公开(公告)号：US20030109755A1

公开(公告)日：2003-06-12

申请号：US10305938

申请日：2002-11-29

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Takeshi Yamamoto ,  Kenichiro Adachi ,  Shinya Watanabe ,  Hideo Ujihara ,  Toshimitsu Hagiwara

IPC: C07C045/66

CPC classification number: C07C45/67 ,  C07C45/62 ,  C07C45/66 ,  C07C45/72 ,  C07C49/597 ,  C07C49/647 ,  C07C49/493

Abstract: Industrially advantageous processes for producing a 2-alkyl-2-cyclopentenone in high yields starting from a 2-(1-hydroxyalkyl)cyclopentanone or a 2-alkylidenecyclopentanone, which are obtainable from a cyclopentanone and a carbonyl compound. A 2-(1-hydroxyalkyl)cyclopentanone represented by the following general formula (1): 1 (wherein R1, R2, R3, R4, R5, R6 and R7 each independently represents hydrogen atom, an alkyl group having 1 to 10 carbon atoms which may have one or more substituents or an aromatic group which may have one or more substituents, and each of (1) R6 or R7 with R3 and (2) R6 or R7 with R4 or R5 may be together combined to form a ring which may have a double bond) is subjected to dehydrative isomerization in the presence of a bromine compound and/or an iodine compound.

Abstract translation: 从可从环戊酮和羰基化合物得到的2-（1-羟烷基）环戊酮或2-亚烷基环戊酮开始以高产率制备2-烷基-2-环戊烯酮的工业上有利的方法。 由下列通式（1）表示的2-（1-羟烷基）环戊酮：其中R1，R2，R3，R4，R5，R6和R7各自独立地表示氢原子，碳原子数1〜10的烷基， 可以具有一个或多个取代基或可以具有一个或多个取代基的芳族基团，并且（1）R 6或R 7与R 3和（2）R 6或R 7与R 4或R 5的每一个可以一起组合形成环， 具有双键）在溴化合物和/或碘化合物的存在下进行脱水异构化。

公开(公告)号：US20020128525A1

公开(公告)日：2002-09-12

申请号：US10098358

申请日：2002-03-18

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Shinya Yamada ,  Yoshiki Okeda ,  Yoji Hori ,  Toshimitsu Hagiwara

IPC: C07C029/56

CPC classification number: C07C209/68 ,  C07B2200/07 ,  C07C29/141 ,  C07C33/025 ,  C07C45/42 ,  C07C47/21 ,  C07C211/21

Abstract: Provided is citronellol, which has an elegant rosy fragrance and is extremely useful for fragrance impartation to aromatic articles A mixture of an alkylamine and isoprene in a molar ratio of from 1:4 to 1:4.5 is subjected to telomerization at 80 to 100null C. for 2.5 to 3.5 hours in the presence of an alkyllithium catalyst and/or phenyllithium catalyst to obtain a nerylamine compound containing 2 to 10 wt % null-nerylamine compound represented by general formula (4). 1 From this nerylamine compound, citronellol containing 2 to 10 wt % optically active 3,7-dimethyl-7-octenol is produced through the reaction steps of asymmetric isomerization, hydrolysis, and hydrogenation.

Abstract translation: 提供香茅醇，其具有优雅的玫瑰色香料，并且对于赋予芳香族物品的香料非常有用。将摩尔比为1:4至1:4.5的烷基胺和异戊二烯的混合物在80至100℃下进行调聚 在烷基锂催化剂和/或苯基锂催化剂存在下进行2.5至3.5小时，得到含有通式（4）表示的2-10重量％α-椰子胺化合物的橙花胺化合物。 通过非对称异构化，水解和氢化的反应步骤，由该橙花胺化合物制备含有2-10重量％光学活性的3,7-二甲基-7-辛烯醇的香茅醇。

