公开(公告)号：US20220111049A1

公开(公告)日：2022-04-14

申请号：US17560830

申请日：2021-12-23

Applicant: CONTRAFECT CORPORATION ,  TRELLIS BIOSCIENCE, LLC

Inventor： Angeles Estelles ,  Lawrence M. Kauvar ,  Adam Vigil ,  Michael Wittekind

IPC: A61K39/42 ,  C07K16/10

Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that bind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.

公开(公告)号：US09688744B2

公开(公告)日：2017-06-27

申请号：US14697459

申请日：2015-04-27

Applicant: Trellis Bioscience, LLC

Inventor： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

IPC: A61K39/395 ,  C07K16/08 ,  C07K16/46 ,  A61K39/245 ,  A61K39/00

CPC classification number: C07K16/088 ,  A61K39/245 ,  A61K2039/505 ,  C07K16/08 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

公开(公告)号：US20130122000A1

公开(公告)日：2013-05-16

申请号：US13744299

申请日：2013-01-17

Applicant: Trellis Bioscience, LLC

Inventor： Bruce KEYT ,  Lawrence M. Kauvar ,  Ellen J. Collarini ,  Orit Foord ,  Gizette Sperinde ,  Marjan Fatholahi ,  Hung Nguyen

IPC: C07K16/40

CPC classification number: C07K16/2863 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/32 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

Abstract: Antibodies which specifically bind heregulin-coupled HERS, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.

Abstract translation: 描述了在不同于调节蛋白结合位点的位点上特异性结合随机结合的HERS的抗体。 这些抗体特别可用于治疗癌症。

公开(公告)号：US11725055B2

公开(公告)日：2023-08-15

申请号：US17091526

申请日：2020-11-06

Applicant: Trellis Bioscience, LLC

Inventor： Angeles Estelles ,  Mikhail Gishizky ,  Stefan Ryser ,  Lawrence M. Kauvar

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.

公开(公告)号：US11248040B2

公开(公告)日：2022-02-15

申请号：US16746708

申请日：2020-01-17

Applicant: TRELLIS BIOSCIENCE, LLC

Inventor： Lawrence M. Kauvar ,  Stefan Ryser ,  Angeles Estelles ,  Reyna J. Simon ,  Lauren Opremcak Bakaletz ,  Steven David Goodman

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/12 ,  A61K39/40 ,  A61K45/06 ,  A61K49/00 ,  C07K14/31 ,  G01N33/569 ,  C12Q1/18 ,  G01N33/566 ,  C12N15/86 ,  A61K35/12

Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

公开(公告)号：US10233234B2

公开(公告)日：2019-03-19

申请号：US15144681

申请日：2016-05-02

Applicant: Trellis Bioscience, LLC

Inventor： Lawrence M. Kauvar ,  Stefan Ryser ,  Angeles Estelles ,  Reyna J. Simon ,  Lauren Opremcak Bakaletz ,  Steven David Goodman

IPC: C07K16/42 ,  A61K39/44 ,  C07K16/12 ,  A61K39/40 ,  A61K45/06 ,  A61K49/00 ,  C07K14/31 ,  G01N33/569 ,  C12Q1/18 ,  G01N33/566 ,  A61K39/00

Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

公开(公告)号：US10030069B2

公开(公告)日：2018-07-24

申请号：US15464165

申请日：2017-03-20

Applicant: Trellis Bioscience, LLC ,  Laurie M. Usinger

Inventor： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

IPC: C07K16/08 ,  C07K16/46 ,  A61K39/245 ,  A61K39/00

Abstract: Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

公开(公告)号：US12152068B2

公开(公告)日：2024-11-26

申请号：US17569377

申请日：2022-01-05

Applicant: TRELLIS BIOSCIENCE, LLC

Inventor： Lawrence M. Kauvar ,  Stefan Ryser ,  Angeles Estelles ,  Reyna J. Simon ,  Lauren Opremcak Bakaletz ,  Steven David Goodman

IPC: C07K16/12 ,  A61K35/12 ,  A61K39/00 ,  A61K39/40 ,  A61K45/06 ,  A61K49/00 ,  C07K14/31 ,  C12N15/86 ,  C12Q1/18 ,  G01N33/566 ,  G01N33/569

Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

公开(公告)号：US20210268096A1

公开(公告)日：2021-09-02

申请号：US17168553

申请日：2021-02-05

Applicant: Trellis Bioscience, LLC

Inventor： Milton J. Friedman ,  Lawrence M. Kauvar

IPC: A61K39/12 ,  A61P31/14

Abstract: Improvements to vaccines against RSV include G protein CCD portions complexed with mAb that block interaction with CX3C-R and modified forms of mAb to prolong serum half-life, as well as inhalable vaccines.

公开(公告)号：US09321839B2

公开(公告)日：2016-04-26

申请号：US14475348

申请日：2014-09-02

Applicant: Trellis Bioscience, LLC

Inventor： Bruce Keyt ,  Lawrence M. Kauvar ,  Ellen J. Collarini ,  Orit Foord ,  Gizette Sperinde ,  Marjan Fatholahi ,  Hung Nguyen

IPC: C07H21/04 ,  A61K39/395 ,  C07K16/28 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40

CPC classification number: C07K16/2863 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/32 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

Abstract: Recombinant materials and methods for producing antibodies that specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer that expresses HER3.

Abstract translation: 描述了用于产生特异性结合与胰岛素结合位点不同的位点处的胰岛素依赖型HER3的抗体的重组材料和方法。 这些抗体特别可用于治疗表达HER3的癌症。