公开(公告)号：US4628743A

公开(公告)日：1986-12-16

申请号：US738125

申请日：1985-06-14

Applicant: Theodore E. Miller, Jr. ,  Hamish Small

Inventor： Theodore E. Miller, Jr. ,  Hamish Small

IPC: G01F1/704 ,  G01F11/00 ,  G01F11/28 ,  G01F13/00 ,  G01F1/68 ,  G01F1/70 ,  G01P5/18

CPC classification number: G01F11/00 ,  G01F1/7044 ,  G01F11/28 ,  G01F13/00

Abstract: Apparatus for accurately metering liquid flow based on the injection of a brief heat pulse into the flowing stream, e.g., via a miniature thermistor, and detection of an electronic time derivative of temperature downstream with, e.g., a second microprobe thermistor. This detection triggers a subsequent heat pulse and the cycle repeats, with pulse total corresponding to elapsed liquid throughput, and pulse frequency to flow rate.

Abstract translation: 基于将短暂的热脉冲注入到流动流中，例如通过微型热敏电阻，以及利用例如第二微孔热敏电阻检测下游温度的电子时间导数的装置。 该检测触发随后的加热脉冲，循环重复，脉冲总数对应于经过的液体通过量，脉冲频率与流速。

公开(公告)号：US4414842A

公开(公告)日：1983-11-15

申请号：US364705

申请日：1982-04-02

Applicant: Hamish Small ,  Theodore E. Miller, Jr.

Inventor： Hamish Small ,  Theodore E. Miller, Jr.

IPC: G01N30/02 ,  G01N30/96 ,  G01N21/00

CPC classification number: G01N30/96 ,  G01N30/02

Abstract: An improved technique for the measurement of ions in solution where the ions of interest are chromatographically displaced from an ion exchange column by an eluting ion which is or is made light-absorbing, and where the eluted sample ions, which are transparent (at the monitored wavelength), are detected and quantified from the decrements they cause in effluent absorbance as revealed by photometric monitoring.

Abstract translation: 用于测量溶液中离子的改进技术，其中感兴趣的离子通过被吸收或被吸收的洗脱离子从离子交换柱色谱位移，并且其中被洗涤的样品离子是透明的 波长），由其通过光度监测显示的流出物吸光度引起的减量进行检测和量化。

公开(公告)号：US4532811A

公开(公告)日：1985-08-06

申请号：US280668

申请日：1981-07-06

Applicant: Theodore E. Miller, Jr. ,  Hamish Small

Inventor： Theodore E. Miller, Jr. ,  Hamish Small

IPC: G01F11/00 ,  G01F11/28 ,  G01F13/00 ,  G01F1/68

CPC classification number: G01F11/00 ,  G01F11/28 ,  G01F13/00

Abstract: Apparatus for accurately metering liquid flow based on the injection of a brief heat pulse into the flowing stream, e.g., via a miniature thermistor, and detection of an electronic time derivative of temperature downstream with, e.g., a second microprobe thermistor. This detection triggers a subsequent heat pulse and the cycle repeats, wth pulse total corresponding to elapsed liquid throughput, and pulse frequency to flow rate.

Abstract translation: 基于将短暂的热脉冲注入到流动流中，例如通过微型热敏电阻，以及利用例如第二微孔热敏电阻检测下游温度的电子时间导数的装置。 该检测触发随后的加热脉冲，循环重复，对应于经过的液体吞吐量，脉冲频率与流量的第w个脉冲总数。

公开(公告)号：US06316271B1

公开(公告)日：2001-11-13

申请号：US09470833

申请日：1999-12-23

Applicant: Hamish Small ,  Nebojsa Avdalovic ,  Yan Liu

Inventor： Hamish Small ,  Nebojsa Avdalovic ,  Yan Liu

IPC: G01N3116

CPC classification number: B01J39/26 ,  B01J47/08 ,  G01N30/02 ,  G01N30/34 ,  G01N2030/407 ,  G01N2030/965 ,  Y10T436/117497 ,  B01D15/362

Abstract: A method for generating high purity acid or base in an aqueous stream for use in analysis. For generating a base for anion chromatography, the aqueous stream is directed through a cation exchange bed having strongly acid first and weakly acidic second portions. An electrical potential is applied to the bed. Cations on the bed electromigrate into the aqueous stream while hydroxide ions are electrolytically generated to form a base-containing eluent. Analytes to be detected and the generated eluent flow through a detector.

