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公开(公告)号：US11919950B2
公开(公告)日：2024-03-05
申请号：US17122752
申请日：2020-12-15
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
CPC classification number: C07K16/244 , C07K2317/33 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号：US11292831B2
公开(公告)日：2022-04-05
申请号：US16772043
申请日：2018-12-13
Applicant: UCB Biopharma SRL
Inventor： Patrick Downey , Kerry Louise Tyson , Marco Kriek , Lorenzo De Lichtervelde , Daniel John Lightwood , David James McMillan , Peter Charles Elliott , Terence Seward Baker
Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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公开(公告)号：US11261242B2
公开(公告)日：2022-03-01
申请号：US16771993
申请日：2018-12-13
Applicant: UCB Biopharma SRL
Inventor： Ralph Adams , Patrick Downey , Terence Seward Baker , Kerry Louise Tyson , Lorenzo De Lichtervelde , Daniel John Lightwood , David James McMillan
Abstract: The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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公开(公告)号：US11942188B2
公开(公告)日：2024-03-26
申请号：US16823055
申请日：2020-03-18
Applicant: UCB Biopharma SRL
Inventor： Jiye Shi , Terence Seward Baker , Alastair David Griffiths Lawson , Xiaofeng Liu
CPC classification number: G16B5/00 , C07K16/244 , G16B15/30 , G16C20/50 , G16C20/90 , C07K2317/55 , C07K2317/76 , G16B15/00
Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.
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公开(公告)号：US20220073581A1
公开(公告)日：2022-03-10
申请号：US17259090
申请日：2019-07-10
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Terence Seward Baker , Xiaofeng Liu
IPC: C07K14/54 , C07K16/24 , C07K16/18 , C07K16/28 , C07K14/55 , C07K14/535 , C07K14/505
Abstract: The present invention provides antibodies comprising a variable (V) domain and an insert polypeptide, wherein the insert polypeptide is within the framework 3 region of the V domain.
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Patent Agency Ranking
公开(公告)号：US20210309734A1
公开(公告)日：2021-10-07
申请号：US17122752
申请日：2020-12-15
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
IPC: C07K16/24
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号：US20210005277A1
公开(公告)日：2021-01-07
申请号：US16823055
申请日：2020-03-18
Applicant: UCB Biopharma SRL
Inventor： Jiye Shi , Terence Seward Baker , Alastair David Griffiths Lawson , Xiaofeng Liu
Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.
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公开(公告)号：US20240376191A1
公开(公告)日：2024-11-14
申请号：US18422323
申请日：2024-01-25
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
IPC: C07K16/24
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号：US20240352083A1
公开(公告)日：2024-10-24
申请号：US18647911
申请日：2024-04-26
Applicant: UCB Biopharma SRL
Inventor： Ralph Adams , Terence Seward Baker , Xiaofeng Liu
IPC: C07K14/54 , C07K14/505 , C07K14/535 , C07K14/55 , C07K16/18 , C07K16/24 , C07K16/28
CPC classification number: C07K14/5443 , C07K14/505 , C07K14/535 , C07K14/5428 , C07K14/55 , C07K16/18 , C07K16/244 , C07K16/248 , C07K16/2809 , C07K16/2818 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/76
Abstract: The present invention provides antibodies comprising a variable (V) domain and an insert polypeptide, wherein the insert polypeptide is within the framework 3 region of the V domain.
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公开(公告)号：US11746145B2
公开(公告)日：2023-09-05
申请号：US17136440
申请日：2020-12-29
Applicant: UCB BIOPHARMA SRL
Inventor： Kerry Louise Tyson , Terence Seward Baker , Georges Mairet-Coello , Patrick Downey , Jean-Philippe Courade , David Edward Ormonde Knight
CPC classification number: C07K16/18 , A61P25/28 , C07K14/4711 , G01N33/6896 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92 , G01N2333/4703 , G01N2800/28 , G01N2800/2821
Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.
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