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    PRECURSOR-DIRECTED BIOSYNTHESIS OF 5-HYDROXYTRYPTOPHAN
    2.
    发明申请
    PRECURSOR-DIRECTED BIOSYNTHESIS OF 5-HYDROXYTRYPTOPHAN 有权
    5-羟基磷酸酯的前体指导生物合成

    公开(公告)号：US20160060638A1

    公开(公告)日：2016-03-03

    申请号：US14809712

    申请日：2015-07-27

    申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

    发明人： Yajun Yan ,  Xinxiao Sun

    IPC分类号： C12N15/70 ,  C12N9/02 ,  C12P13/22

    CPC分类号： C12N9/0073 ,  C12N9/0071 ,  C12N9/1022 ,  C12N9/1077 ,  C12N9/1085 ,  C12N9/1205 ,  C12N9/1294 ,  C12N9/88 ,  C12P13/04 ,  C12P13/227 ,  C12Y114/13

    摘要： The invention provides compounds, compositions, non-naturally occurring organisms, and methods useful for production of 5-hydroxytryptophan (5-HTP) in a microbial cell. A microbial system which includes at least one microbial cell, such as a bacterial cell or a yeast cell, is genetically engineered to express all or a portion of non-naturally occurring biosynthetic pathway that catalyzes the conversion of a simple carbon source, such as glucose, to 5-HTP. The invention can result in improved titers of 5-HTP and permits low-cost, large scale production. Methods of making and using the genetically engineered cells are also included in the invention.

    摘要翻译： 本发明提供了可用于在微生物细胞中生产5-羟色氨酸（5-HTP）的化合物，组合物，非天然存在的生物和方法。 包括至少一个微生物细胞如细菌细胞或酵母细胞的微生物系统被遗传工程化以表达催化简单碳源如葡萄糖转化的全部或部分非天然存在的生物合成途径 ，至5-HTP。 本发明可以提高5-HTP的滴度，并允许低成本，大规模生产。 制造和使用遗传工程细胞的方法也包括在本发明中。

    Genetically engineered microbes and methods for producing 4-hydroxycoumarin
    7.
    发明授权
    Genetically engineered microbes and methods for producing 4-hydroxycoumarin 有权
    遗传工程微生物和生产4-羟基香豆素的方法

    公开(公告)号：US09353390B2

    公开(公告)日：2016-05-31

    申请号：US14304105

    申请日：2014-06-13

    申请人： University of Georgia Research Foundation, Inc.

    发明人： Yajun Yan ,  Yuheng Lin

    IPC分类号： C12P17/06 ,  C07D311/46 ,  C07D311/56 ,  C12N15/52

    CPC分类号： C12P17/06 ,  C07D311/46 ,  C07D311/56 ,  C12N15/52

    摘要： Provided herein are methods for the biosynthesis of 4-hydroxycoumarin. In one embodiment, provided herein are genetically engineered microbes that include a metabolic pathway for the production of 4-hydroxycoumarin. Also provided are methods for using the genetically engineered microbes to produce 4-hydroxycoumarin, and using the 4-hydroxycoumarin as the starting point for the synthesis of other compounds.

    摘要翻译： 本文提供了4-羟基香豆素的生物合成方法。 在一个实施方案中，本文提供了包含用于生产4-羟基香豆素的代谢途径的遗传工程微生物。 还提供了使用遗传工程微生物来生产4-羟基香豆素的方法，并且使用4-羟基香豆素作为合成其它化合物的起始点。