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    Multispecific antibody constructs
    2.
    发明授权
    Multispecific antibody constructs 有权

    公开(公告)号：US11345760B2

    公开(公告)日：2022-05-31

    申请号：US15321055

    申请日：2015-06-25

    Applicant: UCB BIOPHARMA SRL

    Inventor： Pallavi Bhatta ,  Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

    IPC: C07K16/46

    Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.

    MULTISPECIFIC ANTIBODY CONSTRUCTS
    3.
    发明申请
    MULTISPECIFIC ANTIBODY CONSTRUCTS 有权

    公开(公告)号：US20220267476A1

    公开(公告)日：2022-08-25

    申请号：US17734253

    申请日：2022-05-02

    Applicant: UCB BIOPHARMA SRL

    Inventor： Pallavi Bhatta ,  Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

    IPC: C07K16/46

    Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.

    Recombinant bacterial host cell for protein expression
    4.
    发明授权
    Recombinant bacterial host cell for protein expression 有权

    公开(公告)号：US11261470B2

    公开(公告)日：2022-03-01

    申请号：US15959498

    申请日：2018-04-23

    Applicant: UCB BIOPHARMA SRL

    Inventor： Philip Jonathan Bassett ,  David Paul Humphreys ,  Pareshkumar Manjibhai Patel

    IPC: C12P21/00 ,  C12P21/02 ,  C12N9/52 ,  C07K16/28 ,  C12N15/70

    Abstract: The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti FcRn antibodies and proteins made by the methods described herein.

    ANTIBODY FRAMEWORKS FOR REDUCING AGGREGATION OF MULTISPECIFIC ANTIBODIES
    5.
    发明申请
    ANTIBODY FRAMEWORKS FOR REDUCING AGGREGATION OF MULTISPECIFIC ANTIBODIES 有权

    公开(公告)号：US20210324111A1

    公开(公告)日：2021-10-21

    申请号：US16470804

    申请日：2017-12-18

    Applicant: UCB BIOPHARMA SRL

    Inventor： Pallavi Bhatta ,  David Paul Humphreys

    IPC: C07K16/46

    Abstract: The present invention provides a multispecific antibody molecule comprising at least two binding domains each with a variable heavy region VH and a variable light region VL, wherein each binding domain is specific for an antigen and comprises 6 CDRs, characterised in that at least one binding domain comprises a variable heavy region, VHA, having a framework comprising valine at position (5), lysine at position (13), alanine at position (24) and threonine at position (96) with the proviso that CDRH3 in VHA is other than RYYSAMPFAY (SEQ ID NO:29) and a variable light region, VLA, having a framework comprising leucine at position (11) and glutamine at position (103).

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