公开(公告)号：US09688744B2

公开(公告)日：2017-06-27

申请号：US14697459

申请日：2015-04-27

Applicant: Trellis Bioscience, LLC

Inventor： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

IPC: A61K39/395 ,  C07K16/08 ,  C07K16/46 ,  A61K39/245 ,  A61K39/00

CPC classification number: C07K16/088 ,  A61K39/245 ,  A61K2039/505 ,  C07K16/08 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

公开(公告)号：US10030069B2

公开(公告)日：2018-07-24

申请号：US15464165

申请日：2017-03-20

Applicant: Trellis Bioscience, LLC ,  Laurie M. Usinger

Inventor： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

IPC: C07K16/08 ,  C07K16/46 ,  A61K39/245 ,  A61K39/00

Abstract: Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

公开(公告)号：US10654915B2

公开(公告)日：2020-05-19

申请号：US14363297

申请日：2012-12-05

Applicant: Trellis Bioscience, LLC

Inventor： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Minha Park

IPC: C07K16/10 ,  A61K39/00

Abstract: Specific monoclonal antibodies and fragments including bispecific antibodies thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.

公开(公告)号：US20140322210A1

公开(公告)日：2014-10-30

申请号：US14363297

申请日：2012-12-05

Applicant: Trellis Bioscience, LLC

Inventor： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Minha Park

IPC: C07K16/10

CPC classification number: C07K16/1018 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: Specific monoclonal antibodies and fragments including bispecific antibodies thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.

Abstract translation: 公开了与包括第1组和第2组代表的流感病毒的多个进化枝交叉反应的特异性单克隆抗体和包括其双特异性抗体的片段。 这些抗体可用于控制流行性感冒和大流行以及为季节性流感提供预防或治疗保护。