公开(公告)号：US20030004362A1

公开(公告)日：2003-01-02

申请号：US10142983

申请日：2002-05-13

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Kenichi Tada ,  Takashi Miura

IPC: C07C067/30 ,  C07C069/66

CPC classification number: C07C67/31 ,  C07C69/675

Abstract: A novel production process capable of obtaining an optically active alcohol in a high optical purity by subjecting a null-keto ester such as a 3-perfluoroalkyl-3-oxopropionate ester or a 3-trichloroalkyl-3-oxopropionate ester to asymmetric reduction in simple and convenient operations.

Abstract translation: 一种能够通过使3-酮基酯如3-全氟烷基-3-氧代丙酸酯或3-三氯烷基-3-氧代丙酸酯通过使简单且不饱和的不对称还原得到高光学纯度的光学活性醇的新型制备方法 方便操作。

公开(公告)号：US20020156327A1

公开(公告)日：2002-10-24

申请号：US10115096

申请日：2002-04-04

Applicant: Takasago International Corporation

Inventor： Akira Amano ,  Teruyoshi Akiyama ,  Takashi Miura ,  Toshimitsu Hagiwara

IPC: C07C041/03 ,  C07C043/196

CPC classification number: C07C41/26 ,  C07B2200/07 ,  C07C41/03 ,  C07C41/42 ,  C07C67/11 ,  C07C2601/14 ,  C07C69/16 ,  C07C69/08 ,  C07C43/196

Abstract: A method for safely and efficiently producing high purity 3-l-menthoxypropane-1,2-diol and intermediates to be used in the method. As shown in the following reaction formula, 3-l-menthoxypropane-1,2-diol represented by the chemical formula (IV) is produced by adding l-menthol to a 1,2-epoxy-3-halogenopropane represented by the general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid, thereby producing a 1-halogeno-3-l-menthoxypropan-2-ol represented by the general formula (II), allowing the first intermediate to react with an alkali metal salt of an aliphatic carboxylic acid having from 1 to 5 carbon atoms to produce a 1-acyloxy-2-substituted-3-l-menthoxypropane represented by the general formula (III) and then hydrolyzing the second intermediate.

Abstract translation: 一种安全有效地生产高纯度3,1-薄荷氧基丙烷-1,2-二醇的方法和用于该方法的中间体。 如以下反应式所示，由化学式（IV）表示的3,1-薄荷氧基丙烷-1,2-二醇通过将1-薄荷醇加入由通式（I）表示的1,2-环氧-3-氯代丙烷 （I）（其中X表示卤素原子）在有机溶剂中在路易斯酸存在下反应，得到通式（II）表示的1-卤代-3-基-1-薄荷氧基丙-2-醇， 与具有1至5个碳原子的脂族羧酸的碱金属盐反应以产生由通式（III）表示的1-酰氧基-2-取代的3-l-薄荷氧基丙烷，然后水解第二个 中间。