公开(公告)号：US20030207789A1

公开(公告)日：2003-11-06

申请号：US10390752

申请日：2003-03-19

Applicant: Takasago International Corporation

Inventor： Takeshi Yamamoto ,  Shinya Watanabe ,  Hideo Ujihara ,  Toshimitsu Hagiwara

IPC: A61K007/46

CPC classification number: C11B9/0034

Abstract: A geometrical isomer composition excellent in odor and in chemical resistance, which is applicable to a base material containing a strongly alkaline chemical or a strongly acidic chemical, which can suppress the deterioration with time and the color change of the base material in the case that the material is exposed to light, and which also have highly palatable and unique fruity floral fragrance. The composition is produced by mixing 93 to 99% by weight of optically active ethyl trans-2,2,6-trimethylcyclohexylcarboxylate represented by Formula-1 or a mixture thereof and 7 to 1% by weight of optically active ethyl cis-2,2,6-trimethylcyclohexylcarboxylate represented by Formula-2 or a mixture thereof, respectively. 1

Abstract translation: 适用于含有强碱性化学品或强酸性化学物质的基材的气味和耐化学性优异的几何异构体组合物，其能够抑制随着时间的劣化和基材的颜色变化， 材料暴露于光，而且还具有高度可口和独特的果香花香。 该组合物通过将93至99重量％的由式-1或其混合物表示的反式-2,2,6-三甲基环己基羧酸酯的旋光活性乙酯和7至1重量％的旋光活性乙基顺式-2,2 ，分别由式-2表示的6-三甲基环己基羧酸酯或其混合物。

公开(公告)号：US20020035295A1

公开(公告)日：2002-03-21

申请号：US09946468

申请日：2001-09-06

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Mitsuhiko Fujiwara ,  Ken Suzuki ,  Tohru Kobayashi ,  Yoji Hori ,  Toshimitsu Hagiwara

IPC: C07C29/04 ,  C07C29/06

CPC classification number: C07C209/10 ,  C07C211/54

Abstract: The present invention provides an activator in arylamination using a palladium compound as a catalyst, which is superior to conventional phosphines in stability and performance. With the phosphine sulfide as an activator, an arylamination reaction achieves improved selectivity to produce a desired aromatic amine in an obviously increased yield as compared with a reaction using the corresponding phosphine compound. Moreover, the phosphine sulfide of the invention is impervious to oxidation and exists stably in air and therefore sufficiently withstands use on an industrial scale.

Abstract translation: 本发明提供使用钯化合物作为催化剂的芳基化活化剂，其在稳定性和性能方面优于常规膦。 与使用相应的膦化合物的反应相比，以硫化氢作为活化剂，芳基化反应实现了以明显增加的产率产生所需芳族胺的选择性。 此外，本发明的硫化膦不能氧化，在空气中稳定地存在，因此能够充分地耐受工业规模的使用。

公开(公告)号：US20020012649A1

公开(公告)日：2002-01-31

申请号：US09874312

申请日：2001-06-06

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Izumi Kawada ,  Kenya Ishida ,  Kiyohito Sawano ,  Toshimitsu Hagiwara

IPC: A61K007/075 ,  A61K007/08

CPC classification number: A61Q19/00 ,  A61K8/0295 ,  A61K8/63 ,  A61K8/68 ,  A61K9/1274 ,  A61Q1/08 ,  A61Q17/00

Abstract: This invention relates to a novel lipid composition for use in cosmetics capable of increasing moisture-keeping ability or barrier function of the stratum corneum, protecting the skin and improving dry or rough skin, and to products which use the same, such as cosmetics and medicaments. Particularly, it relates to a lipid composition which comprises at least one component (A) selected from the group consisting of a 2-acylaminoalkane-1,3-diol and optically active compounds thereof, at least one component (B) selected from the group consisting of a 2-acylaminoalkane-1,3-diol in which at least one of the null-position and null-position of the acyl group is substituted with hydroxyl group and optically active compounds thereof and at least one component (C) selected from sterols, wherein the components (A), (B) and (C) are mixed at a ratio that constructs a liquid crystal structure, and to products which contain the lipid composition, such as cosmetics and medicaments.

