公开(公告)号：US11248040B2

公开(公告)日：2022-02-15

申请号：US16746708

申请日：2020-01-17

Applicant: TRELLIS BIOSCIENCE, LLC

Inventor： Lawrence M. Kauvar ,  Stefan Ryser ,  Angeles Estelles ,  Reyna J. Simon ,  Lauren Opremcak Bakaletz ,  Steven David Goodman

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/12 ,  A61K39/40 ,  A61K45/06 ,  A61K49/00 ,  C07K14/31 ,  G01N33/569 ,  C12Q1/18 ,  G01N33/566 ,  C12N15/86 ,  A61K35/12

Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

公开(公告)号：US10233234B2

公开(公告)日：2019-03-19

申请号：US15144681

申请日：2016-05-02

Applicant: Trellis Bioscience, LLC

Inventor： Lawrence M. Kauvar ,  Stefan Ryser ,  Angeles Estelles ,  Reyna J. Simon ,  Lauren Opremcak Bakaletz ,  Steven David Goodman

IPC: C07K16/42 ,  A61K39/44 ,  C07K16/12 ,  A61K39/40 ,  A61K45/06 ,  A61K49/00 ,  C07K14/31 ,  G01N33/569 ,  C12Q1/18 ,  G01N33/566 ,  A61K39/00

Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

公开(公告)号：US10570193B2

公开(公告)日：2020-02-25

申请号：US16181260

申请日：2018-11-05

Applicant: Trellis Bioscience, LLC

Inventor： Lawrence M. Kauvar ,  Stefan Ryser ,  Angeles Estelles ,  Reyna J. Simon ,  Lauren Opremcak Bakaletz ,  Steven David Goodman

IPC: A01N63/00 ,  A61K48/00 ,  A61K39/395 ,  C07K16/12 ,  A61K39/40 ,  A01N63/02 ,  A61K45/06 ,  A61K49/00 ,  C07K14/31 ,  G01N33/569 ,  C12Q1/18 ,  G01N33/566 ,  A61K39/00 ,  C12N15/86 ,  A61K35/12

Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

公开(公告)号：US12152068B2

公开(公告)日：2024-11-26

申请号：US17569377

申请日：2022-01-05

Applicant: TRELLIS BIOSCIENCE, LLC

Inventor： Lawrence M. Kauvar ,  Stefan Ryser ,  Angeles Estelles ,  Reyna J. Simon ,  Lauren Opremcak Bakaletz ,  Steven David Goodman

IPC: C07K16/12 ,  A61K35/12 ,  A61K39/00 ,  A61K39/40 ,  A61K45/06 ,  A61K49/00 ,  C07K14/31 ,  C12N15/86 ,  C12Q1/18 ,  G01N33/566 ,  G01N33/569

Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.