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    Air-cooling micro drop pill capsule production line
    2.
    发明授权
    Air-cooling micro drop pill capsule production line 有权

    公开(公告)号：US10111811B2

    公开(公告)日：2018-10-30

    申请号：US14903789

    申请日：2014-07-11

    Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.

    Inventor： Xijun Yan ,  Xiaobing Sun ,  Yongfeng Zheng ,  Lijun Fan ,  Yan Fu

    IPC: A61J3/00 ,  B01J2/18 ,  B01J2/04 ,  B01J2/02 ,  A61J3/06

    Abstract: An air-cooling micro drop pill capsule production line comprises a drop pill system, an air-cooling circulation system and a control system. The drop pill system comprises a molten material tank and a dripper. A vibration apparatus is arranged between the molten material tank and the dripper, and drives the dripper to vibrate up and down. A vibration shear force cuts liquor flowing out from the dripper into drops, and drop pills are formed after the drops fall into the air-cooling circulation system and are cooled. An online monitoring apparatus is arranged on the dripper, and comprises a pulse signal emission mechanism with an emission frequency which is the same as a vibration frequency of the vibration apparatus. The control system controls and regulates a dropping parameter according to a monitoring result of the online monitoring apparatus. The present invention combines vibration dropping, online monitoring and controlling, air cooling, and fluidized drying and coating together, which satisfies the requirement of high-speed dropping, micro pill preparation and improving a drug-loading capacity. Thus, the drug-loading capacity of drop pills can be multiply improved, the usage of auxiliary materials and the dosage can be greatly reduced, organic solvent residual can be completely avoided, and requirements of different processes including slow-release coating, film coating and sugar coating can be satisfied.

    AIR-COOLING MICRO DROP PILL CAPSULE PRODUCTION LINE
    4.
    发明申请
    AIR-COOLING MICRO DROP PILL CAPSULE PRODUCTION LINE 审中-公开
    空气冷却微粉碎胶囊生产线

    公开(公告)号：US20160166472A1

    公开(公告)日：2016-06-16

    申请号：US14903789

    申请日：2014-07-11

    Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.

    Inventor： Xiyun Yan ,  Xiaobing Sun ,  Yongfeng Zheng ,  Lijun Fan ,  Yan Fu

    IPC: A61J3/00 ,  A61J3/06

    CPC classification number: A61J3/005 ,  A61J3/06 ,  A61J2200/42 ,  A61J2200/44 ,  B01J2/02 ,  B01J2/04 ,  B01J2/18

    Abstract: An air-cooling micro drop pill capsule production line comprises a drop pill system, an air-cooling circulation system and a control system. The drop pill system comprises a molten material tank and a dripper. A vibration apparatus is arranged between the molten material tank and the dripper, and drives the dripper to vibrate up and down. A vibration shear force cuts liquor flowing out from the dripper into drops, and drop pills are formed after the drops fall into the air-cooling circulation system and are cooled. An online monitoring apparatus is arranged on the dripper, and comprises a pulse signal emission mechanism with an emission frequency which is the same as a vibration frequency of the vibration apparatus. The control system controls and regulates a dropping parameter according to a monitoring result of the online monitoring apparatus. The present invention combines vibration dropping, online monitoring and controlling, air cooling, and fluidized drying and coating together, which satisfies the requirement of high-speed dropping, micro pill preparation and improving a drug-loading capacity. Thus, the drug-loading capacity of drop pills can be multiply improved, the usage of auxiliary materials and the dosage can be greatly reduced, organic solvent residual can be completely avoided, and requirements of different processes including slow-release coating, film coating and sugar coating can be satisfied.

    Abstract translation: 空冷微滴丸胶囊生产线包括滴丸系统，空气冷却循环系统和控制系统。 滴丸系统包括熔融材料罐和滴液器。 在熔融材料罐和滴水器之间设置振动装置，驱动滴水器上下振动。 振动剪切力将从滴液器流出的液体切割成液滴，并且在液滴落入空气冷却循环系统之后形成滴丸，并冷却。 一种在线监测装置设置在滴液器上，并且包括具有与振动装置的振动频率相同的发射频率的脉冲信号发射机构。 控制系统根据在线监控装置的监控结果控制和调节丢弃参数。 本发明将振动降落，在线监测和控制，空气冷却，流化干燥和涂层结合在一起，满足高速滴下，微丸制备和提高载药能力的要求。 因此，滴丸的药物负载能力可以提高，可以大大减少辅料的用量和用量，可以完全避免有机溶剂残留，不同方法的要求包括缓释涂膜，薄膜包衣和 糖衣可以满足。

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