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公开(公告)号：US20170369905A1
公开(公告)日：2017-12-28
申请号：US15534735
申请日：2015-12-11
Applicant: University of Copenhagen , Novo Nordisk A/S
Inventor： Henrik Clausen , Zhang Yang , Adnan Fevzi Halim , Eric Bennett , Carsten Behrens , Malene Bech Vester-Christensen , Shamim Herbert Rahman
IPC: C12N15/90 , C12P21/00 , C07K14/505 , C07K16/46
CPC classification number: C12N15/907 , C07K14/505 , C07K16/464 , C07K2317/24 , C07K2317/56 , C12N2501/24 , C12N2501/724 , C12N2511/00 , C12P21/005
Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
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公开(公告)号：US11708569B2
公开(公告)日：2023-07-25
申请号：US17272178
申请日：2019-08-29
Applicant: University of Copenhagen , GLYCODISPLAY APS
Inventor： Claus Kristensen , Weihua Tian , Henrik Clausen , Zhang Yang , Sergey Vakhrushev
CPC classification number: C12N9/2465 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: The present invention relates to lysosomal enzymes modified by use of cell based methods, a compositions comprising a modified lysosomal enzyme, as well as methods for producing a modified lysosomal enzyme and therapeutic use of such modified lysosomal enzyme. In particular, the present disclosure relates to a modified lysosomal enzyme which has low Man6P and low exposed Mannose and high sialic acid content of alpha2,3 type enabling long circulation time and improved uptake into difficult-to-reach organs like heart, kidney and brain.
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Patent Agency Ranking
公开(公告)号：US20210102223A1
公开(公告)日：2021-04-08
申请号：US17090677
申请日：2020-11-05
Applicant: University of Copenhagen , Danmarks Tekniske Universitet
Inventor： Henrik Clausen , Zhang Yang , Adnan Fevzi Halim , Eric Bennett , Carsten Behrens , Malene Bech Vester-Christensen , Shamim Herbert Rahman
IPC: C12N15/90 , C12P21/00 , C07K14/505 , C07K16/46
Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
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公开(公告)号：US10858671B2
公开(公告)日：2020-12-08
申请号：US15534735
申请日：2015-12-11
Applicant: University of Copenhagen , DANMARKS TEKNISKE UNIVERSITET
Inventor： Henrik Clausen , Zhang Yang , Adnan Fevzi Halim , Eric Bennett , Carsten Behrens , Malene Bech Vester-Christensen , Shamim Herbert Rahman
IPC: C12N15/90 , C12P21/00 , C07K14/505 , C07K16/46
Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
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公开(公告)号：US10889845B2
公开(公告)日：2021-01-12
申请号：US15745300
申请日：2016-06-15
Applicant: UNIVERSITY OF COPENHAGEN , DANMARKS TEKNISKE UNIVERSITET
Inventor： Shamim Herbert Rahman , Carsten Behrens , Malene Bech Vester-Christensen , Henrik Clausen , Zhang Yang , Adnan Fevzi Halim , Eric Bennett
IPC: A61K48/00 , C07H21/04 , C12P21/00 , C07K14/505 , C07K14/61 , C07K16/00 , C12N15/90 , C12N9/64 , C12N5/00 , C12N5/071
Abstract: The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.
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公开(公告)号：US20210095317A1
公开(公告)日：2021-04-01
申请号：US17090706
申请日：2020-11-05
Applicant: University of Copenhagen , Danmarks Tekniske Universitet
Inventor： Henrik Clausen , Zhang Yang , Adnan Fevzi Halim , Eric Bennett , Carsten Behrens , Malene Bech Vester-Christensen , Shamim Herbert Rahman
IPC: C12N15/90 , C12P21/00 , C07K14/505 , C07K16/46
Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
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公开(公告)号：US20210087587A1
公开(公告)日：2021-03-25
申请号：US17090746
申请日：2020-11-05
Applicant: University of Copenhagen , Danmarks Tekniske Universitet
Inventor： Henrik Clausen , Zhang Yang , Adnan Fevzi Halim , Eric Bennett , Carsten Behrens , Malene Bech Vester-Christensen , Shamim Herbert Rahman
IPC: C12N15/90 , C12P21/00 , C07K14/505 , C07K16/46
Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.
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