公开(公告)号：US12064759B2

公开(公告)日：2024-08-20

申请号：US17245381

申请日：2021-04-30

申请人： NUtech Ventures ,  UNIVERSITY OF CONNECTICUT

发明人： Ruiguo Yang ,  Arian Jaberi ,  Amir Monemian Esfahani ,  Ali Tamayol

IPC分类号： B01L3/00 ,  C12M1/34 ,  C12N1/34

CPC分类号： B01L3/5025 ,  C12M41/46 ,  C12N1/34 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/0883 ,  C12N2513/00

摘要： Microfluidic gradient generators that can create robust platforms that can not only be used for creating co-cultures of cells with various ratios, but also can simultaneously generate gradients of mechanical and chemical stresses. A chip utilizes microchambers embedded within channels to provide space for 3D cell culture and exposes these cells to gradients of mechanical shear stress and a chemical treatment.

公开(公告)号：US12011878B2

公开(公告)日：2024-06-18

申请号：US17570431

申请日：2022-01-07

申请人： University Of Connecticut

发明人： Ali Tamayol ,  Mohamadmahdi Samandari ,  Jacob Quint

IPC分类号： B29C64/336 ,  B29C48/02 ,  B29C64/118 ,  B29C64/209 ,  B33Y10/00 ,  B33Y30/00

CPC分类号： B29C64/336 ,  B29C48/02 ,  B29C64/118 ,  B29C64/209 ,  B33Y10/00 ,  B33Y30/00

摘要： A multi-material printer can include a housing that is configured to be handheld. The housing can be configured to receive first and second printable materials from respective first and second containers. A nozzle can define an outlet of the multi-material printer. At least one actuator can be configured to cause first and second printable materials from the first and second containers to flow at a respective constant rate. The multi-material printer can be configured to simultaneously extrude the first and second printable materials from the outlet. The multi-material printer can be used for fabricating a scaffold from filaments comprising the first and second materials directly within the body of a human or animal.

公开(公告)号：US20240197965A1

公开(公告)日：2024-06-20

申请号：US18285602

申请日：2022-04-08

申请人： University of Connecticut

发明人： Ali Tamayol ,  Mohamadmahdi Samandari ,  Azadeh Mostafavi ,  Nasim Annabi ,  Indranil Sinha ,  Jacob Quint ,  Mehdi Kazemzadeh Narbat

IPC分类号： A61L27/56 ,  A61L26/00 ,  A61L27/26

CPC分类号： A61L27/56 ,  A61L26/0052 ,  A61L26/0085 ,  A61L27/26 ,  A61L2300/414 ,  A61L2430/30

摘要： A foam biomaterial is disclosed. The foam biomaterial includes a biomaterial ink having an interconnected pore structure. The foam biomaterial can have a porosity from about 10% to about 90%. Systems and methods for forming and depositing the foam biomaterial are also disclosed. In exemplary applications, the foam biomaterial can be deposited on or within a body of a subject or patient.

公开(公告)号：US20240189476A1

公开(公告)日：2024-06-13

申请号：US18535288

申请日：2023-12-11

申请人： University of Connecticut

发明人： Ali Tamayol ,  Mohamadmahdi Samandari ,  Farnoosh Saeedinejad ,  Jacob P. Quint ,  Elmira Arab Tehrany-Kahn ,  Cyril Kahn

IPC分类号： A61L27/22 ,  A61L27/56 ,  A61L27/58 ,  B33Y70/00

CPC分类号： A61L27/227 ,  A61L27/56 ,  A61L27/58 ,  B33Y70/00

摘要： A biomaterial composition includes an uncrosslinked plant-based biomaterial functionalized with reactive groups that are operative to undergo a crosslinking reaction via free radical polymerization. A method for producing a biomaterial composition includes functionalizing an uncrosslinked plant-based biomaterial with reactive groups that are operative to undergo a crosslinking reaction via free radical polymerization to form a functionalized uncrosslinked plant-based biomaterial. Additional embodiments are provided.