Abstract translation: 一种在含水流中产生高纯度酸或碱的方法，用于分析。 为了产生用于阴离子色谱法的碱，水流通过具有强酸性第一和弱酸性第二部分的阳离子交换床。 电位施加到床上。 床上的阳离子电迁移到水流中，同时电解产生氢氧根离子以形成含碱的洗脱液。 待检测的分析物和产生的洗脱液流过检测器。

公开(公告)号：US5773615A

公开(公告)日：1998-06-30

申请号：US600856

申请日：1996-02-13

Applicant: Hamish Small ,  John M. Riviello ,  Steven B. Rabin

Inventor： Hamish Small ,  John M. Riviello ,  Steven B. Rabin

IPC: G01N30/02 ,  G01N30/60 ,  G01N30/96

CPC classification number: G01N30/96 ,  G01N2030/965 ,  Y10T436/25125

Abstract: Method and apparatus for ion chromatography including passage of sample through a chromatographic separation column, through a suppressor column containing a resin with exchangeable ions, and then through a detector. The suppressor column is equipped with an electrical potential supplying device to electrolyze water and regenerate the suppressor column.

Abstract translation: 用于离子色谱法的方法和装置，包括样品通过色谱分离柱，通过含有可交换离子的树脂的抑制柱，然后通过检测器。 抑制柱配备有电解水并且再生抑制柱的电位供给装置。

公开(公告)号：US5597734A

公开(公告)日：1997-01-28

申请号：US503999

申请日：1995-07-19

Applicant: Hamish Small ,  John Riviello ,  Christopher A. Pohl

Inventor： Hamish Small ,  John Riviello ,  Christopher A. Pohl

IPC: A61B17/60 ,  A61B17/64 ,  G01N30/02 ,  G01N30/60 ,  G01N30/96

CPC classification number: G01N30/96 ,  G01N2030/965

Abstract: An ion chromatography method for analysis of a plurality of analyte ions in a sequence of samples in which ion chromatography is performed on a sample, which is passed to a non-precipitating suppressor ion exchange resin and analyzed, the suppressor being regenerated in one step prior to processing of a subsequent sample.

Abstract translation: 一种用于分析样品序列中的多个分析物离子的离子色谱法，其中对样品进行离子色谱，所述样品被传递到非沉淀抑制离子交换树脂，并分析了在一个步骤中再生的抑制剂 以处理随后的样品。

公开(公告)号：US4732686A

公开(公告)日：1988-03-22

申请号：US811144

申请日：1985-12-19

Applicant: Hamish Small ,  Mark E. Soderquist ,  James W. Pischke

Inventor： Hamish Small ,  Mark E. Soderquist ,  James W. Pischke

IPC: G01N30/96 ,  B01D15/08

CPC classification number: G01N30/96

Abstract: Apparatus and method for the chromatographic separation and analysis of ionic species. This process is carried out utilizing, in an ion separator column, the combination of a low capacity, high performance resin as the stationary phase, and a weakly ionized electrolyte as the eluant or developing reagent, to effect resolution of ionic species in solution. For anion separation, a weak base resin of low capacity and high efficiency is used as the stationary phase, and a solution of a weak base or water as the mobile phase. For cation separation, a weak acid resin of low capacity and high efficiency is used as the stationary phase and a solution of a weak acid as the mobile phase. Because the eluant employed has a very low background conductivity, it will register only insignificantly on the readout from the conductivity cell. Thus, the method of the invention obviates the need for the eluant suppressor or "stripper" device used in conventional ion chromatography. The invention thereby enables continuous, uninterrupted measurements and eliminates the reservoirs, pumps, complex valving and electronics associated with such suppressor columns.

