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公开(公告)号：US10851401B2
公开(公告)日：2020-12-01
申请号：US16096746
申请日：2017-05-12
Applicant: ContraFect Corporation
Inventor： Raymond Schuch
Abstract: The present invention provides components, assays and methods for evaluating antibacterial effectiveness and determining minimal inhibitory concentration (MIC) of polypeptides, including lysin polypeptides, that kill bacteria. Modified broth microdilution components and methods are provided, including supplements to enable accurate MIC determination mimicking lysin polypeptide activity in human matrices including serum and blood.
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2.发明申请公开(公告)号：US20150111813A1
公开(公告)日：2015-04-23
申请号：US14399588
申请日：2013-05-09
Applicant: CONTRAFECT CORPORATION
Inventor： Raymond Schuch , Robert C. Nowinski , Michael Wittekind , Babar Khan , Jimmy Rotolo
IPC: C07K14/315 , A61L29/08 , A01N63/00 , A61L29/16 , A61K38/16
CPC classification number: A01N63/00 , A61K38/16 , A61K38/164 , A61K38/47 , A61K45/06 , A61L29/08 , A61L29/16 , A61L2300/404 , A61L2300/406 , A61L2420/00 , C07K14/315 , C12N9/503 , C12Y302/01017
Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.
Abstract translation: 本发明提供了用赖素，特别是具有杀死葡萄球菌细菌（包括耐药性金黄色葡萄球菌，特别是赖氨酸PlySs2）的能力的赖氨酸来预防，控制，破坏和治疗细菌生物膜的方法。 本发明还提供了用于治疗或调节细菌生物膜和生物膜形成的组合物和方法。
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3.发明申请BACTERIOPHAGE LYSIN AND ANTIBIOTIC COMBINATIONS AGAINST GRAM POSITIVE BACTERIA 审中-公开BACTERIOPHAGE LYSIN和抗生素组合对抗真菌细菌公开(公告)号：US20150290299A1
公开(公告)日：2015-10-15
申请号：US14399575
申请日：2013-05-09
Applicant: CONTRAFECT CORPORATION
Inventor： Raymond Schuch , Robert C. Nowinski , Michael Wittekind , Han Lee , Brent Schneider
IPC: A61K38/47 , A61K45/06 , A61K31/5377 , A61K38/12 , A61K31/4188
Abstract: The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).
Abstract translation: 本发明提供用于预防，改善和治疗革兰氏阳性细菌，特别是葡萄球菌的组合物和溶解素，特别是链球菌赖氨酸，特别是赖氨酸PlySs2和一种或多种抗生素，包括达托霉素，万古霉素，苯唑西林，利奈唑胺 ，或相关的抗生素。
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4.发明公开公开(公告)号：US20240018192A1
公开(公告)日：2024-01-18
申请号：US18452038
申请日：2023-08-18
Applicant: CONTRAFECT CORPORATION
Inventor： Raymond Schuch
CPC classification number: C07K14/005 , A61P31/04 , A61K38/162 , A61K38/1709 , A61K45/06 , C07K14/47 , C12N2795/00022
Abstract: The present disclosure is directed to lysin-AMP polypeptide constructs, isolated lysin polypeptides, and pharmaceutical compositions comprising the isolated polypeptides and/or lysin-AMP polypeptide constructs. Methods of using the lysin-AMP polypeptide constructs, isolated lysin polypeptides and pharmaceutical compositions are also herein provided. In addition, isolated polynucleotides encoding the lysin-AMP polypeptide constructs and isolated lysin polypeptides are disclosed herein.
