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    Intelligent continuous manufacturing method via liquid cooling of dripping pills
    5.
    发明授权
    Intelligent continuous manufacturing method via liquid cooling of dripping pills 有权

    公开(公告)号：US10813840B2

    公开(公告)日：2020-10-27

    申请号：US15760367

    申请日：2016-09-14

    申请人： TASLY PHARMACEUTICAL GROUP CO., LTD.

    发明人： Kaijing Yan ,  Xiaobing Sun ,  Changsheng Rong ,  Xuefei Cai ,  Liang Wang

    IPC分类号： A61J3/06 ,  A61K9/20

    摘要： An intelligent continuous manufacturing method via liquid cooling of dripping pills comprises the following steps: (1) feeding: weighing and transferring multiple materials respectively; (2) material combining: performing staged heating on the materials transferred in step (1), and mixing the same to obtain a material mixture, wherein an RSD of an effective ingredient in the material mixture ≤5%; (3) homogenizing: pressurizing the material mixture obtained in step (2), and increasing the temperature, so as to obtain a homogenized material having the RSD of the effective ingredient in the material mixture ≤5%; (4) dripping: performing vibration dripping on the homogenized material obtained in step (3) to obtain dripping pills, delivering the dripping pills into a cooling liquid to be cooled and then transferred; and (5) de-oiling: removing the cooling liquid on surfaces of the dripping pills obtained in step (4) via tilting centrifugation. The manufacturing method not only shortens the manufacturing process, but also ensures the dripping pill product to be more stable and homogeneous. In addition, high-speed centrifugation is used to reasonably de-oil the dripping pills to prevent contamination of the dripping pills and improve the circulation utilization rate of the cooling liquid.