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公开(公告)号：US11261242B2
公开(公告)日：2022-03-01
申请号：US16771993
申请日：2018-12-13
Applicant: UCB Biopharma SRL
Inventor： Ralph Adams , Patrick Downey , Terence Seward Baker , Kerry Louise Tyson , Lorenzo De Lichtervelde , Daniel John Lightwood , David James McMillan
Abstract: The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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公开(公告)号：US12054559B2
公开(公告)日：2024-08-06
申请号：US17541932
申请日：2021-12-03
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Thomas Allen Ceska , Anna Marie Davies , Alistair James Henry , Xiaofeng Liu , James Michael McDonnell , Brian John Sutton , Marta Katarzyna Westwood
IPC: C07K16/42 , A61P37/08 , C07K14/735 , C07K16/28
CPC classification number: C07K16/4291 , A61P37/08 , C07K14/70535 , C07K16/2851 , C07K2317/565 , C07K2317/92
Abstract: The present invention relates to the area of improved anti-IgE antibodies and antigen binding agents, and compositions thereof, which target IgE, for instance: for use in treating disorders caused by IgE (such as allergic responses, or certain autoimmune responses); and, in particular, disorders caused by the interaction of IgE with the FcεRI receptor. In particular, this invention relates to improved anti-IgE antibodies and antigen binding agents related to novel mutants of omalizumab (Xolair®). The improved anti-IgE antibodies and antigen binding agents of the invention may have improved affinity for IgE and/or an improved interaction with the Cε2 domain of IgE and/or an improved modified epitope on IgE (for instance further involving the Cε2 domain of IgE) and/or the ability to disassociate IgE from the FcεRI receptor for instance at pharmaceutically-relevant concentrations. In one aspect, improved or novel treatments for IgE mediated disorders are disclosed in which IgE is targeted (for instance free IgE and/or IgE complexed with the FcεRI receptor).
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公开(公告)号：US11999772B2
公开(公告)日：2024-06-04
申请号：US17259090
申请日：2019-07-10
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Terence Seward Baker , Xiaofeng Liu
IPC: C07K16/00 , C07K14/505 , C07K14/535 , C07K14/54 , C07K14/55 , C07K16/18 , C07K16/24 , C07K16/28
CPC classification number: C07K14/5443 , C07K14/505 , C07K14/535 , C07K14/5428 , C07K14/55 , C07K16/18 , C07K16/244 , C07K16/248 , C07K16/2809 , C07K16/2818 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/76
Abstract: The present invention provides antibodies comprising a variable (V) domain and an insert polypeptide, wherein the insert polypeptide is within the framework 3 region of the V domain.
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公开(公告)号：US11091542B2
公开(公告)日：2021-08-17
申请号：US16063133
申请日：2016-12-14
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Pallavi Bhatta , Emma Dave , Sam Philip Heywood , David Paul Humphreys , Diane Marshall , Daniel John Lightwood
Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号：US20240376191A1
公开(公告)日：2024-11-14
申请号：US18422323
申请日：2024-01-25
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
IPC: C07K16/24
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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Patent Agency Ranking
公开(公告)号：US20240352083A1
公开(公告)日：2024-10-24
申请号：US18647911
申请日：2024-04-26
Applicant: UCB Biopharma SRL
Inventor： Ralph Adams , Terence Seward Baker , Xiaofeng Liu
IPC: C07K14/54 , C07K14/505 , C07K14/535 , C07K14/55 , C07K16/18 , C07K16/24 , C07K16/28
CPC classification number: C07K14/5443 , C07K14/505 , C07K14/535 , C07K14/5428 , C07K14/55 , C07K16/18 , C07K16/244 , C07K16/248 , C07K16/2809 , C07K16/2818 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/76
Abstract: The present invention provides antibodies comprising a variable (V) domain and an insert polypeptide, wherein the insert polypeptide is within the framework 3 region of the V domain.
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公开(公告)号：US20220073581A1
公开(公告)日：2022-03-10
申请号：US17259090
申请日：2019-07-10
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Terence Seward Baker , Xiaofeng Liu
IPC: C07K14/54 , C07K16/24 , C07K16/18 , C07K16/28 , C07K14/55 , C07K14/535 , C07K14/505
Abstract: The present invention provides antibodies comprising a variable (V) domain and an insert polypeptide, wherein the insert polypeptide is within the framework 3 region of the V domain.
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公开(公告)号：US20210309734A1
公开(公告)日：2021-10-07
申请号：US17122752
申请日：2020-12-15
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
IPC: C07K16/24
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号：US11919950B2
公开(公告)日：2024-03-05
申请号：US17122752
申请日：2020-12-15
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
CPC classification number: C07K16/244 , C07K2317/33 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号：US20230084464A1
公开(公告)日：2023-03-16
申请号：US17787039
申请日：2020-12-18
Applicant: UCB BIOPHARMA SRL
Inventor： Daniel John Lightwood , Ralph Adams , Roger Thomas Palframan
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing the antibody molecules.
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