公开(公告)号：US12054714B2

公开(公告)日：2024-08-06

申请号：US17114443

申请日：2020-12-07

申请人： Sirnaomics, Inc.

发明人： Xiaoyong Lu ,  Patrick Y. Lu ,  David M. Evans

IPC分类号： C07K7/08 ,  A61K47/64 ,  C07K7/06 ,  C12N15/113 ,  C12N15/117

CPC分类号： C12N15/113 ,  A61K47/64 ,  C07K7/08 ,  C12N15/117 ,  C07K7/06 ,  C12N2310/11 ,  C12N2310/127 ,  C12N2310/13 ,  C12N2310/141 ,  C12N2310/16 ,  C12N2310/3513

摘要： Peptide docking vehicle compositions containing a therapeutic compound, such as an siRNA molecule, and a targeting ligand are provided, together with methods for their preparation and use. The compositions and methods allow targeted cell/tissue delivery of the therapeutic compound to a subject by linking a targeting ligand to the compound to provide enhanced therapeutic benefit. The subject may be an animal or a human.

公开(公告)号：US20190030187A1

公开(公告)日：2019-01-31

申请号：US15758312

申请日：2016-09-07

申请人： Sirnaomics, Inc.

发明人： Patrick Y. Lu ,  Vera Simonenko ,  Yibin Cai ,  John Xu ,  David Evans

IPC分类号： A61K48/00 ,  A61P31/14 ,  A61K47/54 ,  A61K47/28 ,  C12N15/113

摘要： The present invention relates to compositions and methods for siRNA therapeutics for prevention and treatment of Middle East Respiratory Syndrome Corona Virus (MERS-CoV) infections. The compositions include a pharmaceutical composition comprising siRNA cocktails that target viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers.

公开(公告)号：US12006500B2

公开(公告)日：2024-06-11

申请号：US17157920

申请日：2021-01-25

申请人： Sirnaomics, Inc.

发明人： Danny Tang ,  Xueping Chen ,  Patrick Y. Lu ,  Vera Simonenko ,  David Evans ,  John Xu ,  Deling Wang ,  Alan Lu

IPC分类号： C12N15/113 ,  A61K9/51 ,  A61K31/713 ,  A61K47/28 ,  A61K47/69 ,  A61P31/14

CPC分类号： C12N15/113 ,  A61K9/513 ,  A61K31/713 ,  A61K47/28 ,  A61K47/6931 ,  A61P31/14

摘要： Compositions and methods for development of potent siRNA therapeutics for prevention and treatment of Corona Virus (2019-nCoV; COVID-19) infections are provided. The compositions include a pharmaceutical composition comprising siRNA cocktails that target critical viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Administration methods for prevention and treatment are provided, including airway instillation, subcutaneous injections and nebulizer aerosolization.

公开(公告)号：US11058779B2

公开(公告)日：2021-07-13

申请号：US15758312

申请日：2016-09-07

申请人： Sirnaomics, Inc.

发明人： Patrick Y. Lu ,  Vera Simonenko ,  Yibin Cai ,  John Xu ,  David Evans

IPC分类号： A61K48/00 ,  C12N15/11 ,  C07H21/02 ,  C07H21/04 ,  A61K9/51 ,  A61K9/127 ,  A61K47/54 ,  A61P31/14 ,  A61K47/28 ,  C12N15/113 ,  C12N15/88 ,  B82Y5/00

摘要： The present invention relates to compositions and methods for siRNA therapeutics for prevention and treatment of Middle East Respiratory Syndrome Corona Virus (MERS-CoV) infections. The compositions include a pharmaceutical composition comprising siRNA cocktails that target viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers.

公开(公告)号：US11697813B2

公开(公告)日：2023-07-11

申请号：US16343309

申请日：2017-10-30

申请人： Sirnaomics, Inc. ,  Jia Zhou ,  Qingfeng Li

发明人： John Xu ,  Patrick Y. Lu ,  Jia Zhou ,  Qingfeng Li ,  Vera Simonenko

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  A61K31/713 ,  A61K47/34

CPC分类号： C12N15/1136 ,  A61K31/713 ,  A61K47/34 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/30

摘要： The current invention provides a method of activating fibroblast and myofibroblast apoptosis in a tissue of a mammal, comprising administering to the tissue a therapeutically effective amount of a composition comprising an siRNA molecule that binds to an mRNA that codes for TGFB1 protein in a mammalian cell, an siRNA molecule that binds to an mRNA that codes for COX-2 protein in a mammalian cell, and a pharmaceutically acceptable carrier comprising a pharmaceutically acceptable histidine-lysine polymer. The invention also provides additional methods for using this composition.

