公开(公告)号：US20160193363A1

公开(公告)日：2016-07-07

申请号：US14916779

申请日：2014-09-04

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Chongzhao Ran ,  Anna Moore ,  Anna-Liisa Brownell

IPC: A61K49/00 ,  A61K49/22 ,  A61K51/04 ,  A61K49/06

CPC classification number: A61K49/0002 ,  A61K49/0017 ,  A61K49/06 ,  A61K49/22 ,  A61K51/04 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04

Abstract: Methods and compositions for imaging Brown adipose tissue (BAT) in living mammals, e.g., humans.

Abstract translation: 用于在活体哺乳动物（例如人）中成像棕色脂肪组织（BAT）的方法和组合物。

公开(公告)号：US20230346984A1

公开(公告)日：2023-11-02

申请号：US17796464

申请日：2021-01-29

Applicant: The General Hospital Corporation

Inventor： Chongzhao Ran ,  Jing Yang ,  Wei Yin ,  Biyue Zhu ,  Fan Yang

IPC: A61K49/00 ,  G01N33/68 ,  A61B5/00

CPC classification number: A61K49/0021 ,  G01N33/6896 ,  A61B5/0071 ,  A61K49/0052 ,  G01N2800/2814

Abstract: The present application provides a compound of Formula (I): A-L-B (I), or a pharmaceutically acceptable salt thereof, wherein A, L, and B are as described herein. Compositions comprising the compounds of Formula (I) (and optionally a fluorescent probe) are also provided, as well as the methods of (i) using the compound of formula (I) for identifying a misfolding-prone or an aggregating-prone protein in a sample, (ii) determining concentration of a misfolding-prone or an aggregating-prone protein in a sample, (iii) imaging an organ or tissue comprising a misfolding-prone or an aggregating-prone protein in a subject, (iv) diagnosing or monitoring treatment of a disease or condition associated with a misfolding-prone or an aggregating-prone protein in a subject, and (v) diagnosing a disease or condition characterized by accumulation of misfolding-prone or aggregation-prone peptides or proteins in a blood of a subject.

公开(公告)号：US20220001035A1

公开(公告)日：2022-01-06

申请号：US17448463

申请日：2021-09-22

Applicant: The General Hospital Corporation

Inventor： Chongzhao Ran ,  Anna Moore ,  Jian Yang

IPC: A61K51/04 ,  C07B59/00 ,  C07F5/02 ,  C07C49/248 ,  C07C49/252

Abstract: Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.

公开(公告)号：US11135318B2

公开(公告)日：2021-10-05

申请号：US16314153

申请日：2017-06-29

Applicant: The General Hospital Corporation

Inventor： Chongzhao Ran ,  Anna Moore ,  Jian Yang

IPC: A61K51/04 ,  C07F5/02 ,  C07C49/248 ,  A61P25/28 ,  C07B59/00 ,  C07C49/252 ,  A61P25/16

Abstract: Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.

公开(公告)号：US09757477B2

公开(公告)日：2017-09-12

申请号：US14916779

申请日：2014-09-04

Applicant: The General Hospital Corporation

Inventor： Chongzhao Ran ,  Anna Moore ,  Anna-Liisa Brownell

IPC: A61K49/06 ,  A61K51/04 ,  A61K49/00 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  A61K49/22

CPC classification number: A61K49/0002 ,  A61K49/0017 ,  A61K49/06 ,  A61K49/22 ,  A61K51/04 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04

Abstract: Methods and compositions for imaging Brown adipose tissue (BAT) in living mammals, e.g., humans.

公开(公告)号：US09738623B2

公开(公告)日：2017-08-22

申请号：US14419985

申请日：2013-08-06

Applicant: The General Hospital Corporation

Inventor： Chongzhao Ran ,  Xueli Zhang ,  Anna Moore

IPC: C07D403/02 ,  C07D407/02 ,  C07D405/14 ,  C07D401/06 ,  C07C225/16 ,  C07D213/74 ,  C07D213/89 ,  C07D231/12 ,  C07D233/60 ,  C07D471/06 ,  C07D277/64 ,  C07F5/02 ,  C07C49/248 ,  C07C49/252 ,  C07C225/22

CPC classification number: C07D401/06 ,  C07C49/248 ,  C07C49/252 ,  C07C225/16 ,  C07C225/22 ,  C07D213/74 ,  C07D213/89 ,  C07D231/12 ,  C07D233/60 ,  C07D277/64 ,  C07D405/14 ,  C07D471/06 ,  C07F5/022

Abstract: Provided herein are curcumin analogues that are able to interact with amyloid β (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds in the treatment of Alzheimer's Disease or a related disorder.

公开(公告)号：US12138321B2

公开(公告)日：2024-11-12

申请号：US17448463

申请日：2021-09-22

Applicant: The General Hospital Corporation

Inventor： Chongzhao Ran ,  Anna Moore ,  Jian Yang

IPC: A61K51/04 ,  C07B59/00 ,  C07C49/248 ,  C07C49/252 ,  C07F5/02 ,  A61P25/16 ,  A61P25/28

Abstract: Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.

公开(公告)号：US12102695B2

公开(公告)日：2024-10-01

申请号：US17480924

申请日：2021-09-21

Applicant: The General Hospital Corporation

Inventor： Chongzhao Ran ,  Anna Moore ,  Jian Yang

IPC: A61K51/04 ,  A61P25/28 ,  C07B59/00 ,  C07C49/248 ,  C07C49/252 ,  C07F5/02 ,  A61P25/16

CPC classification number: A61K51/0453 ,  A61K51/04 ,  A61K51/0455 ,  C07B59/002 ,  C07C49/248 ,  C07C49/252 ,  C07F5/02 ,  A61K2123/00 ,  A61P25/16 ,  A61P25/28 ,  C07B2200/05 ,  C07F5/022

Abstract: Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.

公开(公告)号：US20220001036A1

公开(公告)日：2022-01-06

申请号：US17480924

申请日：2021-09-21

Applicant: The General Hospital Corporation

Inventor： Chongzhao Ran ,  Anna Moore ,  Jian Yang

IPC: A61K51/04 ,  C07B59/00 ,  C07F5/02 ,  C07C49/248 ,  C07C49/252

Abstract: Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.

公开(公告)号：US10149644B2

公开(公告)日：2018-12-11

申请号：US14515665

申请日：2014-10-16

Applicant: The General Hospital Corporation

Inventor： Chongzhao Ran ,  Anna Moore

IPC: A61K51/00 ,  A61M36/14 ,  A61B5/00 ,  A61K49/00 ,  A61K51/04 ,  G01N33/68 ,  A61B5/145 ,  A61B5/1455 ,  A61B6/03 ,  A61M5/00 ,  G01R33/56

Abstract: The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid β aggregates, these probes undergo a range of changes, qualifying them as “smart” probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid β aggregates and plaques.