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公开(公告)号：US11773140B2
公开(公告)日：2023-10-03
申请号：US17041691
申请日：2019-03-29
Applicant: CONTRAFECT CORPORATION
Inventor： Raymond Schuch
CPC classification number: C07K14/005 , A61K38/162 , A61K38/1709 , A61K45/06 , A61P31/04 , C07K14/47 , C12N2795/00022
Abstract: The present disclosure is directed to lysin-AMP polypeptide constructs, isolated lysin polypeptides, and pharmaceutical compositions comprising the isolated polypeptides and/or lysin-AMP polypeptide constructs. Methods of using the lysin-AMP polypeptide constructs, isolated lysin polypeptides and pharmaceutical compositions are also herein provided. In addition, isolated polynucleotides encoding the lysin-AMP polypeptide constructs and isolated lysin polypeptides are disclosed herein.
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Patent Agency Ranking
公开(公告)号：US11524046B2
公开(公告)日：2022-12-13
申请号：US16391272
申请日：2019-04-22
Applicant: ContraFect Corporation
Inventor： Raymond Schuch , Robert C. Nowinski , Michael Wittekind , Babar Khan , Jimmy Rotolo
Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.
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公开(公告)号：US11413334B2
公开(公告)日：2022-08-16
申请号：US16924681
申请日：2020-07-09
Applicant: CONTRAFECT CORPORATION
Inventor： Raymond Schuch , Simon Hoffenberg , Michael Wittekind
IPC: A61K38/47 , A61K38/12 , A61K45/06 , A61K9/00 , A61K31/7036 , A61K38/46 , A61K38/16 , A61P31/04 , C12N9/36
Abstract: The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. The disclosure further provides compositions and methods of incorporating and utilizing lysin polypeptides of the present disclosure for augmenting the efficacy of antibiotics generally suitable for the treatment of Gram-negative bacterial infection.
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公开(公告)号：US12121568B2
公开(公告)日：2024-10-22
申请号：US16772001
申请日：2018-12-12
Applicant: CONTRAFECT CORPORATION
Inventor： Raymond Schuch , Chiara Indiani
CPC classification number: A61K38/47 , A61K45/06 , A61P31/04 , C12N9/2462 , C12Y302/01017
Abstract: Disclosed are novel lysin polypeptides active against Gram-negative bacteria, particularly P. aeruginosa, pharmaceutical compositions containing them and methods for their use to treat Gram-negative bacterial infections and more generally to inhibit the growth, or reduce the population, or kill Gram-negative bacteria, including without limitation disrupting biofilms formed by such bacteria. Certain of the disclosed lysins have been modified in amino acid sequence compared to that of lysins by replacement of certain charged amino acids with noncharged amino acids and/or by fusion at the N- or C-terminus with antibacterial peptide sequences with or without an intervening linker.
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公开(公告)号：US10988520B2
公开(公告)日：2021-04-27
申请号：US16777154
申请日：2020-01-30
Applicant: ContraFect Corporation
Inventor： Raymond Schuch
Abstract: The present disclosure is directed to a lysin-AMP polypeptide construct comprising: (a) a first component comprising the polypeptide sequence of: (i) SEQ ID NO: 118 (GN202); or (ii) a polypeptide having lysin activity and having at least 80% sequence identity with the polypeptide sequence of SEQ ID NO: 118 (GN202); or (iii) an active fragment of SEQ ID NO: 118 (GN202); and (b) a second component comprising the polypeptide sequence of at least one antimicrobial peptide (AMP), wherein the at least one AMP comprises SEQ ID NO: 114 (FIRL). Exemplary lysin-AMP polypeptides, such as GN370 (SEQ ID NO: 44) as well as methods of treating bacterial infections using the present lysin-AMP polypeptide constructs are also disclosed.
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公开(公告)号：US10813983B2
公开(公告)日：2020-10-27
申请号：US14399575
申请日：2013-05-09
Applicant: CONTRAFECT CORPORATION
Inventor： Raymond Schuch , Robert C. Nowinski , Michael Wittekind , Han Lee , Brent Schneider
IPC: A61K38/46 , C12N9/50 , A61K31/4188 , A61K31/5377 , A61K38/12 , A61K38/47 , A61K45/06 , A61K38/14
Abstract: The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).
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