公开(公告)号：US20210171783A1

公开(公告)日：2021-06-10

申请号：US17268310

申请日：2019-08-14

申请人： University of Washington

发明人： Shaoyi Jiang ,  Hsiang-Chieh Hung ,  Dianyu Dong ,  Caroline Tsao ,  Chenjue Tang ,  Joel MacArthur

IPC分类号： C09D5/16 ,  C08J3/24 ,  C08J3/075 ,  A61L29/14 ,  A61L27/52 ,  A61L31/14 ,  A61L31/10 ,  A61L29/08 ,  A61L27/34

摘要： Zwitterionic double network hydrogels, methods for making zwitterionic double network hydrogels, methods for using zwitterionic double network hydrogels, and articles made from and coated with zwitterionic double network hydrogels.

公开(公告)号：US20210324010A1

公开(公告)日：2021-10-21

申请号：US17283708

申请日：2019-10-10

申请人： University of Washington

发明人： Caroline Tsao ,  Sijin Luozhong ,  Trevor Corrigan ,  Shaoyi Jiang ,  Erik Liu ,  Patrick McMullen

IPC分类号： C07K14/00 ,  A61K47/64 ,  C07K14/535 ,  C07K14/56 ,  C07K14/435

摘要： Charged polypeptides, their conjugates, and fusion proteins comprising such polypeptides are disclosed. Inclusion of such a polypeptide in a fusion protein increases the protein's properties such as stability and circulation half-life, which results in a better therapeutic efficacy compared to an active protein alone. Thus, a fusion protein or a conjugate of the disclosure can be useful in developing a protein or peptide drug, treating or preventing diseases, disorders, or conditions, or improving a subjects health or wellbeing.