公开(公告)号：US20240050727A1

公开(公告)日：2024-02-15

申请号：US18449499

申请日：2023-08-14

申请人： University of Connecticut

发明人： Ali Tamayol ,  Mohamadmahdi Samandari ,  Steven Toro ,  Jacob Quint

IPC分类号： A61M37/00

CPC分类号： A61M37/0015 ,  A61M2205/3368 ,  A61M2205/106 ,  A61M2205/3633 ,  A61M2037/003 ,  A61M2207/10

摘要： A device and method for generating in-situ microneedles in a subject. The device includes a body, a microneedle coupled to the body, a reservoir coupled to the body, a first motor. The microneedle is positioned within a chamber at a distal end of the body. The reservoir includes a biomaterial fluid and is in fluid communication with the microneedle. The first motor is configured to activate the reservoir to expel the biomaterial fluid to the microneedle. The device also includes a temperature control assembly coupled to the reservoir and configured to set and maintain a temperature of the reservoir, a second motor coupled to the body and the microneedle, a microneedle size device coupled to the microneedle and configured to set a length of the microneedle extending from the chamber. Lastly, the device includes a user interface configured to receive input from a user to control the microneedle to penetrate the tissue to inject the biomaterial fluid into the tissue to generate an in-situ microneedle in the tissue.

公开(公告)号：US20220354998A1

公开(公告)日：2022-11-10

申请号：US17738936

申请日：2022-05-06

申请人： University of Connecticut

发明人： Ali Tamayol ,  Lindsay Barnum

IPC分类号： A61L31/14 ,  A61M37/00 ,  A61L31/16 ,  A61L31/04 ,  B33Y80/00 ,  B33Y40/20 ,  B29C64/35

摘要： Disclosed herein are drug delivery devices that can temporally and spatially deliver biologically active agents. An example drug delivery device includes a microneedle array comprising a plurality of microneedles on a surface of a substrate, each microneedle comprising a core comprising a hydrogel and a layer on a surface of the core. Also disclosed are methods of using the drug delivery device, and methods of making the microneedle array that includes a loading device.

公开(公告)号：US20220212410A1

公开(公告)日：2022-07-07

申请号：US17570431

申请日：2022-01-07

申请人： University Of Connecticut

发明人： Ali Tamayol ,  Mohamadmahdi Samandari ,  Jacob Quint

IPC分类号： B29C64/336 ,  B29C64/118 ,  B29C64/209 ,  B29C48/02 ,  B33Y10/00 ,  B33Y30/00

摘要： A multi-material printer can include a housing that is configured to be handheld. The housing can be configured to receive first and second printable materials from respective first and second containers. A nozzle can define an outlet of the multi-material printer. At least one actuator can be configured to cause first and second printable materials from the first and second containers to flow at a respective constant rate. The multi-material printer can be configured to simultaneously extrude the first and second printable materials from the outlet. The multi-material printer can be used for fabricating a scaffold from filaments comprising the first and second materials directly within the body of a human or animal.

公开(公告)号：US20210339242A1

公开(公告)日：2021-11-04

申请号：US17245381

申请日：2021-04-30

申请人： Board of Regents of the University of Nebraska ,  UNIVERSITY OF CONNECTICUT

发明人： Ruiguo Yang ,  Arian Jaberi ,  Amir Monemian Esfahani ,  Ali Tamayol

IPC分类号： B01L3/00 ,  C12N1/34 ,  C12M1/34

摘要： Microfluidic gradient generators that can create robust platforms that can not only be used for creating co-cultures of cells with various ratios, but also can simultaneously generate gradients of mechanical and chemical stresses. A chip utilizes microchambers embedded within channels to provide space for 3D cell culture and exposes these cells to gradients of mechanical shear stress and a chemical treatment.