公开(公告)号：US11013818B2

公开(公告)日：2021-05-25

申请号：US16114187

申请日：2018-08-27

申请人： The Board of Regents of the University of Texas System

发明人： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC分类号： A61K49/00 ,  C09B69/10 ,  G01N33/84 ,  G01N33/58 ,  G01N21/64 ,  C08F8/42 ,  C08F8/34 ,  C08F8/32 ,  C08F8/30

摘要： The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US11723990B2

公开(公告)日：2023-08-15

申请号：US17231922

申请日：2021-04-15

申请人： The Board of Regents of the University of Texas System

发明人： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC分类号： A61K8/73 ,  A61K8/06 ,  A61K49/00 ,  G01N21/64 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/10 ,  G01N33/58 ,  G01N33/84

CPC分类号： A61K49/0054 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0041 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/103 ,  C09B69/105 ,  C09B69/106 ,  C09B69/109 ,  G01N21/643 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/582 ,  G01N33/84 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441

摘要： The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US10098971B2

公开(公告)日：2018-10-16

申请号：US15369701

申请日：2016-12-05

申请人： The Board of Regents of the University of Texas System

发明人： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC分类号： A61K49/00 ,  G01N33/84 ,  G01N33/58 ,  C08F8/30 ,  C08F8/42 ,  C08F8/32 ,  C08F8/34 ,  C09B69/10 ,  G01N21/64

摘要： The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US11738053B2

公开(公告)日：2023-08-29

申请号：US16329915

申请日：2017-09-01

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Senlin Li ,  Robert A Clark ,  Cang Chen ,  Yang Li

IPC分类号： A01N63/00 ,  C12N15/63 ,  C07H21/04 ,  A61K35/28 ,  A61K38/19 ,  A01K67/027 ,  C12N15/86

CPC分类号： A61K35/28 ,  A01K67/0276 ,  A61K38/193 ,  C12N15/86 ,  A01K2227/105 ,  A01K2267/0306 ,  C12N2740/16043

摘要： The invention relates to a method of treating chronic granulomatous disease through Hematopoietic stem cell (HSC) transplantation. The method comprises the steps of administering stem cell mobilization agent to human such that the target stem cell population migrates from host niches into the subject's blood. The target stem cells are removed from blood and administering the therapeutic stem cells to human and said therapeutic stem cells are engineered to express gp91phox. The steps are repeated multiple times i.e. at least four times. The mobilization agents used in the invention are granulocyte-colony stimulating factor and AMD3100. The method of HSC transplantation is effective in treatment of chronic granulomatous disease.