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公开(公告)号：US5852176A
公开(公告)日：1998-12-22
申请号：US915495
申请日：1997-08-20
IPC分类号： G01N33/53 , A61K31/00 , A61K38/00 , A61K39/395 , A61P37/00 , A61P37/02 , A61P37/04 , C07H21/04 , C07K14/52 , C07K14/54 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/566
CPC分类号： C07K16/2866 , C07K14/7155 , A61K38/00 , Y10S930/12
摘要： Antibodies to human IL-12 beta 2 receptor protein or an IL-12 receptor complex, the complex comprising the beta1 receptor protein complexed with a beta2 receptor protein, which complex is capable of binding to human IL-12 with high affinity.
摘要翻译： 对人IL-12β2受体蛋白或IL-12受体复合物的抗体，该复合物包含与β2受体蛋白复合的β1受体蛋白，该复合物能够以高亲和力结合人IL-12。
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公开(公告)号：US5840530A
公开(公告)日：1998-11-24
申请号：US685118
申请日：1996-07-23
IPC分类号： G01N33/53 , A61K31/00 , A61K38/00 , A61K39/395 , A61P37/00 , A61P37/02 , A61P37/04 , C07H21/04 , C07K14/52 , C07K14/54 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/566 , C12N15/03 , C12N15/11
CPC分类号： C07K16/2866 , C07K14/7155 , A61K38/00 , Y10S930/12
摘要： A recombinant human IL-12 beta2 receptor protein produced on the surface of a non-human mammalian cell, free from other human proteins, in its active form. In addition, a non-human mammalian cell having expressed on its surface the recombinant human IL-12 beta2 receptor protein, which cell proliferates in the presence of human IL-12. A non-human mammalian cell having the human IL-12 beta2 receptor protein on its surface and which proliferates in response to human IL-12 is useful for determining whether a given compound inhibits biological activity of human IL-12 or is an IL-12 agonist.
摘要翻译： 在非活性形式的非人哺乳动物细胞表面上产生的，不含其他人类蛋白质的重组人IL-12β2受体蛋白质。 另外，在其表面上表达了人IL-12的重组人IL-12β2受体蛋白的非人哺乳动物细胞，该细胞在人IL-12存在下增殖。 在其表面上具有人IL-12β2受体蛋白的非人哺乳动物细胞，其响应于人IL-12增殖是有用的，用于确定给定的化合物是否抑制人IL-12的生物活性或是IL-12 激动剂。
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公开(公告)号：US5919903A
公开(公告)日：1999-07-06
申请号：US914520
申请日：1997-08-19
IPC分类号： G01N33/53 , A61K31/00 , A61K38/00 , A61K39/395 , A61P37/00 , A61P37/02 , A61P37/04 , C07H21/04 , C07K14/52 , C07K14/54 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/566
CPC分类号： C07K16/2866 , C07K14/7155 , A61K38/00 , Y10S930/12
摘要： A recombinant human IL-12 receptor complex produced on the surface of a non-human mammalian cell and free from other human proteins, the complex comprising the beta1 receptor protein complexed with a beta2 receptor protein, which complex is capable of binding to human IL-12 with high affinity. A recombinant human IL-12 beta2 receptor protein produced on the surface of a non-human mammalian cell, free from other human proteins, in its active form. In addition, a non-human mammalian cell having expressed on its surface the recombinant human IL-12 beta2 receptor protein or the recombinant human IL-12 receptor complex, which cell proliferates in the presence of human IL-12. A non-human mammalian cell having the human IL-12 beta2 receptor protein or the complex expressed on its surface and which proliferates in response to human IL-12 is useful for determining whether a given compound inhibits biological activity of human IL-12 or is an IL-12 agonist.
摘要翻译： 在非人哺乳动物细胞的表面上产生并且不含其它人类蛋白质的重组人IL-12受体复合物，所述复合物包含与β2受体蛋白质复合的β1受体蛋白，该复合物能够结合人IL- 12具有高亲和力。 在非活性形式的非人哺乳动物细胞表面上产生的，不含其他人类蛋白质的重组人IL-12β2受体蛋白质。 此外，已经在其表面上表达了人IL-12β2受体蛋白或重组人IL-12受体复合物的非人哺乳动物细胞，该细胞在人IL-12存在下增殖。 具有人IL-12β2受体蛋白或其表面上表达并且响应于人IL-12增殖的复合物的非人哺乳动物细胞可用于确定给定化合物是否抑制人IL-12的生物活性或是 IL-12激动剂。
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公开(公告)号：US5831007A
公开(公告)日：1998-11-03
申请号：US419652
申请日：1995-04-11
IPC分类号： A61K38/00 , C07K14/715 , C07K16/28
CPC分类号： C07K16/2866 , C07K14/7155 , A61K38/00
摘要： This invention relates to substantially pure Interleukin-12 receptor cDNAs and protein and uses therefore. The Interleukin-12 receptor is shown to be a member of the cytokine receptor superfamily and has a high homology to human gp130.
