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公开(公告)号：US20060246512A1
公开(公告)日：2006-11-02
申请号：US11377554
申请日：2006-03-17
Applicant: Toshihide Ezoe , Taisei Nishimi , Yukou Saito
Inventor： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
CPC classification number: C12Q1/002 , G01N21/553 , G01N21/554 , G01N33/5438 , Y10S436/805
Abstract: It is an object of the present invention to provide a biosensor, wherein non-specific adsorption on a surface that does not retain a physiologically active substance (reference unit) is suppressed. The present invention provides a biosensor which comprises a substrate having at least two types of surfaces on a single plane, wherein at least one of said surfaces does not retain a physiologically active substance, and wherein at least two types of hydrophilic compounds with different molecular weights are bound to said surface that does not retain a physiologically active substance.
Abstract translation: 本发明的目的是提供一种生物传感器，其中抑制了不保留生理活性物质（参考单元）的表面上的非特异性吸附。 本发明提供了一种生物传感器，其包括在单个平面上具有至少两种类型的表面的基底，其中所述表面中的至少一个不保留生理活性物质，并且其中至少两种具有不同分子量的亲水性化合物 结合到不保留生理活性物质的所述表面。
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公开(公告)号：US07964414B2
公开(公告)日：2011-06-21
申请号：US11377554
申请日：2006-03-17
Applicant: Toshihide Ezoe , Taisei Nishimi , Yukou Saito
Inventor： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
IPC: G01N33/543 , C12M1/34
CPC classification number: C12Q1/002 , G01N21/553 , G01N21/554 , G01N33/5438 , Y10S436/805
Abstract: The present invention provides a biosensor, wherein non-specific adsorption on a surface that does not retain a physiologically active substance (reference unit) is suppressed. The biosensor of the invention includes a substrate having at least two types of surfaces on a single plane, wherein at least one of the surfaces does not retain a physiologically active substance, and wherein at least two types of hydrophilic compounds with different molecular weights are bound to the surface that does not retain a physiologically active substance.
Abstract translation: 本发明提供一种生物传感器，其中抑制了不保留生理活性物质（参考单元）的表面上的非特异性吸附。 本发明的生物传感器包括在单个平面上具有至少两种类型的表面的基底，其中至少一个表面不保留生理活性物质，并且其中至少两种具有不同分子量的亲水性化合物被结合 到没有保留生理活性物质的表面。
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公开(公告)号：US07563623B2
公开(公告)日：2009-07-21
申请号：US11708637
申请日：2007-02-21
Applicant: Toshihide Ezoe , Taisei Nishimi , Yukou Saito
Inventor： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
IPC: G01N33/551
CPC classification number: G01N33/54353 , Y10S435/808 , Y10S436/805
Abstract: It is an object of the present invention to provide a biosensor on which a large amount of protein can be immobilized and nonspecific adsorption is less likely to occur with the use of a SAM compound having high water solubility and good performance in terms of supply. The present invention provides a biosensor comprising a substrate on which a hydrophilic polymer having a reactive group capable of binding to a physiologically active substance is immobilized via a compound represented by the following formula (1), said compound at a concentration of 1 mM being dissolved in water at 25° C.: X-L-Y (1) wherein X represents a group capable of binding to metal, L represents a linking group, and Y represents a functional group to which the hydrophilic polymer is bound.
Abstract translation: 本发明的目的是提供一种生物传感器，其中可以固定大量的蛋白质，并且通过使用具有高水溶性的SAM化合物和在供给方面的良好性能，不太可能发生非特异性吸附。 本发明提供了一种生物传感器，其包括通过下式（1）表示的化合物固定具有能够结合生理活性物质的反应性基团的亲水性聚合物的基材，所述化合物浓度为1mM时溶解 在25°C的水中：<？in-line-formula description =“In-line Formulas”end =“lead”？> XLY（1）<？in-line-formula description =“In-line Formulas”end =“尾”→其中X表示能够与金属结合的基团，L表示连接基团，Y表示亲水性聚合物结合的官能团。
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公开(公告)号：US20080038841A1
公开(公告)日：2008-02-14
申请号：US11708637
申请日：2007-02-21
Applicant: Toshihide Ezoe , Taisei Nishimi , Yukou Saito
Inventor： Toshihide Ezoe , Taisei Nishimi , Yukou Saito
CPC classification number: G01N33/54353 , Y10S435/808 , Y10S436/805
Abstract: It is an object of the present invention to provide a biosensor on which a large amount of protein can be immobilized and nonspecific adsorption is less likely to occur with the use of a SAM compound having high water solubility and good performance in terms of supply. The present invention provides a biosensor comprising a substrate on which a hydrophilic polymer having a reactive group capable of binding to a physiologically active substance is immobilized via a compound represented by the following formula (1), said compound at a concentration of 1 mM being dissolved in water at 25° C.: X-L-Y (1) wherein X represents a group capable of binding to metal, L represents a linking group, and Y represents a functional group to which the hydrophilic polymer is bound.