公开(公告)号：US09868952B2

公开(公告)日：2018-01-16

申请号：US14418432

申请日：2013-07-07

申请人： Sirnaomics, Inc.

发明人： Patrick Y. Lu ,  David M. Evans ,  John J. Xu ,  Alan Y. Lu ,  Qing Ge

IPC分类号： C12N15/11 ,  C12N15/113 ,  A61K9/00 ,  A61K31/713

CPC分类号： C12N15/1131 ,  A61K9/007 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/11 ,  C12N2320/31 ,  C12N2320/32

摘要： The present invention relates to compositions and methods for development of resistance-proof siRNA therapeutics for prevention and treatment of influenza viral infections. The compositions include a pharmaceutical composition comprising siRNA molecules that target conserved regions of an influenza virus gene and a pharmaceutically acceptable polymeric carrier. In one embodiment, the polymeric carrier condenses the molecules to form a nanoparticle.

公开(公告)号：US20170233742A1

公开(公告)日：2017-08-17

申请号：US15518706

申请日：2015-10-16

申请人： Sirnaomics, Inc.

发明人： Yibin Cai ,  Patrick Y. Lu ,  John J. Xu

IPC分类号： C12N15/113 ,  C12Q1/70 ,  A61K49/00

CPC分类号： C12N15/1131 ,  A61K31/713 ,  A61K47/62 ,  A61K47/6929 ,  A61K49/0008 ,  C12N2310/14 ,  C12N2320/31 ,  C12Q1/18 ,  C12Q1/701 ,  C12Q2600/136 ,  C12Q2600/178

摘要： Disclosed herein are small interfering RNA (siRNA) molecules and pharmaceutical compositions containing them for the prevention and treatment of Ebola virus disease. The present invention provides siRNA molecules that inhibit Ebola virus gene expression, compositions containing the molecules, and methods of using the molecules and compositions to prevent or treat EVD in a subject, such as a human patient.

公开(公告)号：US20160068843A1

公开(公告)日：2016-03-10

申请号：US14418432

申请日：2013-07-07

申请人： Sirnaomics, Inc.

发明人： Patrick Y. Lu ,  David M. Evans ,  John J. Xu ,  Alan Y. Lu ,  Qing Ge

IPC分类号： C12N15/113 ,  A61K9/00 ,  A61K31/713

CPC分类号： C12N15/1131 ,  A61K9/007 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/11 ,  C12N2320/31 ,  C12N2320/32

摘要： The present invention relates to compositions and methods for development of resistance-proof siRNA therapeutics for prevention and treatment of influenza viral infections. The compositions include a pharmaceutical composition comprising siRNA molecules that target conserved regions of an influenza virus gene and a pharmaceutically acceptable polymeric carrier. In one embodiment, the polymeric carrier condenses the molecules to form a nanoparticle.

摘要翻译： 本发明涉及用于开发用于预防和治疗流感病毒感染的耐药性siRNA治疗剂的组合物和方法。 组合物包括药物组合物，其包含靶向流感病毒基因的保守区域的siRNA分子和药学上可接受的聚合物载体。 在一个实施方案中，聚合物载体冷凝分子以形成纳米颗粒。

公开(公告)号：USRE46873E1

公开(公告)日：2018-05-29

申请号：US15166223

申请日：2016-05-26

申请人： Sirnaomics, Inc.

发明人： Patrick Y. Lu ,  Ling Li ,  Vera Simonenko

IPC分类号： C07H21/04 ,  A61K48/00 ,  A61K31/7105 ,  C12N15/113

CPC分类号： A61K31/7105 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14

摘要： The present invention provides small interfering RNA (siRNA) molecules, compositions containing them, and methods of using them for improvement of skin scarless wound healing and other skin conditions, such as psoriasis and lupus-caused cutaneous lesions. The invention includes siRNA molecules and compositions containing them that inhibit the expression of one or more genes that promote pathological or undesired processes in wound healing and methods of using them.