摘要翻译： 本发明涉及基本上纯的白细胞介素-12受体cDNA和蛋白质，因此有用。 白细胞介素-12受体显示为细胞因子受体超家族的成员，与人gp130具有高度同源性。
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公开(公告)号：US20100261191A1
公开(公告)日：2010-10-14
申请号：US12820358
申请日：2010-06-22
IPC分类号： C12Q1/68
CPC分类号： G01N33/5008 , C07K14/705 , C12N2503/00 , C12N2510/00 , G01N33/5014 , G01N33/502 , G01N33/6872 , G01N2800/52
摘要： A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided.
摘要翻译： 提供了表达hERG并在电生理测试条件下表现出稳定电流的稳定的真核细胞系。
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公开(公告)号：US08349572B2
公开(公告)日：2013-01-08
申请号：US12820358
申请日：2010-06-22
IPC分类号： C12Q1/00
CPC分类号： G01N33/5008 , C07K14/705 , C12N2503/00 , C12N2510/00 , G01N33/5014 , G01N33/502 , G01N33/6872 , G01N2800/52
摘要： A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided.
摘要翻译： 提供了表达hERG并在电生理测试条件下表现出稳定电流的稳定的真核细胞系。
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7.发明授权Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto 失效细胞毒性淋巴细胞成熟因子及其单克隆抗体的纯化和表征公开(公告)号：US08110187B2
公开(公告)日：2012-02-07
申请号：US10267565
申请日：2002-10-08
申请人： Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
发明人： Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K14/5434 , A61K38/00 , C07K16/24 , C07K16/244 , Y10S530/806
摘要： The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergistically induces with low concentrations of IL-2 the cytolytic activity of Lymphokine Activated Killer (LAK) cells, and CLMF is capable of stimulating T-cell growth.Also claimed are the cloned gene for CLMF, its recombination in a suitable vector, the transformed cells containing said vector, the recombinant protein produced by the transformed cells and antibodies to CLMF.
摘要翻译： 本发明是由人类NC-37B淋巴母细胞细胞（American Type Culture Collection，Rockville，Md。）生产和合成的称为IL-12或细胞毒性淋巴细胞成熟因子（CLMF）的新型细胞因子蛋白质。 CLMF协同诱导低浓度的IL-2淋巴因子活化杀伤（LAK）细胞的细胞溶解活性，CLMF能够刺激T细胞生长。 还要求的是用于CLMF的克隆基因，其在合适载体中的重组，含有所述载体的转化细胞，由转化细胞产生的重组蛋白和针对CLMF的抗体。
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公开(公告)号：US07776590B2
公开(公告)日：2010-08-17
申请号：US11637511
申请日：2006-12-11
CPC分类号： G01N33/5008 , C07K14/705 , C12N2503/00 , C12N2510/00 , G01N33/5014 , G01N33/502 , G01N33/6872 , G01N2800/52
摘要： A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided.
摘要翻译： 提供了表达hERG并在电生理测试条件下表现出稳定电流的稳定的真核细胞系。
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9.发明授权Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto 失效细胞毒性淋巴细胞成熟因子及其单克隆抗体的纯化和表征公开(公告)号：US06683046B1
公开(公告)日：2004-01-27
申请号：US08459151
申请日：1995-06-02
申请人： Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
发明人： Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
IPC分类号： C07K1400
CPC分类号： C07K16/24 , A61K38/00 , C07K14/5434 , C07K16/244
摘要： The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergistically induces with low concentrations of IL-2 the cytolytic activity of Lymphokine Activated Killer (LAK) cells, and CLMF is capable of stimulating T-cell growth. Also claimed are the cloned gene for CLMF, its recombination in a suitable vector, the transformed cells containing said vector, the recombinant protein produced by the transformed cells and antibodies to CLMF.
摘要翻译： 本发明是由人类NC-37B淋巴母细胞细胞（American Type Culture Collection，Rockville，Md。）生产和合成的称为IL-12或细胞毒性淋巴细胞成熟因子（CLMF）的新型细胞因子蛋白质。 CLMF协同诱导低浓度的IL-2淋巴因子活化杀伤（LAK）细胞的细胞溶解活性，CLMF能够刺激T细胞生长。 还要求的是用于CLMF的克隆基因，其在合适载体中的重组，含有所述载体的转化细胞，由转化细胞产生的重组蛋白和针对CLMF的抗体。
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公开(公告)号：US5780597A
公开(公告)日：1998-07-14
申请号：US460061
申请日：1995-06-02
申请人： Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
发明人： Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
CPC分类号： C07K14/5434 , C07K16/24 , C07K16/244 , A61K38/00 , Y10S530/806
摘要： The present invention relates to antibodies which bind to a novel cytotoxic lymphocyte maturation factor. When bound to the cytotoxic lymphocyte maturation factor, the antibodies can neutralize bioactivity of the factor.
摘要翻译： 本发明涉及结合新型细胞毒性淋巴细胞成熟因子的抗体。 当与细胞毒性淋巴细胞成熟因子结合时，抗体可以中和该因子的生物活性。
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