公开(公告)号：US20150203622A1

公开(公告)日：2015-07-23

申请号：US14539449

申请日：2014-11-12

Applicant: Boston Scientific Scimed, Inc. ,  University of Massachusetts Lowell

Inventor： Mark Boden ,  Marlene C. Schwarz ,  Frederick H. Strickler ,  Rudolf Faust ,  Umaprasana Ojha ,  Tomoya Higashihara

IPC: C08F299/04

CPC classification number: C08F299/04 ,  A61L27/165 ,  A61L27/54 ,  A61L27/58 ,  A61L29/041 ,  A61L29/148 ,  A61L29/16 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G18/4266 ,  C08G18/6204 ,  C08G18/7671 ,  C08G63/00 ,  C08G63/06 ,  C08G63/912 ,  C08G64/18 ,  C08G64/42 ,  C08G69/08 ,  C08G2261/126 ,  C08L53/02

Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.

Abstract translation: 本发明涉及具有一个或多个聚异丁烯链段和一个或多个生物可降解聚合物链段的共聚物，制备这种共聚物的方法，含有这种共聚物的医药制品，以及制备这种医疗制品的方法。 根据本发明的某些方面，提供了包含多个聚异丁烯链段和多个可生物降解的聚合物链段的共聚物。 根据本发明的某些方面，提供了共聚物，其包含氨基甲酸酯键，脲键，酰胺键，酯键，酸酐键，碳酸酯键，通常描述为“点击”化学键的键，以及两种或更多种类型 这样的联系。

公开(公告)号：US08962785B2

公开(公告)日：2015-02-24

申请号：US13681811

申请日：2012-11-20

Applicant: University of Massachusetts Lowell

Inventor： Rudolf Faust ,  Umaprasana Ojha

IPC: C08G18/32 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L29/04 ,  A61L29/06 ,  A61L29/08 ,  A61L31/06 ,  A61L31/10 ,  C08G18/40 ,  C08G18/48 ,  C08G18/62 ,  C08G18/65 ,  C08G18/76

CPC classification number: C08G18/6204 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L29/049 ,  A61L29/06 ,  A61L29/085 ,  A61L31/06 ,  A61L31/10 ,  C08G18/32 ,  C08G18/3206 ,  C08G18/4063 ,  C08G18/4854 ,  C08G18/6511 ,  C08G18/7671 ,  C08L75/04

Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.

Abstract translation: 一种弹性体聚合物，其包含（1）所述弹性体聚合物的10至60重量％的硬链段，其中所述硬链段包括氨基甲酸酯，脲或氨基脲; 和（2）弹性体聚合物的40重量％至90重量％的软链段。 软链段包含（a）至少2重量％的至少一个聚醚大分子二醇的软链段和/或至少一个聚碳酸酯大分子二醇; 和（b）至少2重量％的至少一种聚异丁烯大分子二醇和/或二胺的软链段。

公开(公告)号：US09631042B2

公开(公告)日：2017-04-25

申请号：US14539449

申请日：2014-11-12

Applicant: Boston Scientific Scimed, Inc. ,  University of Massachusetts Lowell

Inventor： Mark Boden ,  Marlene C. Schwarz ,  Frederick H. Strickler ,  Rudolf Faust ,  Umaprasana Ojha ,  Tomoya Higashihara

IPC: C08F299/04 ,  A61L27/16 ,  A61L27/54 ,  A61L27/58 ,  A61L29/04 ,  A61L29/14 ,  A61L29/16 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  C08G18/42 ,  C08G18/62 ,  C08G18/76 ,  C08G63/00 ,  C08G63/91 ,  C08G63/06 ,  C08G64/18 ,  C08G64/42 ,  C08G69/08

CPC classification number: C08F299/04 ,  A61L27/165 ,  A61L27/54 ,  A61L27/58 ,  A61L29/041 ,  A61L29/148 ,  A61L29/16 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G18/4266 ,  C08G18/6204 ,  C08G18/7671 ,  C08G63/00 ,  C08G63/06 ,  C08G63/912 ,  C08G64/18 ,  C08G64/42 ,  C08G69/08 ,  C08G2261/126 ,  C08L53/02

Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.

公开(公告)号：US11174336B2

公开(公告)日：2021-11-16

申请号：US16706363

申请日：2019-12-06

Applicant: University of Massachusetts Lowell

Inventor： Rudolf Faust ,  Umaprasana Ojha

IPC: C08G18/62 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L29/04 ,  A61L29/06 ,  A61L29/08 ,  A61L31/06 ,  A61L31/10 ,  C08G18/40 ,  C08G18/48 ,  C08G18/65 ,  C08G18/76 ,  C08G18/32

Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.