Abstract translation: 本发明的目的是提供一种生物传感器，其中可以固定大量的蛋白质，并且通过使用具有高水溶性的SAM化合物和在供给方面的良好性能，不太可能发生非特异性吸附。 本发明提供了一种生物传感器，其包括通过下式（1）表示的化合物固定具有能够结合生理活性物质的反应性基团的亲水性聚合物的基材，所述化合物浓度为1mM时溶解 在25°C的水中：<？in-line-formula description =“In-line Formulas”end =“lead”？> XLY（1）<？in-line-formula description =“In-line Formulas”end =“尾”→其中X表示能够与金属结合的基团，L表示连接基团，Y表示亲水性聚合物结合的官能团。
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Patent Agency Ranking
公开(公告)号：US20070040244A1
公开(公告)日：2007-02-22
申请号：US11504078
申请日：2006-08-15
Applicant: Yukou Saito , Hirohiko Tsuzuki , Toshiaki Kubo
Inventor： Yukou Saito , Hirohiko Tsuzuki , Toshiaki Kubo
IPC: H01L23/58
Abstract: It is an object of the present invention to provide a substrate for sensors and a container, wherein the adhesiveness of the substrate to a thin film is improved, a physiologically active substance can be immobilized without the peeling of the thin film from a plastic substrate, and non-specific adsorption during the analysis of interaction among biomolecules is small. The present invention provides a substrate for sensors, which has a thin film layer on a plastic substrate, wherein the plastic substrate has been treated with an organic primer before formation of the thin film.
Abstract translation: 本发明的目的是提供一种用于传感器和容器的基板，其中基板与薄膜的粘合性得到改善，可以固定生理活性物质，而不会从塑料基板剥离薄膜， 在生物分子相互作用分析过程中的非特异性吸附量较小。 本发明提供了一种用于传感器的基板，其在塑料基板上具有薄膜层，其中塑料基板已经在形成薄膜之前用有机底漆处理。
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公开(公告)号：US20050181497A1
公开(公告)日：2005-08-18
申请号：US11003445
申请日：2004-12-06
Applicant: Yukou Saito , Hirohiko Tsuzuki
Inventor： Yukou Saito , Hirohiko Tsuzuki
IPC: C12M1/34 , G01N21/55 , G01N33/543
CPC classification number: G01N33/54353 , G01N21/553
Abstract: It is an object of the present invention to provide a solid substrate used for sensors that suppresses nonspecific adsorption and that is able to immobilize a physiologically active substance. The present invention provides A solid substrate used for sensors, wherein two or more different hydrophobic polymer layers are laminated on the solid substrate, and among the above hydrophobic polymer layers, the surface of a layer, which is farthest from the solid substrate, is modified.
Abstract translation: 本发明的目的是提供用于抑制非特异性吸附的传感器的固体基质，并且能够固定生理活性物质。 本发明提供一种用于传感器的固体基板，其中在固体基板上层压两个或更多个不同的疏水性聚合物层，并且在上述疏水性聚合物层中，与固体基板最远的层的表面被改性 。
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公开(公告)号：US07740908B2
公开(公告)日：2010-06-22
申请号：US11362741
申请日：2006-02-28
Applicant: Yukou Saito , Masashi Hakamata
Inventor： Yukou Saito , Masashi Hakamata
CPC classification number: G01N21/553 , Y10T428/31511 , Y10T428/31692 , Y10T428/31855
Abstract: It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a method for producing a solid substrate for sensors that has a coating on the surface using spin coating, wherein a substrate to be coated is rotated in an atmosphere in which the vapor pressure of coating solvent is 50% to 100% with respect to the saturation vapor pressure so as to form a thin film of a coating solution on said substrate to be coated.
Abstract translation: 本发明的目的是提供一种用于制造具有薄膜厚度分布薄膜的传感器的固体基板的制造方法，以及用于具有薄膜厚度分布薄膜的传感器的固体表面。 本发明提供了一种用于制造传感器的固体基板的方法，该传感器在旋转涂层的表面上具有涂层，其中待涂布的基材在涂布溶剂的蒸气压为50％至100％的气氛中旋转， 相对于饱和蒸气压，以便在待涂覆的基底上形成涂层溶液的薄膜。
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公开(公告)号：US20060073521A1
公开(公告)日：2006-04-06
申请号：US11238013
申请日：2005-09-29
Applicant: Yukou Saito , Hirohiko Tsuzuki
Inventor： Yukou Saito , Hirohiko Tsuzuki
CPC classification number: C03C17/38 , B05D1/005 , C03C2218/116
Abstract: It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a method for spin coating wherein the substrate is rotated in a state where the substrate surface to be coated is inclined against the rotation surface during coating.
Abstract translation: 本发明的目的是提供一种用于制造具有薄膜厚度分布薄膜的传感器的固体基板的制造方法，以及用于具有薄膜厚度分布薄膜的传感器的固体表面。 本发明提供了一种旋涂方法，其中基材在被涂覆的基材表面在涂布期间相对于旋转表面倾斜的状态下旋转。
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公开(公告)号：US20070259193A1
公开(公告)日：2007-11-08
申请号：US11362741
申请日：2006-02-28
Applicant: Yukou Saito , Masashi Hakamata
Inventor： Yukou Saito , Masashi Hakamata
IPC: B05D3/12
CPC classification number: G01N21/553 , Y10T428/31511 , Y10T428/31692 , Y10T428/31855
Abstract: It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a method for producing a solid substrate for sensors that has a coating on the surface using spin coating, wherein a substrate to be coated is rotated in an atmosphere in which the vapor pressure of coating solvent is 50% to 100% with respect to the saturation vapor pressure so as to form a thin film of a coating solution on said substrate to be coated.
Abstract translation: 本发明的目的是提供一种用于制造具有薄膜厚度分布薄膜的传感器的固体基板的制造方法，以及用于具有薄膜厚度分布薄膜的传感器的固体表面。 本发明提供了一种用于制造传感器的固体基板的方法，该传感器在旋转涂层的表面上具有涂层，其中待涂布的基材在涂布溶剂的蒸气压为50％至100％的气氛中旋转， 相对于饱和蒸气压，以便在待涂覆的基底上形成涂层溶液的薄膜。
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