公开(公告)号：US09719114B2

公开(公告)日：2017-08-01

申请号：US13804185

申请日：2013-03-14

Applicant: TerraVia Holdings, Inc.

Inventor： Scott Franklin ,  Aravind Somanchi ,  George Rudenko ,  Riyaz Bhat ,  Xinhua Zhao ,  Risha Bond ,  Walter Rakitsky ,  Alejandro Marangoni

IPC: C12P7/64 ,  C12N9/02 ,  C12N9/26 ,  C10L1/02 ,  A23D9/02 ,  C11B11/00

CPC classification number: C12P7/64 ,  A23D9/02 ,  C10L1/026 ,  C11B11/00 ,  C12N9/0071 ,  C12N9/2431 ,  C12P7/6463 ,  C12P7/649 ,  C12Y114/19002 ,  C12Y301/03002 ,  Y02E50/13 ,  Y02T50/678

Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.

公开(公告)号：US09551017B2

公开(公告)日：2017-01-24

申请号：US14975137

申请日：2015-12-18

Applicant: TerraVia Holdings, Inc.

Inventor： Scott Franklin ,  Aravind Somanchi ,  George Rudenko ,  Riyaz Bhat ,  Xinhua Zhao ,  Risha Bond ,  Walter Rakitsky ,  Alejandro Marangoni ,  Diza Braksmayer

IPC: C12N1/12 ,  C12P7/64 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  A23D9/00 ,  C07C57/03 ,  C07J9/00 ,  C12P33/00 ,  C12N15/82 ,  A23D9/013 ,  C11B1/00 ,  C12N9/24 ,  C12N15/113 ,  C12R1/89

CPC classification number: C12P7/6409 ,  A23D9/00 ,  A23D9/013 ,  C07C57/03 ,  C07J9/00 ,  C11B1/00 ,  C12N9/0071 ,  C12N9/1029 ,  C12N9/16 ,  C12N9/2402 ,  C12N15/113 ,  C12N15/8247 ,  C12N2310/531 ,  C12P7/64 ,  C12P7/6445 ,  C12P7/6463 ,  C12P7/6472 ,  C12P33/00 ,  C12R1/89 ,  C12Y203/01015 ,  C12Y203/0102 ,  C12Y203/01041 ,  C12Y203/01051 ,  C12Y203/01179 ,  C12Y203/0118 ,  C12Y302/01014 ,  C12Y302/01026 ,  Y02E50/13 ,  Y02P20/52

Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.

Abstract translation: 重组DNA技术用于产生产生具有所需脂肪酸谱和区域特异性或立体特异性谱的甘油三酯油的含油重组细胞。 基因操作包括编码硬脂酰-ACP脱氧酶，δ12脂肪酸去饱和酶，酰基-ACP硫酯酶，酮酰基-ACP合成酶和溶血磷脂酰基转移酶的那些。 所生产的油可以具有增强的氧化或热稳定性，或可用作煎炸油，起酥油，卷入起酥油，回火脂肪，可可脂替代物，润滑剂或用作各种化学方法的原料。 脂肪酸分布可以富集中链型，或者油可富含饱和不饱和饱和型甘油三酸酯。

公开(公告)号：US20160376617A1

公开(公告)日：2016-12-29

申请号：US15179253

申请日：2016-06-10

Applicant: TerraVia Holdings, Inc.

Inventor： Scott Franklin ,  Walter Rakitsky ,  George Rudenko ,  Xinhua Zhao ,  Felipe Arana Rodriguez ,  Wenhua Lu ,  Janice Wee

IPC: C12P7/64 ,  H01F27/32 ,  C12N15/79 ,  A23D9/02 ,  H01B3/20 ,  C12N9/42

CPC classification number: C12P7/6463 ,  A23D9/007 ,  A23D9/02 ,  C10M169/041 ,  C11B1/025 ,  C11B1/06 ,  C11B1/10 ,  C11B3/001 ,  C11B3/006 ,  C11B3/008 ,  C11B3/06 ,  C11B3/10 ,  C11B3/14 ,  C12N9/2442 ,  C12N15/79 ,  C12P7/6409 ,  C12Y301/02014 ,  H01B3/20 ,  H01F27/105 ,  H01F27/321

Abstract: Methods and compositions for the production of dielectric fluids from lipids produced by microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a lipid pathway modification enzyme, a fatty acyl-ACP thioesterase, a desaturase, a fatty acyl-CoA/aldehyde reductase, and/or an acyl carrier protein are useful in manufacturing dielectric fluids.

