公开(公告)号：US10676715B2

公开(公告)日：2020-06-09

申请号：US15938564

申请日：2018-03-28

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Jimena Andersen ,  Fikri Birey ,  Sergiu P. Pasca

IPC分类号： C12N5/079 ,  C12N5/074 ,  C12N5/0797

摘要： Human pluripotent stem cells are differentiated in vitro into forebrain subdomain structures, which are then fused to generate an integrated system for use in analysis, screening programs, and the like.

公开(公告)号：US20200291352A1

公开(公告)日：2020-09-17

申请号：US16884980

申请日：2020-05-27

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Jimena Andersen ,  Fikri Birey ,  Sergiu P. Pasca

IPC分类号： C12N5/079 ,  C12N5/074 ,  C12N5/0797

摘要： Human pluripotent stem cells are differentiated in vitro into forebrain subdomain structures, which are then fused to generate an integrated system for use in analysis, screening programs, and the like.

公开(公告)号：US20180282689A1

公开(公告)日：2018-10-04

申请号：US15938564

申请日：2018-03-28

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Jimena Andersen ,  Fikri Birey ,  Sergiu P. Pasca

IPC分类号： C12N5/079 ,  C12N5/074

摘要： Human pluripotent stem cells are differentiated in vitro into forebrain subdomain structures, which are then fused to generate an integrated system for use in analysis, screening programs, and the like.

公开(公告)号：US12110510B2

公开(公告)日：2024-10-08

申请号：US17253038

申请日：2019-06-20

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Jimena Andersen ,  Sergiu P. Pasca

IPC分类号： C12N5/071 ,  C12N5/077 ,  C12N5/0793 ,  G01N33/50

CPC分类号： C12N5/0697 ,  C12N5/0619 ,  C12N5/0658 ,  G01N33/5082 ,  C12N2500/38 ,  C12N2501/01 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/15 ,  C12N2501/41 ,  C12N2501/734 ,  C12N2501/999 ,  C12N2502/081 ,  C12N2502/1335 ,  C12N2506/45 ,  C12N2513/00

摘要： Functional human cortico-spinal-muscle assembled spheroids are generated by in vitro culture. Complete cortico-spinal-muscle spheroids (hCS-hSC-hSkM) are assembled from component cultured cell systems, where each cultured cell system is designed to provide specific sets of neural and/or muscle cells, and which components are functionally integrated in the assembled spheroid.

公开(公告)号：US11279914B2

公开(公告)日：2022-03-22

申请号：US16884980

申请日：2020-05-27

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Jimena Andersen ,  Fikri Birey ,  Sergiu P. Pasca

IPC分类号： C12N5/0793 ,  C12N5/10 ,  C12N5/00 ,  C12N5/079 ,  C12N5/074 ,  C12N5/0797 ,  G01N33/50

摘要： Human pluripotent stem cells are differentiated in vitro into forebrain subdomain structures, which are then fused to generate an integrated system for use in analysis, screening programs, and the like.

公开(公告)号：US20210261924A1

公开(公告)日：2021-08-26

申请号：US17253038

申请日：2019-06-20

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Jimena Andersen ,  Sergiu P. Pasca

IPC分类号： C12N5/071 ,  C12N5/077 ,  C12N5/0793 ,  G01N33/50

摘要： Functional human cortico-spinal-muscle assembled spheroids are generated by in vitro culture. Complete cortico-spinal-muscle spheroids (hCS-hSC-hSkM) are assembled from component cultured cell systems, where each cultured cell system is designed to provide specific sets of neural and/or muscle cells, and which components are functionally integrated in the assembled spheroid.