公开(公告)号：US11292831B2

公开(公告)日：2022-04-05

申请号：US16772043

申请日：2018-12-13

Applicant: UCB Biopharma SRL

Inventor： Patrick Downey ,  Kerry Louise Tyson ,  Marco Kriek ,  Lorenzo De Lichtervelde ,  Daniel John Lightwood ,  David James McMillan ,  Peter Charles Elliott ,  Terence Seward Baker

IPC: C07K16/18 ,  A61P25/16 ,  A61K39/00

Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.