发明授权
- 专利标题： Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
- 专利标题（中）： 细胞毒性淋巴细胞成熟因子及其单克隆抗体的纯化和表征
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申请号： US10267565申请日： 2002-10-08
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公开(公告)号： US08110187B2公开(公告)日： 2012-02-07
- 发明人: Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
- 申请人： Maurice Kent Gately , Ulrich Andreas Gubler , Jeffrey David Hulmes , Frank John Podlaski , Alvin Seth Stern , Richard Anthony Chizzonite , Yu-Ching Eugene Pan
- 申请人地址： US NJ Nutley
- 专利权人： Hoffman-La Roche Inc.
- 当前专利权人： Hoffman-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理机构： Yankwich & Associates, P.C.
- 代理商 Leon R. Yankwich; Thomas R. Berka
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/24
摘要：
The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergistically induces with low concentrations of IL-2 the cytolytic activity of Lymphokine Activated Killer (LAK) cells, and CLMF is capable of stimulating T-cell growth.Also claimed are the cloned gene for CLMF, its recombination in a suitable vector, the transformed cells containing said vector, the recombinant protein produced by the transformed cells and antibodies to CLMF.
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