公开(公告)号：US10376490B2

公开(公告)日：2019-08-13

申请号：US15560578

申请日：2016-03-22

Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.

Inventor： Naifeng Wu ,  Xijun Yan ,  He Sun ,  Kaijing Yan ,  Yonghong Zhu ,  Shunnan Zhang ,  Xiaolin Bai ,  Yi He ,  Xiaohui Ma ,  Ting Li

IPC: A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K36/82 ,  A61K47/24 ,  B65D81/32 ,  A61K31/357

Abstract: A pharmaceutical composition for treating non-alcoholic fatty liver diseases consists of a silybin-phospholipid complex preparation and Pu'er tea/tea product according to a weight ratio of 0.5-2.5:0.3-10, wherein the silybin-phospholipid complex capsule preparation and the Pu'er teat/tea product are separately packaged.

公开(公告)号：US10307395B2

公开(公告)日：2019-06-04

申请号：US15560560

申请日：2016-03-22

Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.

Inventor： He Sun ,  Xijun Yan ,  Naifeng Wu ,  Kaijing Yan ,  Yonghong Zhu ,  Shunnan Zhang ,  Xiaolin Bai ,  Xiaohui Ma ,  Yi He ,  Ting Li ,  Lei Li

IPC: A61K36/00 ,  A61K31/357 ,  A61K36/82 ,  A61K47/24 ,  A61K9/48 ,  A61K31/205 ,  A61P1/16 ,  A61K9/16 ,  A61K31/355 ,  A61K31/683 ,  A61K9/08 ,  A61K36/488

Abstract: A pharmaceutical composition for treating non-alcoholic fatty liver diseases. The pharmaceutical composition is prepared from 8.75-60 parts by weight of silybin, 15-65 parts by weight of phospholipid, 25-150 parts by weight of a Pu'er tea extract, and 10.425-60 parts by weight of L-carnitine.

公开(公告)号：USRE49035E1

公开(公告)日：2022-04-19

申请号：US16715485

申请日：2019-12-16

Applicant: Tasly Pharmaceutical Group Co., Ltd.

Inventor： Xijun Yan ,  Naifeng Wu ,  Kaijing Yan ,  Zhengliang Ye ,  Shunnan Zhang ,  Lihong Zhou ,  Wensheng Zhang ,  Hai'ou Dong

IPC: A61K36/00 ,  A61K31/216 ,  A61K31/343 ,  A61K31/192 ,  A61K9/20 ,  A61K31/045 ,  A61K36/258 ,  A61K36/537 ,  A61K9/28 ,  A61K31/704 ,  A61K9/16 ,  A61K31/11 ,  A61K36/82

Abstract: A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.

公开(公告)号：US11013694B2

公开(公告)日：2021-05-25

申请号：US16422857

申请日：2019-05-24

Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.

Inventor： Xijun Yan ,  Naifeng Wu ,  Kaijing Yan ,  Xiaobing Sun ,  Shunnan Zhang ,  Zhengliang Ye ,  Hai'ou Dong ,  Hongbo Zhang ,  Wensheng Zhang ,  Lihong Zhou ,  Chenming Li ,  Cong Chen ,  Xiaofeng Liu ,  Shiqing Wang ,  Changsheng Rong ,  Yongfeng Zheng ,  Lijun Fan

IPC: A61K9/20 ,  A61K36/537 ,  A61K36/258 ,  A61K45/06 ,  A61J3/06 ,  A61K9/50 ,  A61K36/48 ,  A61K36/481

Abstract: The present invention relates to a preparation method for a traditional Chinese medicine drop pill and a traditional Chinese medicine micro drop pill prepared by using the method, and in particular, the present invention relates to a micro drop pill preparation method with high drug-loading capacity, simple preparation process and high production rate and a micro drop pill prepared by using the method. Specially, The drop pill preparation method used comprises the following steps: (1) material melting step: heat melting a medicine and a drop pill matrix to obtain a molten medicine liquid; (2) dropping step: delivering the molten medicine liquid to a dripper, and acquiring medicine drops of the molten medicine liquid by means of vibration dropping; and, (3) condensation step: cooling the medicine drops with a cooling gas to obtain micro drop pills.

公开(公告)号：US10300030B2

公开(公告)日：2019-05-28

申请号：US14910088

申请日：2014-08-28

Applicant: Tasly Pharmaceutical Group Co., Ltd.

Inventor： Xijun Yan ,  Naifeng Wu ,  Shunnan Zhang ,  Ping Li ,  Zhengliang Ye ,  Lihong Zhou ,  Lianwen Qi ,  Fenglian Zhang ,  Minchao Qi ,  Zhexuan Yang ,  Wei Sun ,  Jing Yu ,  Hua Yang ,  Peng Liu ,  Xiaohui Ma ,  Hai'ou Dong ,  Wensheng Zhang ,  Lanlan Zhang ,  Chenming Li

IPC: A61K31/192 ,  A61K31/704 ,  A61K36/537 ,  A61K31/7028 ,  A61K31/11 ,  A61K31/216 ,  A61K31/343 ,  A61K31/352 ,  A61K36/258

Abstract: A traditional Chinese medicine composition and preparation thereof for treating cardiovascular diseases is provided. The traditional Chinese medicine composition consists of: by weight percentage, phenolic acid derivatives 30%˜80%, tanshinones 2%˜10% and saponins 15%˜60%.

公开(公告)号：US10111811B2

公开(公告)日：2018-10-30

申请号：US14903789

申请日：2014-07-11

Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.

