye ,  Hsiang-Chieh Hung ,  Priyesh Jain ,  Andrew Sinclair ,  Harihara Subramanian Sundaram ,  Yang Li ,  Peng Zhang

IPC分类号： C08F220/34 ,  C08F220/36 ,  C08F220/48 ,  C08F220/44 ,  C08F220/50 ,  C08F220/42 ,  C08F220/60 ,  A61K47/58 ,  A61K47/59 ,  C07F9/09 ,  C07C229/16 ,  C07C265/04 ,  C07C229/12 ,  C07C255/23 ,  C07C237/22 ,  C07C253/30 ,  C07C255/26 ,  C09D5/16 ,  C09D7/65 ,  C08G18/38 ,  C08G18/78 ,  C08G61/08 ,  C08G61/12 ,  C08G63/685 ,  C08G69/26 ,  C08G69/42 ,  C08G73/02 ,  C08G73/06 ,  C08L35/02 ,  C08L65/00 ,  C08L67/02 ,  C08L75/04 ,  C08L77/06 ,  C08L79/02 ,  C08L79/04 ,  C09D135/02 ,  C09D165/00 ,  C09D167/02 ,  C09D175/04 ,  C09D177/06 ,  C09D179/02 ,  C09D179/04 ,  C08G61/06 ,  C08G63/00 ,  C08F222/32

摘要： Free-standing non-fouling polymers and polymeric compositions, monomers and macromonomers for making the polymers and polymeric compositions, objects made from the polymers and polymeric compositions, and methods for making and using the polymers and polymeric compositions.

公开(公告)号：US20210171783A1

公开(公告)日：2021-06-10

申请号：US17268310

申请日：2019-08-14

申请人： University of Washington

发明人： Shaoyi Jiang ,  Hsiang-Chieh Hung ,  Dianyu Dong ,  Caroline Tsao ,  Chenjue Tang ,  Joel MacArthur

IPC分类号： C09D5/16 ,  C08J3/24 ,  C08J3/075 ,  A61L29/14 ,  A61L27/52 ,  A61L31/14 ,  A61L31/10 ,  A61L29/08 ,  A61L27/34

摘要： Zwitterionic double network hydrogels, methods for making zwitterionic double network hydrogels, methods for using zwitterionic double network hydrogels, and articles made from and coated with zwitterionic double network hydrogels.

公开(公告)号：US20200253192A1

公开(公告)日：2020-08-13

申请号：US16320433

申请日：2017-07-20

申请人： UNIVERSITY OF WASHINGTON

发明人： Shaoyi Jiang ,  Andrew Sinclair ,  Mary Elizabeth O'Kelly ,  Tao Bai ,  Priyesh Jain

IPC分类号： A01N1/02

摘要： Zwitterionic microgels, zwitterionic microgel assemblies, their formulations and methods for their use.

公开(公告)号：US10301413B2

公开(公告)日：2019-05-28

申请号：US14698721

申请日：2015-04-28

申请人： University of Washington

发明人： Shaoyi Jiang ,  Shengfu Chen

IPC分类号： A61K31/665 ,  C08F220/10 ,  A61K38/10 ,  C08F220/26 ,  C08F220/34 ,  B29C39/20 ,  C08L51/04 ,  C08F222/10

摘要： Nonfouling copolymers and hydrogels comprising positively charged repeating units or latent positively charged repeating units and negatively charged units or latent positively charged units.

公开(公告)号：US10272180B2

公开(公告)日：2019-04-30

申请号：US15509607

申请日：2015-09-09

申请人： University of Washington

发明人： Shaoyi Jiang ,  Tao Bai ,  Harihara Subramanian Sundaram ,  Andrew William Sinclair ,  Jean-René Ella-Menye ,  Priyesh Jain

IPC分类号： A61L27/52 ,  C08G81/02 ,  A61F2/00 ,  A61K9/00 ,  A61L15/24 ,  A61L31/14 ,  A61L15/22 ,  A61L15/42 ,  A61L24/00 ,  A61L24/04 ,  A61L27/16 ,  A61L27/38 ,  A61L31/06 ,  A61L31/10 ,  C08F220/36 ,  C12N5/00 ,  A61K47/58

摘要： Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.

公开(公告)号：US20190041410A1

公开(公告)日：2019-02-07

申请号：US16047911

申请日：2018-07-27

申请人： University of Washington through its Center for Commercialization ,  Bloodworks

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N21/77

CPC分类号： G01N33/80 ,  G01N21/75 ,  G01N21/7703 ,  G01N33/54373

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US10073102B2

公开(公告)日：2018-09-11

申请号：US15436585

申请日：2017-02-17

申请人： University of Washington through its Center for Commercialization ,  Bloodworks

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N33/543 ,  G01N21/77

CPC分类号： G01N33/80 ,  G01N21/75 ,  G01N21/7703 ,  G01N33/54373

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US09738780B2

公开(公告)日：2017-08-22

申请号：US15211278

申请日：2016-07-15

申请人： University of Washington through its Center for Commercialization

发明人： Shaoyi Jiang ,  Hong Xue ,  Wei Yang ,  Louisa R. Carr

IPC分类号： C08L33/14 ,  A61K41/00 ,  A61L27/34 ,  A61L27/52 ,  A61L31/10 ,  C07C229/12 ,  A61L29/08 ,  A61L29/14 ,  A61L31/14 ,  C08F26/02 ,  C08L33/10 ,  C08J3/075 ,  C12Q1/54

CPC分类号： C08L33/14 ,  A61K41/0019 ,  A61L27/34 ,  A61L27/52 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  C07C229/12 ,  C08F26/02 ,  C08J3/075 ,  C08J2433/14 ,  C08L33/10 ,  C08L2201/54 ,  C08L2312/00 ,  C12Q1/54 ,  C12Y101/03004 ,  G01N2333/904 ,  Y10T428/31786

摘要： Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

公开(公告)号：US20170227555A1

公开(公告)日：2017-08-10

申请号：US15436585

申请日：2017-02-17

申请人： University of Washington through its Center for Commercialization ,  Puget Sound Blood Center

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N21/77 ,  G01N33/543

CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US09535062B2

公开(公告)日：2017-01-03

申请号：US14470775

申请日：2014-08-27

申请人： University of Washington

发明人： Shaoyi Jiang ,  Zheng Zhang ,  Shengfu Chen ,  Hana Vaisocherova

IPC分类号： G01N33/545 ,  G01N33/543 ,  C08F122/22

CPC分类号： G01N33/545 ,  C08F122/22 ,  G01N33/54353

摘要： Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.

摘要翻译： 双功能非结垢表面和材料，用于制造双功能非结垢表面和材料的方法，以及包括双功能非结垢表面和材料的装置。 双功能表面是抵抗非特异性蛋白质吸附和细胞粘附的非结垢表面。 双功能表面和材料包括向其赋予特定生物活性的共价偶联的生物分子（例如靶结合配偶体）。 表面和材料可用于医学诊断，生物材料和生物处理，组织工程和药物递送。