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    DNA-antigen exchange and amplification
    1.
    发明授权
    DNA-antigen exchange and amplification 有权

    公开(公告)号：US10246738B2

    公开(公告)日：2019-04-02

    申请号：US15941770

    申请日：2018-03-30

    申请人： Ultivue, Inc.

    发明人： Stephanie Rae Hennek ,  Mael Manesse

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12Q1/682 ,  C12Q1/6804 ,  G01N33/58 ,  C12Q1/6844 ,  G01N33/53

    摘要： Methods for imaging are described, including, but not limited to a method comprising: (1) contacting a sample being tested for the presence of one or more targets with one or more target-specific binding partners, wherein each target-specific binding partner is linked to a docking strand, and wherein target-specific binding partners of different specificity are linked to different docking strands, (2) optionally removing unbound target-specific binding partners, (3) contacting the sample with antigen-bound imager strands and antigen-specific binding partners linked (directly or indirectly) to optical labels, wherein the antigen-bound imager strands have complementarity to a docking strand, directly or indirectly, and wherein each antigen-specific binding partner is linked to one or more optical labels, and wherein antigen-specific binding partners of different specificity are linked to distinct optical labels, (4) optionally removing unbound antigen-bound imager strands and/or antigen-specific binding partners, (5) imaging the sample to detect bound labeled antigen-specific binding partners, (6) optionally removing/extinguishing signal from the optical labels, and (7) optionally repeating steps (1)-(7), or any subset thereof.

    DNA-Antigen Exchange and Amplification
    2.
    发明公开
    DNA-Antigen Exchange and Amplification 审中-公开

    公开(公告)号：US20240182952A1

    公开(公告)日：2024-06-06

    申请号：US18419885

    申请日：2024-01-23

    申请人： Ultivue, Inc.

    发明人： Stephanie Rae Hennek ,  Mael Manesse

    IPC分类号： C12Q1/682 ,  C12Q1/6804 ,  C12Q1/6844 ,  G01N33/53 ,  G01N33/58

    CPC分类号： C12Q1/682 ,  C12Q1/6804 ,  C12Q1/6844 ,  G01N33/5308 ,  G01N33/582 ,  G01N2458/10

    摘要： Methods for imaging are described, including, but not limited to a method comprising: (1) contacting a sample being tested for the presence of one or more targets with one or more target-specific binding partners, wherein each target-specific binding partner is linked to a docking strand, and wherein target-specific binding partners of different specificity are linked to different docking strands, (2) optionally removing unbound target-specific binding partners, (3) contacting the sample with antigen-bound imager strands and antigen-specific binding partners linked (directly or indirectly) to optical labels, wherein the antigen-bound imager strands have complementarity to a docking strand, directly or indirectly, and wherein each antigen-specific binding partner is linked to one or more optical labels, and wherein antigen-specific binding partners of different specificity are linked to distinct optical labels, (4) optionally removing unbound antigen-bound imager strands and/or antigen-specific binding partners, (5) imaging the sample to detect bound labeled antigen-specific binding partners, (6) optionally removing/extinguishing signal from the optical labels, and (7) optionally repeating steps (1)-(6), or any subset thereof.

    DNA-antigen exchange and amplification
    4.
    发明授权
    DNA-antigen exchange and amplification 有权

    公开(公告)号：US11279968B2

    公开(公告)日：2022-03-22

    申请号：US16273581

    申请日：2019-02-12

    申请人： Ultivue, Inc.

    发明人： Stephanie Rae Hennek ,  Mael Manesse

    IPC分类号： C12Q1/682 ,  C12Q1/6804 ,  G01N33/58 ,  C12Q1/6844 ,  G01N33/53

    摘要： Methods for imaging are described, including, but not limited to a method comprising: (1) contacting a sample being tested for the presence of one or more targets with one or more target-specific binding partners, wherein each target-specific binding partner is linked to a docking strand, and wherein target-specific binding partners of different specificity are linked to different docking strands, (2) optionally removing unbound target-specific binding partners, (3) contacting the sample with antigen-bound imager strands and antigen-specific binding partners linked (directly or indirectly) to optical labels, wherein the antigen-bound imager strands have complementarity to a docking strand, directly or indirectly, and wherein each antigen-specific binding partner is linked to one or more optical labels, and wherein antigen-specific binding partners of different specificity are linked to distinct optical labels, (4) optionally removing unbound antigen-bound imager strands and/or antigen-specific binding partners, (5) imaging the sample to detect bound labeled antigen-specific binding partners, (6) optionally removing/extinguishing signal from the optical labels, and (7) optionally repeating steps (1)-(6), or any subset thereof.

    DNA-antigen exchange and amplification
    5.
    发明授权
    DNA-antigen exchange and amplification 有权

    公开(公告)号：US11920186B2

    公开(公告)日：2024-03-05

    申请号：US17668665

    申请日：2022-02-10

    申请人： Ultivue, Inc.

    发明人： Stephanie Rae Hennek ,  Mael Manesse

    IPC分类号： C12Q1/682 ,  C12Q1/6804 ,  C12Q1/6844 ,  G01N33/58 ,  G01N33/53

    CPC分类号： C12Q1/682 ,  C12Q1/6804 ,  C12Q1/6844 ,  G01N33/5308 ,  G01N33/582 ,  G01N2458/10 ,  C12Q1/682 ,  C12Q2531/125

    摘要： Methods for imaging are described, including, but not limited to a method comprising: (1) contacting a sample being tested for the presence of one or more targets with one or more target-specific binding partners, wherein each target-specific binding partner is linked to a docking strand, and wherein target-specific binding partners of different specificity are linked to different docking strands, (2) optionally removing unbound target-specific binding partners, (3) contacting the sample with antigen-bound imager strands and antigen-specific binding partners linked (directly or indirectly) to optical labels, wherein the antigen-bound imager strands have complementarity to a docking strand, directly or indirectly, and wherein each antigen-specific binding partner is linked to one or more optical labels, and wherein antigen-specific binding partners of different specificity are linked to distinct optical labels, (4) optionally removing unbound antigen-bound imager strands and/or antigen-specific binding partners, (5) imaging the sample to detect bound labeled antigen-specific binding partners, (6) optionally removing/extinguishing signal from the optical labels, and (7) optionally repeating steps (1)-(6), or any subset thereof.