Inventor： Xijun Yan ,  Xiaobing Sun ,  Yongfeng Zheng ,  Lijun Fan ,  Yan Fu

IPC: A61J3/00 ,  B01J2/18 ,  B01J2/04 ,  B01J2/02 ,  A61J3/06

Abstract: An air-cooling micro drop pill capsule production line comprises a drop pill system, an air-cooling circulation system and a control system. The drop pill system comprises a molten material tank and a dripper. A vibration apparatus is arranged between the molten material tank and the dripper, and drives the dripper to vibrate up and down. A vibration shear force cuts liquor flowing out from the dripper into drops, and drop pills are formed after the drops fall into the air-cooling circulation system and are cooled. An online monitoring apparatus is arranged on the dripper, and comprises a pulse signal emission mechanism with an emission frequency which is the same as a vibration frequency of the vibration apparatus. The control system controls and regulates a dropping parameter according to a monitoring result of the online monitoring apparatus. The present invention combines vibration dropping, online monitoring and controlling, air cooling, and fluidized drying and coating together, which satisfies the requirement of high-speed dropping, micro pill preparation and improving a drug-loading capacity. Thus, the drug-loading capacity of drop pills can be multiply improved, the usage of auxiliary materials and the dosage can be greatly reduced, organic solvent residual can be completely avoided, and requirements of different processes including slow-release coating, film coating and sugar coating can be satisfied.

公开(公告)号：US09999630B2

公开(公告)日：2018-06-19

申请号：US14903995

申请日：2014-07-11

Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD

Inventor： Xijun Yan ,  Naifeng Wu ,  Kaijing Yan ,  Zhengliang Ye ,  Shunnan Zhang ,  Lihong Zhou ,  Wensheng Zhang ,  Hai'ou Dong

IPC: A61K36/00 ,  A61K31/704 ,  A61K36/537 ,  A61K36/258 ,  A61K31/045 ,  A61K9/20 ,  A61K31/192 ,  A61K31/216 ,  A61K31/343 ,  A61K9/28

CPC classification number: A61K31/704 ,  A61K9/16 ,  A61K9/1664 ,  A61K9/20 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2059 ,  A61K9/2068 ,  A61K9/2893 ,  A61K31/045 ,  A61K31/11 ,  A61K31/192 ,  A61K31/216 ,  A61K31/343 ,  A61K36/258 ,  A61K36/537 ,  A61K36/82 ,  A61K2300/00

Abstract: A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.

公开(公告)号：US20160175336A1

公开(公告)日：2016-06-23

申请号：US14903995

申请日：2014-07-11

Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.

Inventor： Xijun Yan ,  Naifeng Wu ,  Kaijing Yan ,  Zhengliang Ye ,  Shunnan Zhang ,  Lihong Zhou ,  Wensheng Zhang ,  Hai'ou Dong

IPC: A61K31/704 ,  A61K36/258 ,  A61K31/045 ,  A61K9/28 ,  A61K31/192 ,  A61K31/216 ,  A61K31/343 ,  A61K36/537 ,  A61K9/20

CPC classification number: A61K31/704 ,  A61K9/16 ,  A61K9/1664 ,  A61K9/20 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2059 ,  A61K9/2068 ,  A61K9/2893 ,  A61K31/045 ,  A61K31/11 ,  A61K31/192 ,  A61K31/216 ,  A61K31/343 ,  A61K36/258 ,  A61K36/537 ,  A61K36/82 ,  A61K2300/00

Abstract: A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.

Abstract translation: 一种治疗心血管疾病的中药组合物及其制备方法，特别是其微滴丸制剂及其制备方法。 制备微滴丸制剂的方法可用于制备具有高药物负载能力的滴丸，包衣药丸和滴丸胶囊。

公开(公告)号：US11318112B2

公开(公告)日：2022-05-03

申请号：US15560573

申请日：2016-03-22

Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.

Inventor： He Sun ,  Xijun Yan ,  Naifeng Wu ,  Kaijing Yan ,  Yonghong Zhu ,  Shunnan Zhang ,  Xiaolin Bai ,  Xiaohui Ma ,  Yi He ,  Ting Li ,  Lei Li

IPC: A61K31/357 ,  A61K36/82 ,  A61K47/24 ,  A61K9/48 ,  A61K31/205 ,  A61P1/16 ,  A61K9/16 ,  A61K31/355 ,  A61K31/683 ,  A61K9/08 ,  A61K36/488

Abstract: A pharmaceutical composition is prepared from the following raw materials (in parts by weight): silybin (8.75-60), phospholipid (15-65), a Pu'er tea extract (25-200), and vitamin E (6.25-40). The composition has the effect of treating non-alcoholic fatty liver diseases.

公开(公告)号：US10507197B2

公开(公告)日：2019-12-17

申请号：US15560576

申请日：2016-03-22

Applicant: TASLY PHARMACEUTICAL GROUP CO., LTD.

Inventor： Naifeng Wu ,  Xijun Yan ,  He Sun ,  Kaijing Yan ,  Yonghong Zhu ,  Shunnan Zhang ,  Xiaolin Bai ,  Yi He ,  Xiaohui Ma ,  Ting Li ,  Lei Li

IPC: A61K31/357 ,  A61K36/82 ,  A61K47/24 ,  A61K9/48 ,  A61K31/205 ,  A61P1/16 ,  A61K9/16 ,  A61K31/355 ,  A61K31/683 ,  A61K9/08 ,  A61K36/488

Abstract: Disclosed is a pharmaceutical composition containing silibinin, which is prepared from the following bulk drugs by weight ratio: 8.75-60 parts of silibinin, 15-65 parts of phospholipid, and 25-200 parts of Pu'er tea extract. The drug has the function of treating non-alcoholic fatty liver.