- 专利标题： Composition and methods of RNAi prophylactics and therapeutics for treatment of severe acute respiratory infection caused by 2019 novel coronavirus (2019-nCoV)
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申请号： US17157920申请日： 2021-01-25
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公开(公告)号： US12006500B2公开(公告)日： 2024-06-11
- 发明人: Danny Tang , Xueping Chen , Patrick Y. Lu , Vera Simonenko , David Evans , John Xu , Deling Wang , Alan Lu
- 申请人： Sirnaomics, Inc.
- 申请人地址： US MD Gaithersburg
- 专利权人： Sirnaomics, Inc.
- 当前专利权人： Sirnaomics, Inc.
- 当前专利权人地址： US MD Germantown
- 代理机构： Edell, Shapiro & Finnan, LLC
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K9/51 ; A61K31/713 ; A61K47/28 ; A61K47/69 ; A61P31/14
摘要：
Compositions and methods for development of potent siRNA therapeutics for prevention and treatment of Corona Virus (2019-nCoV; COVID-19) infections are provided. The compositions include a pharmaceutical composition comprising siRNA cocktails that target critical viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Administration methods for prevention and treatment are provided, including airway instillation, subcutaneous injections and nebulizer aerosolization.
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