公开(公告)号：US10889845B2

公开(公告)日：2021-01-12

申请号：US15745300

申请日：2016-06-15

Applicant: UNIVERSITY OF COPENHAGEN ,  DANMARKS TEKNISKE UNIVERSITET

Inventor： Shamim Herbert Rahman ,  Carsten Behrens ,  Malene Bech Vester-Christensen ,  Henrik Clausen ,  Zhang Yang ,  Adnan Fevzi Halim ,  Eric Bennett

IPC: A61K48/00 ,  C07H21/04 ,  C12P21/00 ,  C07K14/505 ,  C07K14/61 ,  C07K16/00 ,  C12N15/90 ,  C12N9/64 ,  C12N5/00 ,  C12N5/071

Abstract: The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.

公开(公告)号：US20210102223A1

公开(公告)日：2021-04-08

申请号：US17090677

申请日：2020-11-05

Applicant: University of Copenhagen ,  Danmarks Tekniske Universitet

Inventor： Henrik Clausen ,  Zhang Yang ,  Adnan Fevzi Halim ,  Eric Bennett ,  Carsten Behrens ,  Malene Bech Vester-Christensen ,  Shamim Herbert Rahman

IPC: C12N15/90 ,  C12P21/00 ,  C07K14/505 ,  C07K16/46

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

公开(公告)号：US10858671B2

公开(公告)日：2020-12-08

申请号：US15534735

申请日：2015-12-11

Applicant: University of Copenhagen ,  DANMARKS TEKNISKE UNIVERSITET

Inventor： Henrik Clausen ,  Zhang Yang ,  Adnan Fevzi Halim ,  Eric Bennett ,  Carsten Behrens ,  Malene Bech Vester-Christensen ,  Shamim Herbert Rahman

IPC: C12N15/90 ,  C12P21/00 ,  C07K14/505 ,  C07K16/46

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

公开(公告)号：US20210095317A1

公开(公告)日：2021-04-01

申请号：US17090706

申请日：2020-11-05

Applicant: University of Copenhagen ,  Danmarks Tekniske Universitet

Inventor： Henrik Clausen ,  Zhang Yang ,  Adnan Fevzi Halim ,  Eric Bennett ,  Carsten Behrens ,  Malene Bech Vester-Christensen ,  Shamim Herbert Rahman

IPC: C12N15/90 ,  C12P21/00 ,  C07K14/505 ,  C07K16/46

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

公开(公告)号：US20210087587A1

公开(公告)日：2021-03-25

申请号：US17090746

申请日：2020-11-05

Applicant: University of Copenhagen ,  Danmarks Tekniske Universitet

Inventor： Henrik Clausen ,  Zhang Yang ,  Adnan Fevzi Halim ,  Eric Bennett ,  Carsten Behrens ,  Malene Bech Vester-Christensen ,  Shamim Herbert Rahman

IPC: C12N15/90 ,  C12P21/00 ,  C07K14/505 ,  C07K16/46

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.

公开(公告)号：US20170369905A1

公开(公告)日：2017-12-28

申请号：US15534735

申请日：2015-12-11

Applicant: University of Copenhagen ,  Novo Nordisk A/S

Inventor： Henrik Clausen ,  Zhang Yang ,  Adnan Fevzi Halim ,  Eric Bennett ,  Carsten Behrens ,  Malene Bech Vester-Christensen ,  Shamim Herbert Rahman

IPC: C12N15/90 ,  C12P21/00 ,  C07K14/505 ,  C07K16/46

CPC classification number: C12N15/907 ,  C07K14/505 ,  C07K16/464 ,  C07K2317/24 ,  C07K2317/56 ,  C12N2501/24 ,  C12N2501/724 ,  C12N2511/00 ,  C12P21/005

Abstract: The present invention relates to a mammalian cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprising one or more posttranslational modification patterns. These modifications are useful for example in glycoprotein production where the antibodies with the modifications have an enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). The present invention also relates to methods for producing the glycoproteins and compositions comprising the glycoproteins, and their uses.