公开(公告)号：US11174311B2

公开(公告)日：2021-11-16

申请号：US16470999

申请日：2017-12-13

Applicant: UCB BIOPHARMA SRL ,  SANOFI

Inventor： Alastair David Griffiths Lawson ,  Daniel John Lightwood ,  Rebecca Jayne Munro ,  James Philip O'Connell ,  John Robert Porter

IPC: C07K16/24

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US11919950B2

公开(公告)日：2024-03-05

申请号：US17122752

申请日：2020-12-15

Applicant: UCB BIOPHARMA SRL

Inventor： Ralph Adams ,  Terence Seward Baker ,  Alastair David Griffiths Lawson

IPC: C12N15/09 ,  C07K16/24

CPC classification number: C07K16/244 ,  C07K2317/33 ,  C07K2317/92

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：US11942188B2

公开(公告)日：2024-03-26

申请号：US16823055

申请日：2020-03-18

Applicant: UCB Biopharma SRL

Inventor： Jiye Shi ,  Terence Seward Baker ,  Alastair David Griffiths Lawson ,  Xiaofeng Liu

IPC: G16C20/50 ,  C07K16/24 ,  G16B5/00 ,  G16B15/00 ,  G16B15/30 ,  G16C20/90

CPC classification number: G16B5/00 ,  C07K16/244 ,  G16B15/30 ,  G16C20/50 ,  G16C20/90 ,  C07K2317/55 ,  C07K2317/76 ,  G16B15/00

Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.

公开(公告)号：US20230074381A1

公开(公告)日：2023-03-09

申请号：US17804934

申请日：2022-06-01

Applicant: UCB Biopharma SRL

Inventor： Helene Margaret Finney ,  Alastair David Griffiths Lawson ,  Stevan Graham Shaw ,  Bryan John Smith ,  Kerry Louise Tyson ,  Lara Kevorkian ,  Christoph Meier ,  Kaushik Sarkar ,  Paul Alan Atherfold

IPC: C07K16/28 ,  G01N33/50 ,  G01N33/564 ,  G01N33/68 ,  A61K47/60 ,  A61K47/64 ,  A61K39/395

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

公开(公告)号：US20210309734A1

公开(公告)日：2021-10-07

申请号：US17122752

申请日：2020-12-15

Applicant: UCB BIOPHARMA SRL

Inventor： Ralph Adams ,  Terence Seward Baker ,  Alastair David Griffiths Lawson

IPC: C07K16/24

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：US20210005277A1

公开(公告)日：2021-01-07

申请号：US16823055

申请日：2020-03-18

Applicant: UCB Biopharma SRL

Inventor： Jiye Shi ,  Terence Seward Baker ,  Alastair David Griffiths Lawson ,  Xiaofeng Liu

IPC: G16B5/00 ,  G16C20/90 ,  G16C20/50 ,  C07K16/24

Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.

公开(公告)号：US20240376191A1

公开(公告)日：2024-11-14

申请号：US18422323

申请日：2024-01-25

Applicant: UCB BIOPHARMA SRL

Inventor： Ralph Adams ,  Terence Seward Baker ,  Alastair David Griffiths Lawson

IPC: C07K16/24

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.