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    METHOD OF TREATING AND PREVENTING BONE AND JOINT INFECTIONS
    5.
    发明申请
    METHOD OF TREATING AND PREVENTING BONE AND JOINT INFECTIONS 有权

    公开(公告)号：US20220193186A1

    公开(公告)日：2022-06-23

    申请号：US17602064

    申请日：2020-04-10

    Applicant: CONTRAFECT CORPORATION

    Inventor： Raymond SCHUCH

    IPC: A61K38/12 ,  A61K38/47 ,  A61K45/06 ,  A61P19/02 ,  A61P19/08

    Abstract: The present disclosure is directed to a method of treating or preventing a bone or joint infection, which method comprises: administering a therapeutically effective amount of a PlySs2 lysin comprising the amino acid sequence of SEQ ID NO: 1 or a variant thereof having at least 80% identity to SEQ ID NO: 1, wherein the variant comprises bacteriocidal and/or bacteriostatic activity against the Gram-positive bacteria, to a subject in need thereof, optionally co-administered with one or more antibiotics, wherein the bone or joint infection comprises a Gram-positive bacteria, such as Staphylococcus epidermidis or Staphylococcus aureus. Methods for preventing or disrupting a Gram-positive bacterial biofilm formed in a synovial fluid, such as a biofilm formed by Staphylococcus epidermidis, are also disclosed.

    LYSIN-ANTIMICROBIAL PEPTIDE (AMP) POLYPEPTIDE CONSTRUCTS, LYSINS, ISOLATED POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF
    7.
    发明申请
    LYSIN-ANTIMICROBIAL PEPTIDE (AMP) POLYPEPTIDE CONSTRUCTS, LYSINS, ISOLATED POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF 有权

    公开(公告)号：US20220411473A1

    公开(公告)日：2022-12-29

    申请号：US17776375

    申请日：2020-11-13

    Applicant: CONTRAFECT CORPORATION

    Inventor： Raymond SCHUCH

    IPC: C07K14/005 ,  C12N9/36 ,  A61P31/04

    Abstract: The present disclosure is directed to lysin-AMP polypeptide constructs, isolated lysin polypeptides, and pharmaceutical compositions comprising the isolated polypeptides and/or lysin-AMP polypeptide constructs. Methods of using the lysin-AMP polypeptide constructs, isolated lysin polypeptides and pharmaceutical compositions are also herein provided, including methods of treating a bacterial infection of an organ or tissue in which pulmonary surfactant is present or Gram-negative bacterial infections that are associated with a biofilm. In addition, isolated polynucleotides encoding the lysin-AMP polypeptide constructs and isolated lysin polypeptides are disclosed herein.

    MODIFIED PlySs2 LYSINS AND USES THEREOF
    10.
    发明申请
    MODIFIED PlySs2 LYSINS AND USES THEREOF 有权

    公开(公告)号：US20210032294A1

    公开(公告)日：2021-02-04

    申请号：US16975321

    申请日：2019-02-26

    Applicant: CONTRAFECT CORPORATION

    Inventor： Raymond SCHUCH ,  Chiara INDIANI ,  Michael WITTEKIND

    IPC: C07K14/005 ,  C12N9/36 ,  A61P31/04

    Abstract: Disclosed herein are modified lysin polypeptides thereof comprising at least one amino acid substitution as compared to a wild-type PlySs2 lysin polypeptide having an amino acid sequence of SEQ ID NO: 1, wherein the at least one amino acid substitution is in the CHAP domain and/or the SH3b domain, and wherein the modified lysin polypeptide or fragment thereof inhibits the growth, tin reduces the population, or kills at least one species of Gram-positive bacteria. Further disclosed herein are compositions comprising the modified lysin polypeptides, as well as vectors comprising a nucleic acid molecule that encodes the modified lysin polypeptide. Also disclosed herein are methods of inhibiting the growth, reducing the population, or killing at least one species of Gram-positive bacteria, methods of treating a bacterial infection, and methods of augmenting the efficacy of an antibiotic or reducing the development of antibiotic resistance.

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