公开(公告)号：US20210137149A1

公开(公告)日：2021-05-13

申请号：US17009382

申请日：2020-09-01

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Sebastian BRANDHORST ,  Valter D. LONGO ,  Min WEI

IPC分类号： A23L33/00 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L23/10 ,  A23L2/52 ,  A23F3/40 ,  A23L23/00 ,  A23L19/00 ,  A23L25/00 ,  A23L2/38 ,  A61K36/00 ,  A23L33/115

摘要： A fasting mimicking diet package providing daily meal portions for a predetermined number of days is provided. The fasting mimicking diet package includes a kale cracker composition, a first vegetable broth composition, a mushroom soup composition, a tomato soup composition, a quinoa-containing minestrone soup composition, a bean-containing minestrone soup composition, and a pumpkin soup composition. Characteristically, the daily meal portions are packaged into meal servings or into a total daily serving to be divided into meals.

公开(公告)号：US20200345053A1

公开(公告)日：2020-11-05

申请号：US16863418

申请日：2020-04-30

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Valter D. LONGO ,  Min WEI ,  Priya RANGAN

IPC分类号： A23L33/20 ,  A61K9/00 ,  A61K47/26 ,  A61K47/42 ,  A61K47/44

摘要： A method of treating Alzheimer's associated pathology includes a step of identifying subject having a pathology that is associated with Alzheimer's disease. A fasting mimicking diet (FMD) is then administered to the subject for a first time period. Methods for treating amyloid plaque formation and/or elevated levels of tau protein as well as neuroinflammation are also provided.

公开(公告)号：US20210177032A1

公开(公告)日：2021-06-17

申请号：US17182676

申请日：2021-02-23

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Valter D. LONGO ,  Chia-Wei CHENG ,  Sebastian BRANDHORST ,  Min WEI

IPC分类号： A23L33/00 ,  A61K45/00 ,  A23L29/30 ,  A23L33/115 ,  A23L33/175 ,  A23L33/17 ,  A23L33/16 ,  A23L33/15 ,  A23L33/155

摘要： A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day.

公开(公告)号：US20170342063A1

公开(公告)日：2017-11-30

申请号：US14913130

申请日：2016-02-12

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Valter D. LONGO ,  Priya BALASUBRAMANIAN ,  Nouri NEAMATI ,  Min WEI

IPC分类号： C07D413/12 ,  C07D307/68 ,  C07D405/14 ,  C07K16/28 ,  C07K16/26 ,  C07D405/12 ,  A61K39/00

CPC分类号： C07D413/12 ,  A61K31/4245 ,  A61K31/55 ,  A61K45/06 ,  A61K2039/505 ,  A61P25/00 ,  A61P35/00 ,  C07D307/68 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07K16/26 ,  C07K16/2869 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/75 ,  C07K2317/76

摘要： Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.

公开(公告)号：US20190276445A1

公开(公告)日：2019-09-12

申请号：US16366662

申请日：2019-03-27

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Valter D. LONGO ,  Priya BALASUBRAMANIAN ,  Nouri NEAMATI ,  Min WEI

IPC分类号： C07D413/12 ,  A61P35/00 ,  A61K45/06 ,  A61P25/00 ,  A61K31/4245 ,  A61K31/55 ,  C07D405/06 ,  C07D307/68 ,  C07K16/26 ,  C07D405/14 ,  C07K16/28 ,  C07D405/12

摘要： Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.

公开(公告)号：US20140112909A1

公开(公告)日：2014-04-24

申请号：US14060494

申请日：2013-10-22

申请人： University of Southern California

发明人： Valter D. LONGO ,  Chia Wei CHENG ,  Sebastian BRANDHORST ,  Min WEI

IPC分类号： A23L1/29 ,  A61K45/00

CPC分类号： A23L33/40 ,  A23L29/37 ,  A23L33/115 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/17 ,  A23L33/175 ,  A23L33/30 ,  A23V2002/00 ,  A61K45/00

摘要： A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day.

摘要翻译： 一种方法包括识别需要饮食修饰的受试者的步骤; 以及对所述受试者施用第一次饮食第一次。 第一次饮食在头一天的第二天至第五天每天每磅主题每天提供4.5至7千卡每天的主题，每天每磅3至5千卡。 第一天的饮食包括第一天少于30克的糖; 第二至第五天少于20克糖; 第一天少于28克蛋白质; 第二至第五天天数少于18克; 第一天20至30克单不饱和脂肪; 第二至第五天10至15克单不饱和脂肪; 和第一天6至10克多不饱和脂肪之间。

公开(公告)号：US20230078881A1

公开(公告)日：2023-03-16

申请号：US17982067

申请日：2022-11-07

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Valter D. LONGO ,  Min WEI ,  Priya RANGAN

IPC分类号： A61K35/747 ,  A23L33/135 ,  A23L3/44 ,  A61K9/16 ,  A61K9/48 ,  A61K35/745

摘要： A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.