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公开(公告)号：US12152068B2
公开(公告)日：2024-11-26
申请号：US17569377
申请日：2022-01-05
Applicant: TRELLIS BIOSCIENCE, LLC
Inventor： Lawrence M. Kauvar , Stefan Ryser , Angeles Estelles , Reyna J. Simon , Lauren Opremcak Bakaletz , Steven David Goodman
IPC: C07K16/12 , A61K35/12 , A61K39/00 , A61K39/40 , A61K45/06 , A61K49/00 , C07K14/31 , C12N15/86 , C12Q1/18 , G01N33/566 , G01N33/569
Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
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公开(公告)号：US20220111049A1
公开(公告)日：2022-04-14
申请号：US17560830
申请日：2021-12-23
Applicant: CONTRAFECT CORPORATION , TRELLIS BIOSCIENCE, LLC
Inventor： Angeles Estelles , Lawrence M. Kauvar , Adam Vigil , Michael Wittekind
Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that bind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
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3.发明授权公开(公告)号：US11725055B2
公开(公告)日：2023-08-15
申请号：US17091526
申请日：2020-11-06
Applicant: Trellis Bioscience, LLC
Inventor： Angeles Estelles , Mikhail Gishizky , Stefan Ryser , Lawrence M. Kauvar
IPC: C07K16/28 , A61K39/395 , A61K45/06
CPC classification number: C07K16/2803 , A61K39/3955 , A61K45/06 , C07K2317/10 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
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公开(公告)号：US11248040B2
公开(公告)日：2022-02-15
申请号：US16746708
申请日：2020-01-17
Applicant: TRELLIS BIOSCIENCE, LLC
Inventor： Lawrence M. Kauvar , Stefan Ryser , Angeles Estelles , Reyna J. Simon , Lauren Opremcak Bakaletz , Steven David Goodman
IPC: A61K39/00 , A61K39/395 , C07K16/12 , A61K39/40 , A61K45/06 , A61K49/00 , C07K14/31 , G01N33/569 , C12Q1/18 , G01N33/566 , C12N15/86 , A61K35/12
Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
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公开(公告)号：US10233234B2
公开(公告)日：2019-03-19
申请号：US15144681
申请日：2016-05-02
Applicant: Trellis Bioscience, LLC
Inventor： Lawrence M. Kauvar , Stefan Ryser , Angeles Estelles , Reyna J. Simon , Lauren Opremcak Bakaletz , Steven David Goodman
IPC: C07K16/42 , A61K39/44 , C07K16/12 , A61K39/40 , A61K45/06 , A61K49/00 , C07K14/31 , G01N33/569 , C12Q1/18 , G01N33/566 , A61K39/00
Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
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Patent Agency Ranking
公开(公告)号：US11246928B2
公开(公告)日：2022-02-15
申请号：US16674149
申请日：2019-11-05
Applicant: CONTRAFECT CORPORATION , TRELLIS BIOSCIENCE, LLC
Inventor： Angeles Estelles , Lawrence M. Kauvar , Adam Vigil , Michael Wittekind
Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that hind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
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公开(公告)号：US11046764B2
公开(公告)日：2021-06-29
申请号：US15861410
申请日：2018-01-03
Applicant: Trellis Bioscience, LLC
Inventor： Angeles Estelles , Mikhail Gishizky , Stefan Ryser , Lawrence M. Kauvar
Abstract: Novel monoclonal antibodies directed against immune checkpoint modulator (ICM) proteins TIM-3 and B7-H3 are useful in treating cancer and immune system disorders.
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公开(公告)号：US10570193B2
公开(公告)日：2020-02-25
申请号：US16181260
申请日：2018-11-05
Applicant: Trellis Bioscience, LLC
Inventor： Lawrence M. Kauvar , Stefan Ryser , Angeles Estelles , Reyna J. Simon , Lauren Opremcak Bakaletz , Steven David Goodman
IPC: A01N63/00 , A61K48/00 , A61K39/395 , C07K16/12 , A61K39/40 , A01N63/02 , A61K45/06 , A61K49/00 , C07K14/31 , G01N33/569 , C12Q1/18 , G01N33/566 , A61K39/00 , C12N15/86 , A61K35/12
Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
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9.发明授权公开(公告)号：US10858431B2
公开(公告)日：2020-12-08
申请号：US15619327
申请日：2017-06-09
Applicant: Trellis Bioscience, LLC
Inventor： Angeles Estelles , Mikhail Gishizky , Stefan Ryser , Lawrence M. Kauvar
IPC: C07K16/00 , C12P21/08 , C07K16/28 , A61K39/395 , A61K45/06
Abstract: Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
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10.发明申请公开(公告)号：US20200054749A1
公开(公告)日：2020-02-20
申请号：US16674149
申请日：2019-11-05
Applicant: CONTRAFECT CORPORATION , TRELLIS BIOSCIENCE, LLC
Inventor： Angeles Estelles , Lawrence M. Kauvar , Adam Vigil , Michael Wittekind
Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that hind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
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