Abstract translation: 本发明涉及一种用于化妆品的新型脂质组合物，其能够增加角质层的保湿能力或屏障功能，保护皮肤和改善干性或粗糙皮肤，以及使用其的产品，例如化妆品和药物 。 特别涉及含有选自2-酰基氨基链烷-1,3-二醇及其光学活性化合物中的至少一种成分（A）的至少一种成分（A），至少一种选自 由其中酰基的α-位和β-位中的至少一个被羟基取代的2-酰基氨基烷-1,3-二醇和其光学活性化合物和至少一种选自以下的组分（C）组成： 固醇，其中组分（A），（B）和（C）以构成液晶结构的比例和包含脂质组合物的产品如化妆品和药物混合。

公开(公告)号：US20030207790A1

公开(公告)日：2003-11-06

申请号：US10390733

申请日：2003-03-19

Applicant: Takasago International Corporation

Inventor： Takeshi Yamamoto ,  Shinya Watanabe ,  Hideo Ujihara ,  Toshimitsu Hagiwara

IPC: A61K007/46

CPC classification number: C07C403/16 ,  C07B2200/07 ,  C07C45/002 ,  C07C45/292 ,  C07C45/54 ,  C07C2601/14 ,  C11B9/0034 ,  C07C49/303 ,  C07C49/203

Abstract: A geometrical isomer composition excellent in odor and in chemical resistance, which is applicable to a base material containing a strongly alkaline chemical or a strongly acidic chemical, which can suppress the deterioration with time and the color change of the base material in the case that the material is exposed to light, and which also have highly tasteful and unique fruity floral fragrance. A geometrical isomer composition containing 93 to 99% by weight of optically active trans-1-(2,2,6-trimethylcyclohexyl)-2-buten-1-one represented by Formula-1 or a mixture thereof and 7 to 1% by weight of optically active cis-1-(2,2,6-trimethylcyclohexyl)-2-buten-1-one represented by Formula-2 or a mixture thereof is, respectively, used. 1

Abstract translation: 适用于含有强碱性化学品或强酸性化学物质的基材的气味和耐化学性优异的几何异构体组合物，其能够抑制随着时间的劣化和基材的颜色变化， 材料曝光，并且还具有高度品味和独特的水果花香。 含有93〜99重量％的由式-1表示的光学活性的反式-1-（2,2,6-三甲基环己基）-2-丁烯-1-酮或其混合物和7〜1重量％ 分别使用由式-2表示的光学活性顺式-1-（2,2,6-三甲基环己基）-2-丁烯-1-酮或其混合物的重量。

公开(公告)号：US20020156327A1

公开(公告)日：2002-10-24

申请号：US10115096

申请日：2002-04-04

Applicant: Takasago International Corporation

Inventor： Akira Amano ,  Teruyoshi Akiyama ,  Takashi Miura ,  Toshimitsu Hagiwara

IPC: C07C041/03 ,  C07C043/196

CPC classification number: C07C41/26 ,  C07B2200/07 ,  C07C41/03 ,  C07C41/42 ,  C07C67/11 ,  C07C2601/14 ,  C07C69/16 ,  C07C69/08 ,  C07C43/196

Abstract: A method for safely and efficiently producing high purity 3-l-menthoxypropane-1,2-diol and intermediates to be used in the method. As shown in the following reaction formula, 3-l-menthoxypropane-1,2-diol represented by the chemical formula (IV) is produced by adding l-menthol to a 1,2-epoxy-3-halogenopropane represented by the general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid, thereby producing a 1-halogeno-3-l-menthoxypropan-2-ol represented by the general formula (II), allowing the first intermediate to react with an alkali metal salt of an aliphatic carboxylic acid having from 1 to 5 carbon atoms to produce a 1-acyloxy-2-substituted-3-l-menthoxypropane represented by the general formula (III) and then hydrolyzing the second intermediate.