Abstract translation: 提供了由微生物产生的脂质生产介电流体的方法和组合物，包括含油微生物和这种微生物的低成本培养方法。 含有编码例如蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖分解酶，脂质途径修饰酶，脂肪酰基-ACP硫酯酶，去饱和酶，脂肪酰辅酶A /醛的外源基因的微藻细胞 还原酶和/或酰基载体蛋白质可用于制造介电流体。

公开(公告)号：US09657299B2

公开(公告)日：2017-05-23

申请号：US14975016

申请日：2015-12-18

Applicant: TerraVia Holdings, Inc.

Inventor： Scott Franklin ,  Aravind Somanchi ,  Janice Wee ,  George Rudenko ,  Jeffrey L. Moseley ,  Walter Rakitsky

IPC: C12N1/20 ,  C12P7/64 ,  A23D7/00 ,  A23D9/00 ,  C11C3/00 ,  C11B1/00 ,  A23K1/16 ,  C12N15/79 ,  C12N9/16 ,  C12N15/82 ,  A23K20/158 ,  C12N9/02 ,  C12N9/26 ,  C12N9/40 ,  C12N15/67

CPC classification number: C12N15/79 ,  A23D7/00 ,  A23D9/00 ,  A23K20/158 ,  C11B1/00 ,  C11C3/00 ,  C12N9/0071 ,  C12N9/16 ,  C12N9/2431 ,  C12N9/2465 ,  C12N15/67 ,  C12N15/8216 ,  C12P7/64 ,  C12P7/6445 ,  C12P7/6463 ,  C12Y114/19001 ,  C12Y301/02 ,  C12Y301/02014 ,  C12Y302/01022 ,  C12Y302/01026 ,  Y02E50/13 ,  Y02P30/20 ,  Y02T50/678

Abstract: Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.

公开(公告)号：US09593351B2

公开(公告)日：2017-03-14

申请号：US14626505

申请日：2015-02-19

Applicant: TerraVia Holdings, Inc.

Inventor： Scott Franklin ,  Aravind Somanchi ,  Karen Espina ,  George Rudenko ,  Penelope Chua

IPC: C12N15/62 ,  C12P7/64 ,  C10L1/02 ,  C12N9/00 ,  C12N9/16 ,  C12P7/20 ,  C12N15/79 ,  C07C1/207 ,  C12N9/24

CPC classification number: C12P7/6427 ,  C07C1/2078 ,  C07K2319/01 ,  C10L1/02 ,  C12N9/00 ,  C12N9/16 ,  C12N9/2402 ,  C12N15/79 ,  C12P7/20 ,  C12P7/64 ,  C12P7/6409 ,  C12P7/6418 ,  C12P7/6463 ,  C12P7/649 ,  C12Y301/02014 ,  C12Y302/01026 ,  Y02E50/13 ,  Y02P20/52 ,  Y02P60/877 ,  Y02T50/678

Abstract: Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed. Novel oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods of the invention.

Abstract translation: 本文公开了通过制备新型甘油三酯油然后化学改性油来制造可再生化学品的方法。 公开了酯交换，氢化，加氢裂化，脱氧，异构化，酯交换，羟基化，水解和皂化等方法。 还公开了含有C8，C10，C12或C14脂肪酸链长度的新型油，并且可用作本发明方法中的原料。

公开(公告)号：US20170145450A1

公开(公告)日：2017-05-25

申请号：US15369557

申请日：2016-12-05

Applicant: TerraVia Holdings, Inc.

Inventor： Scott Franklin ,  Aravind Somanchi ,  George Rudenko ,  Riyaz Bhat ,  Xinhua Zhao ,  Risha Bond ,  Walter Rakitsky ,  Alejandro Marangoni ,  Diza Braksmayer

IPC: C12P7/64

CPC classification number: C12P7/6409 ,  A23D9/00 ,  A23D9/013 ,  C07C57/03 ,  C07J9/00 ,  C11B1/00 ,  C12N9/0071 ,  C12N9/1029 ,  C12N9/16 ,  C12N9/2402 ,  C12N15/113 ,  C12N15/8247 ,  C12N2310/531 ,  C12P7/64 ,  C12P7/6445 ,  C12P7/6463 ,  C12P7/6472 ,  C12P33/00 ,  C12R1/89 ,  C12Y203/01015 ,  C12Y203/0102 ,  C12Y203/01041 ,  C12Y203/01051 ,  C12Y203/01179 ,  C12Y203/0118 ,  C12Y302/01014 ,  C12Y302/01026 ,  Y02E50/13 ,  Y02P20/52

Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsatturated-saturated type.