公开(公告)号：US20230087378A1

公开(公告)日：2023-03-23

申请号：US17786996

申请日：2020-12-18

Applicant: UCB BIOPHARMA SRL

Inventor： Adnan Rahman Khan ,  Sam Philip Heywood ,  David Paul Humphreys ,  Daniel John Lightwood ,  Emma Dave ,  Emily Mary Cairistine Barry ,  Sarah Jayne Stanyon

IPC: C07K16/24 ,  A61P37/08

Abstract: The present invention relates to a multi-specific antibody having specificity for human IL-13, human IL-17A and/or human IL-17F. The invention further relates to methods for producing the multi-specific antibody and to its therapeutic use for the treatment of atopic dermatitis and other diseases.

公开(公告)号：US20230242677A1

公开(公告)日：2023-08-03

申请号：US17787094

申请日：2020-12-18

Applicant: UCB BIOPHARMA SRL

Inventor： Emily Mary Cairistine Barry ,  Emma Dave ,  Sam Philip Heywood

IPC: C07K16/46 ,  C12N15/63 ,  C07K1/22

CPC classification number: C07K16/468 ,  C07K1/22 ,  C12N15/63 ,  C07K2317/31 ,  C07K2317/624

Abstract: Multi-specific Antibodies The present disclosure relates to a multi-specific antibody comprising or consisting of: a) a polypeptide chain of formula (I): VH-CH1-(CH2)-(CH3)-(X)-(V1); and b) a polypeptide chain of formula (II): (V3)-(Z) -VL-CL-(Y)-(V2) wherein the polypeptide chain of formula (II) comprises at least one dsscFv, dsFv, scFv, VH or VHH, and wherein the polypeptide chain of formula (I) comprises a protein A binding domain and wherein the polypeptide chain of formula (II) does not bind protein A. The disclosure also provides polynucleotide sequences encoding said multi-specific antibody, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. The disclosure also provides pharmaceutical formulations comprising same, for example for use in treatment. There is also provided a method of expressing a multi-specific antibody of the present disclosure from a host cell.