Abstract translation: 离子物质色谱分离和分析的仪器和方法。 该方法在离子分离塔中利用作为固定相的低容量高性能树脂和作为洗脱剂或显色剂的弱离子化电解质的组合来实现溶液中离子物质的分离。 对于阴离子分离，使用低容量和高效率的弱碱性树脂作为固定相，将弱碱或水作为流动相的溶液。 对于阳离子分离，使用低容量和高效率的弱酸性树脂作为固定相和弱酸作为流动相的溶液。 因为所使用的洗脱液具有非常低的背景电导率，所以它将仅在电导率电池的读数上不重要地注册。 因此，本发明的方法消除了在常规离子色谱法中使用的洗脱液抑制剂或“汽提器”装置的需要。 因此，本发明能够进行连续的，不间断的测量并且消除与这种抑制器柱相关联的储存器，泵，复杂阀门和电子装置。

公开(公告)号：US08367423B2

公开(公告)日：2013-02-05

申请号：US12706944

申请日：2010-02-17

Applicant: Yan Liu ,  Hamish Small ,  Nebojsa Avdalovic

Inventor： Yan Liu ,  Hamish Small ,  Nebojsa Avdalovic

IPC: G01N30/28

CPC classification number: G01N30/96 ,  C25B1/16 ,  C25B1/22 ,  G01N30/02 ,  G01N30/34 ,  G01N2030/965 ,  Y10T436/25 ,  B01D15/36 ,  B01D15/426

Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.

Abstract translation: 用于产生酸或碱的方法和设备，例如， 用于阴离子的色谱分析。 为了产生碱，该方法包括以下步骤：在阳离子源储存器中提供阳离子源，使水性液体流通过基本上防止液体流动的屏障（例如带电膜）与阳离子源储存器分离的碱性产生室流动， 提供阳离子输送桥，在基底产生室中的阳极阳离子源储存器和阴极之间施加电位以在其中电解产生氢氧根离子，并使阳离子源储存器中的阳离子电迁移并穿过屏障向着 阴极与所运送的阳离子结合以形成阳离子氢氧化物，并且以水溶液流中的阳离子氢氧化物作为来自第一碱基产生室的流出物除去。 合适的阳离子源包括盐溶液，阳离子氢氧化物溶液或阳离子交换树脂。

公开(公告)号：US20100038245A1

公开(公告)日：2010-02-18

申请号：US12192781

申请日：2008-08-15

Applicant: Hamish Small ,  Yan Liu ,  Christopher A. Pohl

Inventor： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

IPC: B01D59/42

CPC classification number: G01N30/96 ,  B01D61/427 ,  F04B17/00 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095

Abstract: A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, a first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.

Abstract translation: 一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发生器室与阳极室分开，与阳极室电连通的第一电极，邻近的阴极室 所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。 使用泵作为样品浓缩器。 泵的反馈回路。 在泵的输出侧具有或不具有中间活塞的储存器。

公开(公告)号：US06682701B1

公开(公告)日：2004-01-27

申请号：US09612074

申请日：2000-07-07

Applicant: Yan Liu ,  Hamish Small ,  Nebojsa Avdalovic

Inventor： Yan Liu ,  Hamish Small ,  Nebojsa Avdalovic

IPC: G01N3002

CPC classification number: G01N30/96 ,  C25B1/16 ,  C25B1/22 ,  G01N30/02 ,  G01N30/34 ,  G01N2030/965 ,  Y10T436/25 ,  B01D15/36 ,  B01D15/426

Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.

Abstract translation: 用于产生酸或碱的方法和设备，例如， 用于阴离子的色谱分析。 为了产生碱，该方法包括以下步骤：在阳离子源储存器中提供阳离子源，使水性液体流通过基本上防止液体流动的屏障（例如带电膜）与阳离子源储存器分离的碱性产生室流动， 提供阳离子输送桥，在基底产生室中的阳极阳离子源储存器和阴极之间施加电位以在其中电解产生氢氧根离子，并使阳离子源储存器中的阳离子电迁移并穿过屏障向着 阴极与所运送的阳离子结合以形成阳离子氢氧化物，并且以水溶液流中的阳离子氢氧化物作为来自第一碱基产生室的流出物除去。 合适的阳离子源包括盐溶液，阳离子氢氧化物溶液或阳离子交换树脂。