Abstract translation: 一种安全有效地生产高纯度3,1-薄荷氧基丙烷-1,2-二醇的方法和用于该方法的中间体。 如以下反应式所示，由化学式（IV）表示的3,1-薄荷氧基丙烷-1,2-二醇通过将1-薄荷醇加入由通式（I）表示的1,2-环氧-3-氯代丙烷 （I）（其中X表示卤素原子）在有机溶剂中在路易斯酸存在下反应，得到通式（II）表示的1-卤代-3-基-1-薄荷氧基丙-2-醇， 与具有1至5个碳原子的脂族羧酸的碱金属盐反应以产生由通式（III）表示的1-酰氧基-2-取代的3-l-薄荷氧基丙烷，然后水解第二个 中间。

公开(公告)号：US20020054893A1

公开(公告)日：2002-05-09

申请号：US09949718

申请日：2001-09-12

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Kenya Ishida ,  Takashi Nishida ,  Hiroyuki Matsuda ,  Hisao Iwai ,  Toshimitsu Hagiwara

IPC: A61K007/46

CPC classification number: A61Q13/00 ,  A23L2/56 ,  A61K8/34 ,  C11B9/0034

Abstract: A fragrance composition having an excellent diffusivity and long-lasting property of fragrance and a cosmetic, toiletry, bath composition, food and drink and pharmaceutical having an excellent diffusivity and long-lasting property of fragrance by using a novel fixative. A compound represented by the following general formula (1) is incorporated in a fragrance composition or the foregoing products. The amount of the compound of the general formula (1) to be incorporated in the fragrance composition is preferably from 0.01 to 90% by weight. The amount of the compound of the general formula (1) to be incorporated directly in the foregoing products is preferably from 0.0001 to 2.0 times (by weight) the weight of the aroma composition and/or composition to be incorporated therein. In this arrangement, a fragrance composition or products having an enhanced diffusivity and long-lasting property of fragrance can be obtained without causing any safety problem on human being. 1 wherein A represents H or OH group; B represents H or methyl group; and n represents an integer of from 0 to 2.

Abstract translation: 通过使用新型固定剂，具有优异的香味散发性和持久性的香料组合物和具有优异的香味散发性和持久性的化妆品，化妆品，浴用组合物，食品和饮料以及药物。 将由以下通式（1）表示的化合物引入香料组合物或前述产品中。 掺入香料组合物中的通式（1）化合物的量优选为0.01至90重量％。 直接加入到上述产品中的通式（1）化合物的量优选为其中加入的香料组合物和/或组合物的重量的0.0001至2.0倍（重量）。 在这种布置中，可以获得具有增强的香味扩散性和持​​久性的香料组合物或产品，而不会对人造成任何安全问题。 其中A表示H或OH基; B表示H或甲基; n表示0〜2的整数。

公开(公告)号：US20020004615A1

公开(公告)日：2002-01-10

申请号：US09875158

申请日：2001-06-07

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Shinya Watanabe ,  Hideo Ujihara ,  Takeshi Yamamoto ,  Toshimitsu Hagiwara

IPC: C07C315/00 ,  C07C317/00

CPC classification number: C07C403/16 ,  C07C45/67 ,  C07C45/69 ,  C07C2601/16 ,  C07C49/543

Abstract: An economical process for producing (2- and/or 1-)cyclohexenyl methyl ketones which are intermediates for the synthesis of null- or null-damascone. In the presence of a catalyst, a 3-cyclohexenyl methyl ketone represented by the following formula (1a): 1 wherein, R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and at least two of R1, R2 and R3 are methyl groups, is isomerized.

Abstract translation: 用于生产（2-和/或1-）环己烯基甲基酮的经济方法，其是用于合成α-大脑皮质或大黄酮的中间体。 在催化剂存在下，由下式（1a）表示的3-环己烯基甲基酮：其中，R 1，R 2和R 3各自独立地表示氢原子或甲基，R 1，R 2和R 3中的至少两个为 甲基，异构化。