公开(公告)号：US11746145B2

公开(公告)日：2023-09-05

申请号：US17136440

申请日：2020-12-29

Applicant: UCB BIOPHARMA SRL

Inventor： Kerry Louise Tyson ,  Terence Seward Baker ,  Georges Mairet-Coello ,  Patrick Downey ,  Jean-Philippe Courade ,  David Edward Ormonde Knight

IPC: C07K16/18 ,  C07K14/47 ,  A61P25/28 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61P25/28 ,  C07K14/4711 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N2333/4703 ,  G01N2800/28 ,  G01N2800/2821

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US11292831B2

公开(公告)日：2022-04-05

申请号：US16772043

申请日：2018-12-13

Applicant: UCB Biopharma SRL

Inventor： Patrick Downey ,  Kerry Louise Tyson ,  Marco Kriek ,  Lorenzo De Lichtervelde ,  Daniel John Lightwood ,  David James McMillan ,  Peter Charles Elliott ,  Terence Seward Baker

IPC: C07K16/18 ,  A61P25/16 ,  A61K39/00

Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

公开(公告)号：US11261242B2

公开(公告)日：2022-03-01

申请号：US16771993

申请日：2018-12-13

Applicant: UCB Biopharma SRL

Inventor： Ralph Adams ,  Patrick Downey ,  Terence Seward Baker ,  Kerry Louise Tyson ,  Lorenzo De Lichtervelde ,  Daniel John Lightwood ,  David James McMillan

IPC: C07K16/18 ,  A61K39/00

Abstract: The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

公开(公告)号：US11732034B2

公开(公告)日：2023-08-22

申请号：US17136189

申请日：2020-12-29

Applicant: UCB BIOPHARMA SRL

Inventor： David Edward Ormonde Knight ,  Terence Seward Baker ,  David James McMillan ,  Robert Anthony Griffin ,  Georges Mairet-Coello ,  Patrick Downey ,  Jean-Philippe Courade

IPC: C07K16/18 ,  C07K14/47 ,  A61P25/28

CPC classification number: C07K16/18 ,  A61P25/28 ,  C07K14/4711 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US10906966B2

公开(公告)日：2021-02-02

申请号：US16458217

申请日：2019-07-01

Applicant: UCB BIOPHARMA SRL

Inventor： Kerry Louise Tyson ,  Terence Seward Baker ,  Georges Mairet-Coello ,  Patrick Downey ,  Jean-Philippe Courade ,  David Edward Ormonde Knight

IPC: C07K16/18 ,  C07K14/47 ,  A61P25/28 ,  G01N33/68 ,  A61K39/00

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.